@Homo_viator Maybe missing the picture?
"This observation raises a question of fundamental importance: if natural mucosal respiratory virus infections do not elicit complete and long-term protective immunity against reinfection, how can we expect vaccines, especially systemically administered non-replicating vaccines, to do so? This is a major challenge for future vaccine development, and overcoming it is critical as we work to develop “next-generation” vaccines."
Perspective @cellhostmicrobe by David Morens, Jeffery Taubenberger & Anthony Fauci
#Vaccines #PublicHealth #Vaccine Development #Virus #Virology #Immunology #Coronavirus #Covid #Covid19 #Influenza #RespiratoryVirus #MucosalImmunology
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00572-8
"We found that TCR signal intensity coupled STING signal strength to the unfolded protein response (UPR) and T cell survival. Under strong STING signaling, Indoleamine-pyrrole 2,3-dioxygenase (IDO) inhibition also reduced apoptosis and led to a recovery of T cell memory in STING sufficient CD8 T cells."
RT @GeoffreySupran@twitter.com
NEW: In @ScienceMagazine@twitter.com today, our latest peer-reviewed research shows Exxon scientists predicted global warming with shocking skill & accuracy between 1977 & 2003, contradicting the company's decades of climate denial. THREAD.
📰No pay wall for 2 weeks: http://bit.ly/ExxonKnew2point0
🐦🔗: https://twitter.com/GeoffreySupran/status/1613611667254046721
“Menstruation and the week before menstruation have been identified by patients as triggers for relapses of long COVID symptoms.”
❤️
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RT @LulaOficial
Hoje agradeci os trabalhadores que limparam e reergueram o Palácio do Planalto em pouquíssimos dias, depois do estrago feito por vândalos. Esse é um patrimônio do povo brasileiro, de todos nós. Muito obrigado.
📸: @ricardostuckert
https://twitter.com/LulaOficial/status/1613998712669278219
Immunity to the microbiota promotes sensory neuron regeneration
Here’s some cleared postnatal cerebellum #microscopy #EyeCandy to continue my #neuroscience #introduction. This image volume was acquired by Niraj Trivedi in my lab on an UltraMicroscope II. Magenta is the nucleus of all proliferating cerebellar granule #neurons in the external granule layer 🤩 These cells proliferate faster than a tissue culture cell line in a dish 🤯
Small Bird on a Branch of Kaidozakura, 1848 #ukiyoe #utagawahiroshige https://www.wikiart.org/en/hiroshige/small-bird-on-a-branch-of-kaidozakura-1848
Please feel free to reach out to me with any questions about the role, the journal or the team (also to eg @RoliRoberts if questions are about me 😉)
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RT @npariente
Are you an #editor with expertise in #neuroscience? Come join our team!
This might be the right next step for you -we are looking for our next Neurobiology Section Manager, key position in the @PLOSBiology team
To apply (considered upon receipt) https://plos.io/3kh5ARD
#ca…
https://twitter.com/npariente/status/1613957132373590039
California Attorney General Sues Drugmakers Over Inflated Insulin Prices https://khn.org/MTYwNjY3MQ via @khnews
Epidemiologist Celine Gounder, wife of late sports journalist #GrantWahl, on the nightmare of #anti-vaxx ghouls using her husband's death to promote their lies. #COVID19 #publichealth #medicine https://www.pbs.org/newshour/show/grant-wahls-wife-fights-vaccine-misinformation-in-the-wake-of-her-husbands-death
The narrow alleys of Japan have a coexistence world of humans and cats. #followfriday #streetphotography #photography
Lots of questions about if future SARS-CoV-2 variants might be more or less severe.
I don’t have a crystal ball.
But in this thread, I’ll describe what happened w other rapidly evolving respiratory viruses after initial pandemic, & describe some relevant SARS-CoV-2 data.
Plot below shows mortality due to influenza virus in USA during and after 1918 H1N1 & 1968 H3N2 influenza pandemics.
Interactive version of plot is at https://jbloomlab.github.io/flu_mortality/ and data are taken from https://academic.oup.com/jid/article/178/1/53/919896
"However, binding and neutralization have poorly predicted protection in the past, and accumulating data across epidemiologic cohorts and animal models collectively point to a role for additional antibody Fc-effector functions. To begin to define the humoral correlates of immunity against RSV, here we profiled an adenovirus 26 RSV-preF vaccine-induced humoral immune response in a group of healthy adults that were ultimately challenged with RSV."
'The threat of this outbreak almost restarted efforts to test a new vaccine for the strain of Ebola that generated these infections. The work had previously been abandoned due to lack of financing, profit, and political will. The outbreak ignited a spark of hope, but it looks to have subsided before the vaccine trials could be implemented.'
"We have discovered the Caenorhabditis elegans homeodomain-interacting protein kinase (HPK-1) acts as a key transcriptional effector to preserve neuronal integrity, function, and #proteostasis during #aging."
" But once you experience #Mastodon, you suddenly realize just how much advertising, spam, and phishing you are being force-fed. I find Mastodon restful. Like the first time you realized that TV is possible without commercials. Also, because journalists and scientists are leading the charge to Mastodon, my feed seems to reflect a culture of knowledge, even leaning on peer-reviewed citations."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com