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Hi Mastodon folks. Twitter is getting quieter so I've clearly lost my previous @scotttishwaddell twitterverse. I'll start posting occasional lab news here too (instead) so please follow if that's of interest. We've lots in the pipeline and I'm missing learning about the other cool science out there that used to flash by my eyes on Twitter. Cheers, Scott. #Introduction #neuroscience #drosophila #dopamine

In an open letter by eight European leaders to #bigtech companies, we stress the urgent need to take more efficient steps against disinformation.

Social media should not be used to destabilise democracies. Tech platforms also have a responsibility to make sure it doesn't happen.

🐦🔗: n.respublicae.eu/kajakallas/st

UK politics 

Remember folks, you must definitely not mention any parallels between 1930s Germany and the current government's plans to round up the "other" people and concentrate them into camps, because the poor little snowflake Tory MPs get offended if you do and it will make them cry

#Asylum #Fascism

bbc.co.uk/news/uk-65107827

'In most cases, researchers rely on P values to establish the scientific or practical significance of their findings. However, statistical significance alone provides very little information that is useful for making inferences about scientific or policy significance. For this reason, we require authors to provide much more information than just P values — in this Editorial, we explain our requirements.'

nature.com/articles/s41562-023

Tregs move one step closer to the clinic - Regeneron is partnering with Sonoma ( founded by Bluestone, Rudensky, Ramsdell & Tang) targeting ulcerative colitis, Crohn's and "two other undisclosed indications".

investor.regeneron.com/news-re

'The Cancer Immunotherapy Data Science Grand Challenge, which ran on Topcoder from January 9 to February 3, aimed to uncover new ways to modify, or “perturb,” T cells to make them more effective at killing cancer cells to ultimately improve cancer treatment.'

broadinstitute.org/news/machin

"The induction of cellular cytotoxicity requires that the NK cell contacts its target cell and establishes a lytic immunological synapse. Previous reports have revealed that membrane protrusions may be a component of immune synapses. Here, we explored whether changes in the topology of intratumoral NK cell membranes relate to the formation of lytic immunological synapses."

nature.com/articles/s41590-023

"The revenue model of mega-journals is based entirely on charging article publication fees. The publishers increase these fees when a journal improves its impact factor ranking. The model secures high journal revenue but poses difficulties for authors with limited discretionary funds."

jamanetwork.com/journals/jama/

Postdoctoral Associate / Scientist Biochemistry and Molecular Cell Biology @Uni_WUE

Join us to study SMC #DNA motor complexes by single-molecule #Microscopy, #StructuralBiology and #CellBiology at the JMU Würzburg Biocenter.

...
jobrxiv.org/job/julius-maximil

I still have an open position for a 3 year postdoc in Berlin. If you’ve got grazing incidence X-ray scattering or diffraction experience and in-depth Python knowledge, please do not hesitate to apply! Lots of freedom, all the toys!

bam.de/umantis/EN/1523.html

Antisense oligos and personalised medicine.

"Susannah joins a small but growing group of patients who have received treatments designed just for them, called ‘N of 1’ therapies. Personalized medicine seemed to be just around the corner for decades, but in 2018, the corner had finally been turned when a custom-designed ASO made its clinical debut at Boston Children’s Hospital."

nature.com/articles/s41587-023

Good news and another great application of immunotherapy checkpoint inhibitors that helps T cells stay switched on to kill cancer

Women in England with advanced cervical cancer to be offered new treatment

theguardian.com/society/2023/m

'Hace tres meses, un hospital de Londres anunció que había utilizado los editores de bases para salvar la vida de Alyssa, una niña de 13 años con una leucemia muy agresiva.'

elpais.com/ciencia/2023-03-28/

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