Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"In memory T cells, the frequency of CXCR5+CXCR3+CCR6− circulating follicular Th1 was positively correlated with RBD-specific Ab-secreting B cells. For the response to variant RBDs, although 60–80% of memory B cells could bind to the omicron RBD, their avidity was low, whereas memory T cells show an equal response to the omicron spike."
"The human MPYS gene is highly heterogeneous (9, 10). Approximately 50% of Americans carry a non–wild-type (WT) (R232) MPYS allele (9). R71H-G230A-R293Q (HAQ) is the second most common human MPYS allele carried by ∼25% of Americans and ∼63% of East Asians (EAS) (9). Surprisingly, we recently found that HAQ knock-in mice do not respond to CDNs in vivo (11). In corroboration, Mogensen and colleagues (12) reported that homozygous HAQ MPYS/STING was enriched in HIV-infected individuals that were long-term nonprogressors."
Thiago Carvalho
boosted
Hi #introduction from me..!
I'm a Prof of Operational Research at UCL & member of Independent SAGE.
As such, I've been tweeting about Covid for 2.5 yrs now so expect more of that here!
Plus occasional forays into politics, women in science, general science & stuff about London.
Hope I get the hang of it soon!
Thiago Carvalho
boosted
‘Eat local’ is a common recommendation to reduce the carbon footprint of your diet.
But transportation makes up a very small amount of the greenhouse gas emissions from food.
*What* you eat is far more important than *where* your food traveled from.
Thiago Carvalho
boosted
The distribution map of the hoverfly Eristalis pertinax may be telling a story about failed clean water regulations:
“Eristalis pertinax is a European hoverfly. Like Eristalis tenax, the larva of E. pertinax is a rat-tailed maggot and lives in drainage ditches, pools around manure piles, sewage, and similar places containing water badly polluted with organic matter.” https://www.inaturalist.org/taxa/52490?locale=en-GB
Caveats: sampling bias, and unknown distribution prior to modern waterways pollution.
Thiago Carvalho
boosted
Scientists! Many of my fellow reporters at @sciencemagazine are here now:
Ace pandemic reporters @kakape and @joncohen;
@rpocisv, covering diversity in science;
@boron110, our delightful podcast host;
@martinenserink, international editor and public health guru;
@klangin, covering the scientific workforce;
@DanClery, covering astronomy;
@lguterman, editing chem and bio;
@cathleenogrady, writing about science and society;
@meredithwadman@newsie.social, covering medicine and bad behavior.
Thiago Carvalho
boosted
Hi #ScienceMastodon. We, at #Dev_journal, are a #community journal covering #DevBio, #stemcells, #regeneration and more. Development is led by Editor-in-Chief @jamesbriscoe & published by the not-for-profit @Co_Biologists.
We’ll be tooting about our #research papers, #reviews, #interviews, charitable activities, #conferences and #devbiol news from our community site, @the_node.
Toots by Online Editor @helenzsci, Reviews Editor @amjeve & Executive Editor Katherine Brown
Thiago Carvalho
boosted
#introduction. I am a plant developmental geneticist. The lab addresses a fundamental biological question: how does morphogenesis translate genotype into form? To this end we study signaling at the plasma membrane - cell wall interface and we investigate how mechanical forces influence tissue shape using 3D digital ovules.
Main interests:
#Arabidopsis #cellbiology #cellbio #cellwall #devbio #devbiol #DevelopmentalBiology #evodevo #imaging #mechanobiology #microscopy #plantbiology
Thiago Carvalho
boosted
Time for my #neuroscience #introduction here. I am studying the nervous systems of jellyfish using computational modelling, trying to understand their dynamics and their evolution. I use biophysical neuron models and feed the resulting dynamics of their network into fluid dynamics simulations to study how their neuronal dynamics control the swimming and turning of these strange creatures.
'Drug resistance is a known risk factor for poor tuberculosis (TB) treatment outcomes, but the contribution of other bacterial factors to poor outcomes in drug susceptible TB is less understood. Here, we generate a population-based dataset of drug-susceptible Mycobacterium tuberculosis (MTB) isolates from China to identify factors associated with poor treatment outcomes.'
https://www.biorxiv.org/content/10.1101/2022.11.20.517261v1?med=mas
'Verified accounts are frequently seen as reliable and trustworthy, and Twitter’s algorithm gives them a higher ranking in search results, replies and follow recommendations.
“There’s a sense of legitimacy that comes with it,” said Barry. “By verifying this anti-vaccine account, they’re kind of verifying all of the misinformation it shares … it makes people think, ‘Oh, well, this is a verified account. This must be true.’”
" Management of the SVD outbreak in Uganda in 2000 was complicated by the fact that the outbreak-response team did not understand the local health beliefs and missed an opportunity to align their risk communication with the population’s understanding of disease transmission.5 This hard-won lesson has led to the regular inclusion of anthropologists in response teams to aid in designing and implementing control measures."
#Virology #Epidemiology #Filovirus #NEJM
https://www.nejm.org/doi/full/10.1056/NEJMp2213975?query=featured_home
Thiago Carvalho
boosted
Fighting health misinformation on social media has been hard enough these last ~3 years, but will be almost impossible now that "[Twitter's] paid verification system is being used to give sense of validity to accounts pushing health misinformation."
An important read from @m_scribe at https://www.theguardian.com/technology/2022/nov/21/twitter-anti-vax-health-misinformation?CMP=Share_iOSApp_Other
Thiago Carvalho
boosted
Or maybe you could just pay them properly?
RT @Smyth_Chris@twitter.com
Sunak repeatedly says the NHS must be more innovative and "radically" change how it cares for patients
"We need to be bold and radical in challenging conventional wisdom," he says. Examples include "thinking creatively" about what doctors, nurses and other staff actually do
🐦🔗: https://twitter.com/Smyth_Chris/status/1594645666847940609
Thiago Carvalho
boosted
Postdoctoral position - Drosophila - neurodegeneration
Come join us in #NYC as a #drosophila postdoc, with a focus on #neurodegeneration.
https://jobrxiv.org/job/new-york-university-grossman-school-of-medicine-27778-postdoctoral-position-drosophila-neurodegeneration/?feed_id=29876
#ScienceJobs #ScienceJobs
New York, #UnitedStatesUS #PostdoctoralFellow
https://jobrxiv.org/job/new-york-university-grossman-school-of-medicine-27778-postdoctoral-position-drosophila-neurodegeneration/?feed_id=29876
Thiago Carvalho
boosted
If anyone fancies watching a beautiful 6 minute scientific video about #SARSCoV2 life cycle, this is really quite absorbing... #COVID19 #IDMastodon #virology
https://youtu.be/k2GlafQ9YhY
Thiago Carvalho
boosted
What determines our organs' architecture? How can we measure, predict, and manipulate it? Scientists around Keisuke Ishihara @IshiharaKsk from the lab of Elly Tanaka (@tanaxolotl) have tackled the question using neuroepithelial #organoids. (1/4)
https://www.nature.com/articles/s41567-022-01822-6
Thiago Carvalho
boosted
Enterovirus D68 (EV-D68) is clearly associated with the childhood paralysis disease Acute Flaccid Myelitis. However, the upsurge in EV-D68 infections this year has not resulted in more paralytic disease, and we do not know why. Hear a clinical perspective here: https://www.youtube.com/playlist?list=PLV5owftAGKzaJXz3_x4sOv0UrcdPweuD_
#AFM acuteflaccidmyelitis.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
