Thiago Carvalho @cyrilpedia@social.cleverlibre.org

@gregggonsalves John Huston made a film version with his daughter Angelica in the 80s - I remember it is a being very good (but have not watched in decades)

"Older vaccines use the postfusion, or Post-F, version of the protein, whereas new vaccines employ a prefusion stabilized, or Pre-F, immunogen. Here, Chang and Phung et al. directly compared immune responses elicited by a Post-F vaccine, MEDI7510, and a Pre-F vaccine, DS-Cav1. The authors found that DS-Cav1 elicited antibodies that more potently neutralized RSV A and B than MEDI7510. This enhanced response was mediated by the presence of antibodies that could bind sites on the F protein that were only present in the Pre-F state."

#RSV #RespiratorySyncytialVirus #Immunology #Vaccine

https://www.science.org/doi/abs/10.1126/scitranslmed.ade0424

The Nation's 1955 article on the Emmett Till "trial":

'Citizens who drink from the “Whites Only” fountain in the courthouse breathe much easier now that the two fair-skinned half brothers, ages twenty-four and thirty-six, have been acquitted of the murder of a fourteen-year-old Negro boy. The streets are quiet, Chicago is once more a mythical name, and everyone here “knows his place.”

https://www.thenation.com/article/archive/land-of-the-free-this-firsthand-report-from-the-emmett-till-murder-trial-is-chilling-to-read-today/?ref=the-browser

"When Fauci was born in Brooklyn, New York, on Christmas Eve in 1940, Franklin Roosevelt had just been re-elected for a third term in the White House and Adolf Hitler was on the march in Europe. Fauci captained his school basketball team but was too short in stature to make a career of it. He studied humanities, philosophy, Greek and Latin and just enough science to get into medical school."

https://www.theguardian.com/us-news/2022/dec/25/fauci-interview-covid-trump-biden

Tools

"Here we incorporated inside EVs the endogenous retrovirus-like Arc protein capsids, stabilized by Arc 5'UTR RNA elements, to effectively load and deliver mRNAs. Produced from self-derived leukocytes, engineered retrotransposon Arc EVs (eraEVs) are immunologically inert with minimal clearance. Equipped with endothelial adhesion molecules from donor leukocytes, circulating eraEVs enter the brain enriching at neuro-inflammatory sites. "

#Preprint #Neuroscience #BloodBrainBarrier

https://www.biorxiv.org/content/10.1101/2022.12.07.518870v2

Holiday cheer from @adamtooze

"In this politicised tripolar world economy — formed by the US, EU and China — the basic source of tension is the confrontation between Washington and Beijing. On top of Russia’s attack on Ukraine, escalating tension over Taiwan made 2022 the year in which a third world war became a real tail risk."

https://www.ft.com/content/c609f8c6-9484-4c1f-945d-5dc5b208e615

"David Lynch as John Ford."
'nuff said

https://www.youtube.com/watch?v=POgWODZyUGQ

The Bear gets my vote for best new show of the year:

"The story of Carmy Berzatto, a celebrated chef who returns home to save the family business after the suicide of his brother, The Bear arrives at a gallop and never lets up. There’s obsession. There’s chaos. There is an episode delivered in a single breathless shot."

(Most disappointing was seeing the Jeff Bridges & John Lithgow stuck with writing worthy of a straight-to-video Putin-produced Steven Seagal film).

https://www.theguardian.com/tv-and-radio/2022/dec/25/the-bear-jeremy-allen-white-best-workplace-drama-since-mad-men

'In recent years, the vast archaeological park of Pompeii, a city buried alive by the eruption of Vesuvius in A.D. 79, has turned to high-tech options to maintain its excavated ruins. A surveillance drone makes a monthly flight over the site’s roughly 10,000 exhumed rooms. Artificial intelligence programs analyze aerial images for new cracks, fallen stones and other signs of erosion. But to prevent the third of the park that remains hidden under pumice and meters of earth from becoming overgrown with thorn bushes, wild hedges and trees, Pompeii has found a more appropriately ancient, and inexpensive, solution in hungry sheep.'

https://www.nytimes.com/2022/12/22/world/europe/pompeii-sheep-mount-vesuvius.html