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"As with many of Britain’s social ills, the architecture of today’s care system is a product of Thatcherism, essentially unaltered by the Blair administration: an archipelago of small firms, each owning a single care home, alongside huge chains backed by venture capital. Long-term NHS geriatric beds are gone, and local authority homes have almost vanished."

lrb.co.uk/the-paper/v45/n05/ja

An antibacterial peptide encoded in the mitochondrial genome ().

"We demonstrate that MOTS-c (mitochondrial open reading frame from the twelve S rRNA type-c) is a mitochondrial-encoded amphipathic and cationic peptide with direct antibacterial and immunomodulatory functions, consistent with the peptide chemistry and functions of known HDPs."

biorxiv.org/content/10.1101/20

"Here, we report that a high sugar diet reduces Drosophila female fertility by increasing death of early germline cysts (prior to follicle formation) and degeneration of vitellogenic follicles; that obesity in and of itself does not impair fertility; and that high glucose levels closely correlate with reduced fertility on a high sugar diet."

biorxiv.org/content/10.1101/20

This ⬇️ looks really interesting! Need to read it carefully (just screened it), but I immediately thought about the potential impact/implications (?) within the glyco-RNA discovery #glycotime #preprints @raflynn

"RNA scaffolds the Golgi ribbon by forming condensates with GM130"
qoto.org/@biorxivpreprint/1099

"In November 2021, Compass published its initial results from the study on people with treatment-resistant depression. A single dose of psilocybin, combined with therapy, was shown to have a significant effect in the short term, improving depression scores for 37 per cent of patients three weeks after the trial, with 29 per cent in remission."

ft.com/content/e8dbeaea-9b65-4

The plot, as they say, thickens:

'Rishi Sunak is refusing to rush Britain back into the EU’s €95.5bn Horizon science programme despite his recent breakthrough in relations with Brussels, raising the prospect of a tough negotiation on rejoining the scheme.'

ft.com/content/409bccc7-8cb4-4

“I simply wanted to recover the heritage – the ancient traditions and vines – left to us by our ancestors,” said Torres, the president of Familia Torres winery. “And then we realised that some of these varieties take longer to ripen, meaning they might be able to help us in a warming world.”

theguardian.com/world/2023/feb

Excited to present our work on measuring reproducibility of self-organized stem-cell assemblies in collab with @gregorscience at the #DevStem conference @ISTAustria today!

Many awesome talks and posters across the field lined up for this yearly Vienna conference!

'We have reached the point where scientists are warning not only that we are facing a mass extinction event, but that one is already under way. Can history — and not only human history — help us frame a response to the climate concerns of the modern age?'

ft.com/content/33e66ae3-dac2-4

RT @mrillig
Are you a female researcher with an interest in ecological synthesis, meta-analysis, quantitative methods, machine learning?
Please get in touch!
Making one appointment of a 2-year postdoc fellowship this year through the @AvHStiftung Henriette-Herz Program

A throwback piece on the Instituto Gulbenkian de Ciencia page about a small workshop that Miguel Soares & I organised on resistance and tolerance in 2010. This was back when most immunologists hearing "tolerance" would think only of T and B cell selection (and the occasional regulatory T cells). I'm a big fan of the small workshop, where everyone discusses unpublished work and feels free to speculate. We need more of these meetings.

gulbenkian.pt/ciencia/news/sci

Eight storytelling tips from one of my favorite writers. Here's #1:

"Use the time of a total stranger in such a way that he or she will not feel the time was wasted."


themarginalian.org/2012/04/03/

A milestone for a young field:

Our community recommendations for single-cell proteomics are published OA in Nature Methods

nature.com/articles/s41592-023

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