Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
RT @jwoodgett@twitter.com
Some thoughts on core facilities.
1. These are enormous all-boat lifters if supported well.
2. They should be run by experts who are commensurately valued and supported. This is a career path. Include names on papers if they’ve contributed insight, even if fee-for-service. /1
🐦🔗: https://twitter.com/jwoodgett/status/1613548511085166593
Thiago Carvalho
boosted
Our latest issue is full of wonderful #OpenAccess #DiseaseBiology science & a generous sprinkling of community spirit:
🦠Professors Pascale Cossart and Serge Mostowy reflect on Louis #Pasteur's legacy
🧠A Special article discusses the bench-to-bedside pipeline in #neuroscience
🐟A new way of seeing #disease processes in a transparent #fish D.cerebrum:
Tools
"For a CRISPR guide RNA (gRNA) with a specific target but activity at known "off-target" sequences, we present a method to screen hundreds of thousands of gRNA variants with short, randomized 5' nucleotide extensions near its DNA-targeting segment"
"Keaton had been on the stage longest, risen the highest, fallen the furthest, and, thanks to the medium of film which preserved his artistry, left the most indelible legacy. ‘He was,’ Orson Welles said, ‘as we’re now beginning to realise, the greatest of all the clowns in the history of the cinema.’"
John Lahr @lrb
https://www.lrb.co.uk/the-paper/v45/n02/john-lahr/puzzled-puss
Thiago Carvalho
boosted
Ever wondered whether GC-Tfh can be recalled upon secondary challenge? And if so, what cell type they become?
@Dr_Will_Foster
used S1PR2-ERT2 fate mapping to show that most are recalled to be Tfh cells again, but some become Th1 cells as well.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00409-8#figures
“Mucha gente de las Fuerzas Armadas conspiró aquí dentro. Estoy convencido de que la puerta del Palacio del Planalto [sede de la Presidencia] se abrió para que entraran porque no hay ninguna puerta rota. Es decir, alguien aquí les facilitó la entrada”, ha declarado Luiz Inácio Lula da Silva'
Thiago Carvalho
boosted
Genomes from incoming passengers from China to Italy shows bias for large hubs, and distribution of known omicron sublineages. Paper compares that with data submitted to GISAID https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.2.2300008
"In this short, the Australian journalist Kirsty B Carter interviews the US writer Matthew Goodman who explains how a series of stories, originally intended as satire and published in 1835 in the New York paper The Sun, convinced millions that the Moon was teeming with life – including, infamously, a race of bat-people."
"Care home operators are pressing the UK government for higher prices to take in NHS patients as they seek to tackle a staff shortage before the pressures become even more acute."
https://www.ft.com/content/a2ad1787-eb3c-4f21-b138-a12670d7aaa1
“I am convinced that the door to the Planalto palace was opened so these people could get in because I didn’t see the front door had been broken down. And that means that somebody facilitated their entry here,” Lula said'
https://www.theguardian.com/world/2023/jan/12/lula-bolsonaro-brazil-mob-presidential-palace
The horror:
"No terceiro trimestre do ano passado, os preços de venda das casas em Portugal aumentaram quase o dobro daquilo que se verificou no conjunto da zona euro"
"Whether Congress takes public health reform seriously could determine whether America can break out of the boom and bust cycle of funding preparedness efforts, and shape the field for the crises to come. But many reform advocates think an overhaul of the United States’ public health system may be years away, if it happens at all."
https://www.statnews.com/2023/01/11/will-americas-public-health-reckoning-ever-come/
Thiago Carvalho
boosted
« Dans la recherche, des découvertes de moins en moins révolutionnaires »
->Principe de dilution car bcp plus d’articles mais: « il y a toujours autant d’articles très disruptifs qu’avant »
Thiago Carvalho
boosted
RT @WEHI_research@twitter.com
Thrilled to have Professor Jacques Miller's milestone #thymus discovery featured in this @Nature@twitter.com video.
It's the incredible story of how two researchers from opposite ends of the world united to solve the B and #Tcell mysteries - watch 👇
https://www.youtube.com/watch?v=mzIuLF9MiSc
🐦🔗: https://twitter.com/WEHI_research/status/1612982207110610944
Thiago Carvalho
boosted
#Plasmamembrane topography governs the 3D dynamic localization of #IgM #Bcell #antigenreceptor clusters
Deniz Saltukoglu, Michael Reth et al at University Freiburg use high-resolution #microscopy on the #Burkitt’s Lymphoma model Ramos B-cell line to reveal surface topographical features facilitating screening of #antigens
Thiago Carvalho
boosted
For both those new to Octavia Butler and those who have been devoted fans of her writing for most or all their lives, this article by Lynell George is essential reading if you want to better understand the author, her work, and her tremendous legacy. But it's so much more than a read, thanks to the stunning 3D artwork contributed by Ainslee Alem Robson.
#OctaviaButler #reading #author #books #fiction #BlackCulture #scifi #writing #writingcommunity #bookstodon
https://www.nytimes.com/interactive/2022/11/17/arts/octavia-butler-vision-kindred.html
"To overcome the limitations of IL-2 as a therapeutic agent, two strategies have evolved: tumor-targeted rather than systemic delivery and engineered variants of IL-2 that preferentially activate IL-2-mediated signaling through the IL-2Rβγ heterodimeric receptor without concomitantly activating IL-2Rα (CD25) and consequentially amplifying Tregs. Both strategies have been incorporated into PD1-IL2v, a bispecific antibody molecule (dubbed an immunocytokine) that combines CD8+ T cell targeting via PD-1 binding with an IL-2 variant (IL2v) defective in binding to CD25."
https://www.cell.com/immunity/fulltext/S1074-7613(22)00642-2#.Y722Hd52BG0.twitter
Thiago Carvalho
boosted
The argument for markups over low production costs are often framed as "Sure, subsequent pills cost $3 to make, but the first one cost billions and we have to recoup that investment."
It's fair enough when the company foots the bill for the billions of dollars in applied research and development (including testing!) needed to build on basic research subsidized by the federal government.
But that's not really what happened with the covid vaccine.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
