Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Are we being too harsh on quantitative #metrics for researcher assessment?

John Ioannidis & Zacharias Maniadis argue for using rigorous, field-adjusted, centralized, quantitative metrics to help improve research practices as a low-cost public good.

https://plos.io/4167hTa

My brother just got hit by a really insidious bank scam. Scammers spoofed caller ID with citibank’s real online banking number and tell him “there was a fraudulent Zelle transfer from your account. Call Zelle at this number.” Fake-Zelle rep confirms fake case numbers that fake-Citi gave him, dazzles with still more bullshit and gets him to actually transfer money to them under some plausible sounding “fix” pretext. Slick. Citi says it’s a new one on them and are investigating ASAP.

Alexandre Dumas père, one of the most prolific and most popular French authors of the 19th century died #OTD in 1870. Close to the Romantics and turned towards the theater, he first wrote a successful vaudeville and historical dramas. A prolific writer, he then turned to historical novels such as the Musketeers trilogy, or Le Comte de Monte-Cristo, La Reine Margot and La Dame de Monsoreau. The authorship of some of his works is disputed.

Alexandre Dumas at PG:
https://www.gutenberg.org/ebooks/author/492

#books

#RiboSeq suggests pervasive translation of noncanonical short ORFs, but shotgun MS detects very few - why? @aaronwacholder & @carvunis explore this, showing that shotgun MS has intrinsically low sensitivity for small, low-abundance proteins #PLOSBiology https://plos.io/3t8CfgI

From @RELenski post, How to Write a Response to Reviewers in Ten Easy Steps:

"Pay special attention to comments where two (or more) reviewers comment on the same issue. If they both agree (for example, they tell you to clarify or delete some passage), then that is almost certainly something you should do"

https://telliamedrevisited.wordpress.com/2020/07/15/how-to-write-a-response-to-reviewers-in-ten-easy-steps/

"Double Villain”, Prato falante.
Glazed #stoneware by @hunchbacksociety

#proverbs #proverbios #ceramics #plate #pottery #artgallery #artstagram #handmade #ceramic

https://hunchbacksociety.cargo.site

This year I finished one of the most fascinating projects I ever worked on.

Together with a team of researchers from the molecular neurodegeneration department at Amsterdam UMC we came up with a visual and interactive way to present their latest paper on tau protein aggregation and its effect on astrocytes.

🧵
#neuroscience #dementia #alzheimers #science #scicomm #design #UI #gamedev #ScienceMastodon #visualStorytelling #astrocytes

An Ancient Art Form Topples Assumptions about Mathematics | Scientific American
https://www.scientificamerican.com/article/an-ancient-art-form-topples-assumptions-about-mathematics/

Distance-AF: Modifying Predicted Protein Structure Models by Alphafold2 with User-Specified Distance Constraints https://www.biorxiv.org/content/10.1101/2023.12.01.569498v1.full.pdf+html

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#proteomics #prot-preprint

This one has it all: mystery western blot bands, red blood cells, pandemic disruptions, grumpy reviewers 🎧👇

#SciComm #SciencePodcast #EMBOPodcast

https://www.embo.org/podcasts/the-band-and-the-rhythm/

"Here, we summarize the latest insights into cellular uptake mechanisms and pathways in DCs. We highlight the approaches to study endocytosis, the impact of endocytosis routes on T cell response, and discuss the link between how DCs internalize therapeutic antibodies and the potential mechanisms that could give rise to immunogenicity"

https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250340

"We hypothesized that elevated Gαq stimulation within the syncytiotrophoblast layer contributes to the pathogenesis of #preeclampsia through disruption of normal redox balance and thus the induction of syncytiotrophoblast stress."

https://www.science.org/doi/10.1126/sciadv.adg8118

"The book wasn’t published for two years, not before perestroika and Gorbachev. “After reading your book no one will fight,” the censor lectured me. “Your war is terrifying. Why don’t you have any heroes?” I wasn’t looking for heroes. I was writing history through the stories of its unnoticed witnesses and participants. They had never been asked anything."
- Svetlana Alexievich

https://www.nobelprize.org/prizes/literature/2015/alexievich/lecture/?ref=thebrowser.com

Buster Keaton's "The General" at one of Lisbon's most special spots, a Cinemateca Portuguesa. Bonus: accompanied by a live pianist.

http://www.cinemateca.pt/Entrada.aspx

AlphaFold & PDL1

"Here, we test a protein design pipeline that uses iterative rounds of deep learning (DL)-based structure prediction (AlphaFold2) and sequence optimization (ProteinMPNN) to design autoinhibitory domains (AiDs) for a PD-L1 antagonist."
#Immunology #CheckpointInhibitor

https://www.pnas.org/doi/10.1073/pnas.2307371120