Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Preclinical study of anti-IL8 in endometriosis:
"We created a long-acting recycling antibody against IL-8 (AMY109) and evaluated its clinical potency. Because rodents do not produce IL-8 and do not experience menstruation, we analyzed the lesions in cynomolgus monkeys that spontaneously developed endometriosis and in a surgically induced endometriosis monkey model."
#Immunology #monoclonalantibodies #Endometriosis #inflammation
Thiago Carvalho
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With a beautiful view of the Canals
'Yet it is still early days for AI drug discovery. There are a lot of AI companies making claims they can’t back up, says Prakash: “If somebody tells you they can perfectly predict which drug molecule can get through the gut or not get broken up by the liver, things like that, they probably also have land to sell you on Mars.”
Thiago Carvalho
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Haruki Murakami on originality in art & literature (from "Novelist as a Vocation".
#books #writers #bookshelf #literature
Thiago Carvalho
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Postdoctoral position in ecology, evolution, and genetics of Dictyostelium discoideum and its bacteria
The Queller-Strassmann group at Washington University in St. Louis has a postdoctoral position for a highly motivated individual interested in exploring this fascinating microbial system. We will begin reviewing applications by March 20 and will continue to accept them until the positions are filled. Start date is flexible.
Thiago Carvalho
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Cis- and Trans-variations of Stearoyl-CoA Desaturase Provide New Insights into the Mechanisms of Diverged Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species https://doi.org/10.1093/molbev/msad015 #science #evolution #biology #genome #SciComm #evolgen_paper
@kevinng Here's the lab you want
Thiago Carvalho
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Tracing the origin of a group of ion channels important for neuronal communication sheds light on how these proteins evolved their role in the nervous system. https://elifesciences.org/digests/81613/making-new-with-old?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Thiago Carvalho
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Rest in power #WayneShorter, brilliant #jazz saxophonist and composer in Miles Davis' Quintet and Weather Report. *NO ONE ELSE* wrote melodies with the mature, reflective poignancy of tunes like "Iris." Thanks for all the beauty, Wayne. 🙏https://youtu.be/bVtVobH3GDo
@kevinng Point your collaborators to his example:
“It’s a wonderful piece because it offers the orchestra the opportunity to really shine rather than only accompanying”
Thiago Carvalho
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Had the chance to chat with Klaus Mäkelä, the 27 year-old conductor leading some of the world’s best orchestras
https://bachtrack.com/interview-klaus-makela-orchestre-de-paris-february-2023
Thiago Carvalho
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Excited that our paper is now online! @veraksa @Ken_Moberg We show that the Hippo pathway and its new member, TIF1/TRIM ortholog Bon, control cell fate decisions in the Drosophila eye via a non-canonical transcriptional program. 50 days of free access link: https://authors.elsevier.com/c/1ggtb5Sx5gtwIP. #DevBio #Drosophila #HippoPathway #GeneRegulation #PaperThread 🧵 1/8
Thiago Carvalho
boosted
The new tool MorphoFeatures allows researchers to automatically assign cell types and tissues in electron microscopy images, a step which is critical for understanding complex organisms. https://elifesciences.org/articles/86172?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights
Eight storytelling tips from one of my favorite writers. Here's #1:
"Use the time of a total stranger in such a way that he or she will not feel the time was wasted."
#KurtVonnegut
https://www.themarginalian.org/2012/04/03/kurt-vonnegut-on-writing-stories/
"Despite more than 40 years of responding to HIV and important breakthroughs in primary and secondary prevention, the rate of new infections is stuck at 35,000 per year, and racial disparities are worsening. Similar failures were apparent in the response to mpox last summer, with the most vulnerable communities once again bearing the brunt of a new viral threat. It is not too late to reverse course, but doing so will take political will and commitment. A new approach to accessing HIV preexposure prophylaxis (PrEP) could provide a blueprint for responding to other public health emergencies."
#publichealth
https://www.nejm.org/doi/full/10.1056/NEJMp2216100?query=featured_home
It represents an incredible advance, but the reality of cancer immunotherapy continues to be that for most patients and tumor types it will not provide the hoped-for response. Identifying predictive biomarkers is one key to improving outcomes.
"This study reveals dynamic cellular changes occurring during effective ICT and the role of a set of biomarkers connected to the cytotoxic potential of CD8+ T cells, which are instrumental in tumor immunity and could be used to assess the level of immunotherapy efficiency."
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00031-9
Thiago Carvalho
boosted
Dclk1+ cells in the intestinal epithelium 🔬 imaged by #immunofluorescence #microscopy
@failedLyndonLaRouchite And it can be used to generate hypotheses that can then form the basis of a study with controls, placebos, blinding etc
@failedLyndonLaRouchite As a biologist, I think of these as the equivalent of an old fashioned descriptive natural history study in botany or zoology. They are a very important part of the literature of the field, so long as you understand their limitations.
@failedLyndonLaRouchite It's a bit like case reports, which are a very important part of the medical literature, they are descriptive by nature (there is no control in these studies either)
@failedLyndonLaRouchite I think observational studies in medicine are valuable, as long as you understand their limitations. This is not interventional, so having a placebo (to refer to your other toot) does not really apply, as they are not testing any procedure or drug.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
