"Here, we combine a stationary-phase screening method with deep learning-powered virtual screens and toxicity filtering to discover compounds with lethality against metabolically dormant bacteria and favorable toxicity profiles."
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00387-2
Nadine Randel and I wrote a dispatch on the recent miniature-wasp eye #connectome paper
Have a look:
https://www.sciencedirect.com/science/article/pii/S096098222301432X?dgcid=author
and here is the original paper on the Megaphragma eye by Chua and colleagues https://www.sciencedirect.com/science/article/pii/S096098222301237X
Interesting! L-fucose administration ameliorates the LPS-induced neuroinflammation in the Fut8+/− mice, suggesting that core fucosylation plays a vital role in anti-inflammation. L-Fuc as a potential drug against neuroinflammation?
"I wanted other people to know that if you fail the first time, it's not the end of the story."
https://nitter.cz/MaricutAkbik
won an ERC grant on her 2nd attempt. She explains her application strategy, plus use of ERC feedback. 👉
https://europa.eu/!Jhrk6D
https://nitter.cz/PolSciLeiden
https://nitter.cz/UniLeidenNews
https://nitter.cz/UniLeiden
🐦🔗: https://nitter.cz/ERC_Research/status/1732006990900281701#m
[2023-12-05 12:00 UTC]
rs - a multigenerational, ultra-wealthy drug-pusher dynasty - made billions while murdering hundreds of thousands of Americans by lying about the safety of #Oxycontin, the flagship product of their #PurduePharma drug company. *It's that they got away with it*.
--
If you'd like an essay-formatted version of this thread to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:
https://pluralistic.net/2023/12/05/third-party-nonconsensual-releases/#au-recherche-du-pedos-perdue
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"Sellafield, Europe’s most hazardous nuclear site, has a worsening leak from a huge silo of radioactive waste that could pose a risk to the public, the Guardian can reveal."
“El caso es que esos hematófagos se extinguieron, y no sabemos por qué. Tal vez hubo más recursos para la hematofagia durante el cretácico temprano y luego los recursos disminuyeron o la competencia entre moscas hematófagas llevó a la extinción de los taxones menos adaptados”
This is easily my favorite preprint title of the past couple of months: "Artificial bees collect diverse conformers of small organic molecules"
https://arxiv.org/pdf/2311.18600.pdf
"The European Commission’s statements indicate education, research and innovation talks will progress in parallel to the future wider Swiss-EU negotiations. They follow a declaration on November 8 by the Swiss government that it would decide its overall negotiating position by the end of the year for the next stage of talks to regulate its long-term relationship with the EU."
"Ainda em setembro, quando foi confirmada a presença dos mosquitos Aedes Albopictus na região de Lisboa, a Direção-Geral da Saúde (DGS) criou uma taskforce para monitorizar a evolução do inseto, juntando vários especialistas e reforçando a vigilância destas espécies em todo o país."
"Detailed media reports show them hounding poor patients for money, cutting nurse staffing too aggressively and giving preferential treatment to the rich over the poor. Nurses and other workers recently resorted to strikes to improve workplace safety at Kaiser Permanente and the Robert Wood Johnson University Hospital in New Brunswick, N.J."
https://www.nytimes.com/2023/11/30/opinion/hospitals-nonprofit-community.html
'Elliot Erwitt con su imagen de perros más famosa, en una exhibición el 29 de noviembre de 1994.
STEVEN SIEWERT (GETTY IMAGES)' https://elpais.com/cultura/2023-12-01/muere-elliot-erwitt-el-fotografo-de-los-ninos-y-los-perros.html
Protip:
"I include two guest lectures from my university’s librarians: one on literature searching and reference management, and one on “deep reading”. University librarians are, in my experience, eager to help with teaching; I strongly recommend involving them in a writing course (or, for that matter, in any other course)."
"O coordenador do programa do PSD para as eleições legislativas de 2011, Eduardo Catroga, escreveu uma carta a Ricardo Salgado, depois de os sociais-democratas terem conquistado o poder e cujo conteúdo sugere o envolvimento do então presidente do Banco Espírito Santo (BES) na elaboração das medidas propostas pelo partido para sanear o sector bancário, numa época em que o seu império já vivia grandes dificuldades, mas quando elas ainda não eram do conhecimento público"
'Pese al criterio de los expertos en Estados Unidos, la legislación antitrans avanza imparable. Hay un gráfico elocuente que compara el mapa del país el 1 de enero de 2021 con el de este otoño. En el de la izquierda, los 50 Estados aparecen en blanco. En el de la derecha, lucen coloreados los 22 que han aprobado leyes que prohíben a los menores el acceso a los tratamientos de género.'
December. For many years this time of the year meant rush, pressure and huge stress to me. I had to think over a lot and change a lot to enjoy this time again. First, I stopped buying - new ornaments and many unnecessary things. Avoiding shops and crowds in December is the best thing I could do for myself. And if I want some new Xmas ornaments I use old baubles and paint them with acrylic paint or make paper ornaments.
#RepairReuseRecycle #diy #MonochromePhotography #MonochromeMonday
'Novo Nordisk chief executive Lars Fruergaard Jørgensen has set his eyes on another “gold mine”: trial data that could offer clues on why some people are more likely to gain weight, and perhaps even lead to the first drugs designed to prevent obesity.'
https://www.ft.com/content/63092b84-1ec6-42cf-85ba-f4578f31d3ab
For the Robert Mitchum or Radio Raheem fan in your life. Prato falante/Glazed #stoneware by @hunchbacksociety
#proverbs #proverbios #ceramics #plate #pottery #artgallery #handmade #artmastodon #ceramic
@madparreira.bsky.social
https://madalenaparreira.com/Hunchbacksociety
Globally, #obesity is on the rise.
Ann Marie Schmidt looks at how research over the past 20 years has changed the way we view obesity and what the future might hold.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com