Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'The Russian government’s invasion cut off pharmaceutical supplies (...) More than 100,000 Ukrainians with H.I.V., for example, were threatened with losing access to the lifesaving antiretroviral medications they needed.'
https://www.nytimes.com/2023/12/25/opinion/global-immune-system-public-health.html
Thiago Carvalho
boosted
"Tumor interstitial fluid nutrient composition closely resembles kidney interstitial fluid, suggesting that tissue-specific factors unrelated to the presence of cancer exert a stronger influence on nutrient levels than tumor-driven alterations"
#Metabolism
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Exciting venture ahead as Michael Bader and colleagues at #mdcBerlin and Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) found Trypto Therapeutics to bring their serotonin-regulating agent, TPT-004, to market! Join the journey of innovation! #StartUp
Read more:
https://www.mdc-berlin.de/news/press/new-agent-regulates-serotonin-production
Thiago Carvalho
boosted
"Younger people—typically at low risk—are especially vulnerable to COVID-related heart attacks, with the sharpest relative rise in deaths occurring in people ages 25 to 44, research by Los Angeles’ Cedars-Sinai Medical Center shows." https://www.prevention.com/health/health-conditions/a46131357/heart-problems-after-covid/
Thiago Carvalho
boosted
"Here, by studying 98 tissues from 27 deceased transplant organ donors we demonstrate that despite representing less than 5% of circulating Tregs, fully functional, thymically derived CD8+FOXP3+ Tregs are highly enriched in human tissues particularly in non-lymphoid tissues and bone marrow, where they reside as CD25lo/-CD8+CD69+CD103+TLR9+HELIOS+FOXP3+ Tregs."
#Preprint #Immunology
Thiago Carvalho
boosted
'Candice Breitz, Deborah Feldman and Masha Gessen are just the latest to be ‘lectured’, as Eyal Weizman put it, ‘by the children and grandchildren of the perpetrators who murdered our families and who now dare to tell us that we are antisemitic’.'
https://www.lrb.co.uk/the-paper/v46/n01/pankaj-mishra/memory-failure
Thiago Carvalho
boosted
'The book that gives us Calvino the romantic and Calvino the craftsman in equal measure is “If on a Winter’s Night a Traveler.” It is the book that makes people fall in love with Calvino, because it is a book about falling in love through reading—specifically, “reading Italo Calvino’s new novel, If on a winter’s night a traveler.”' (Illustration by Daniele Castellano)
https://www.newyorker.com/magazine/2023/03/06/the-worlds-of-italo-calvino
"O racismo e a ausência de sentido crítico em relação ao colonialismo, em Portugal, vêm de longe. Não vale a pena negar que é assim. A inferiorização de pessoas e uma descrição idealizada do processo dos Descobrimentos fizeram parte dos manuais escolares da grande maioria dos portugueses."
https://www.publico.pt/2023/12/27/opiniao/opiniao/ventura-traficante-louro-prensado-2074907
Thiago Carvalho
boosted
Nature is going into full Buzzfeed mode with its headlines
Just waiting until that happens to research paper titles as well…
Thiago Carvalho
boosted
Happy 200th Birthday to French chemist and microbiologist Louis Pasteur!
He is renowned for his discoveries of the principles of vaccination, microbial fermentation, and pasteurization, the last of which was named after him. His research in chemistry led to remarkable breakthroughs in the understanding of the causes & preventions of diseases, which laid down the foundations of hygiene, public health & much of modern medicine.
Louis Pasteur at PG:
https://www.gutenberg.org/ebooks/search/?query=louis+pasteur&submit_search=Go%21
I havent bought holiday greeting cards in a very long time. But if I saw this one, I'd get a box.
"The rate of serious medical complications increased in hospitals after they were purchased by private equity investment firms, according to a major study of the effects of such acquisitions on patient care in recent years."
https://www.nytimes.com/2023/12/26/upshot/hospitals-medical-errors.html
'In Novo Nordisk’s case, thanks to the success of GLP-1s, its owner is now bigger than the Bill & Melinda Gates Foundation or the Wellcome Trust, the two other powerhouses of medical research funding and philanthropy.'
https://www.ft.com/content/69324884-a626-4787-a4ce-aece410d1dcc
"Tumor interstitial fluid nutrient composition closely resembles kidney interstitial fluid, suggesting that tissue-specific factors unrelated to the presence of cancer exert a stronger influence on nutrient levels than tumor-driven alterations"
#Metabolism
Thiago Carvalho
boosted
Christmas is coming early this year: we just dropped a new preprint!
"Beyond networks: explaining dynamics in the natural and social sciences."
It's a broad criticism of network modeling in both the natural & social sciences & a study of where its shortcomings originate historically. 🧵
Thiago Carvalho
boosted
"However, the metrics generally used to evaluate protein structure prediction methods—including all of those used in CASP—focus on the overall accuracy of predicted structures, rather than on their utility in predicting ligand binding. This has left the large community of academic and industrial researchers who wish to use protein structures to design drugs and other ligands unsure of whether, when, and how to use the new structural models. Improvements in protein structure prediction are widely assumed to lead to better models of ligand-binding pockets and thus more accurate predictions of ligand binding (Beuming and Sherman, 2012; Bordogna et al., 2011; Erickson et al., 2004), but to what extent do these assumptions hold?"
Thiago Carvalho
boosted
The AMA says that repeated Covid infections greatly increase the risk of serious disease.
Thiago Carvalho
boosted
Today we celebrate the birth of Sir Isaac Newton. Without his invention of calculus we would have no way to stop people who are bad at math from becoming engineers.
'The book that gives us Calvino the romantic and Calvino the craftsman in equal measure is “If on a Winter’s Night a Traveler.” It is the book that makes people fall in love with Calvino, because it is a book about falling in love through reading—specifically, “reading Italo Calvino’s new novel, If on a winter’s night a traveler.”' (Illustration by Daniele Castellano)
https://www.newyorker.com/magazine/2023/03/06/the-worlds-of-italo-calvino
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
