Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Before creating slides, write down the main points you hope to communicate. These might include an overarching question, the reason that question is important, your key results and any remaining issues. Try to connect the points into a smooth half-page narrative with a beginning, a middle and an end."
Thiago Carvalho
boosted
A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage
Thiago Carvalho
boosted
'The Cancer Immunotherapy Data Science Grand Challenge, which ran on Topcoder from January 9 to February 3, aimed to uncover new ways to modify, or “perturb,” T cells to make them more effective at killing cancer cells to ultimately improve cancer treatment.'
Thiago Carvalho
boosted
#introduction #sciencemastodon #virology #hiking #biketooter #PNW
I am an Emeritus Professor at the Fred Hutch in Seattle (i.e., retired). My lab studied host-pathogen interactions, especially how HIV adapted to humans and how HIV latency is controlled. I also taught a graduate level virology class for several decades. I hike, bike, and garden in the Pacific Northwest and looking to add other hobbies and activities.
Thiago Carvalho
boosted
The road connecting Edo (Tokyo) and Kyoto, 1850 #utagawahiroshige #hiroshige https://www.wikiart.org/en/hiroshige/the-road-connecting-edo-tokyo-and-kyoto-1
PIEZO and NK cells
"However, the role of mechanosensing in regulating NK cell killing efficiency in physiologically relevant scenarios is poorly understood. In this study, we report that the responsiveness of NK cells is regulated by tumor cell stiffness. NK cell killing efficiency in 3D is impaired against softened tumor cells, while it is enhanced against stiffened tumor cells"
https://www.biorxiv.org/content/10.1101/2023.03.27.534435v1?med=mas
Thiago Carvalho
boosted
RT @lpachter
It's time to stop making t-SNE & UMAP plots. In a new preprint w/ Tara Chari we show that while they display some correlation with the underlying high-dimension data, they don't preserve local or global structure & are misleading. They're also arbitrary.🧵https://www.biorxiv.org/content/10.1101/2021.08.25.457696v1
Thiago Carvalho
boosted
If you're in London:
"Berthe Morisot, extraordinarily a footnote in Impressionist history until a decade ago, arrives at London’s Dulwich Picture Gallery for her first UK exhibition in 70 years. It’s a wonderfully sympathetic, intelligent, enlightening show, placing Morisot at the heart of French painting while allowing her individuality to shine."
https://www.ft.com/content/d18f89ef-81e0-4d76-8e27-6347c8c3b88b
'Here, we describe the molecular profile of a thermosensory neuron pair in C. elegans experiencing different temperature stimuli. We find that distinct salient features of the temperature stimulus, including its duration, magnitude of change, and absolute value, are encoded in the gene expression program in this single neuron type, and we identify a novel transmembrane protein and a transcription factor whose specific transcriptional dynamics are essential to drive neuronal, behavioral, and developmental plasticity.'
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00263-4
Thiago Carvalho
boosted
Trout may be able to save energy by swimming directly behind one another when in a school of fish. https://elifesciences.org/digests/81392/stay-in-school?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Thiago Carvalho
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RT @HHMIJanelia
🔥 We're #hiring imaging experts to help us develop the future of imaging science.🔥
Apply today for current openings in 🔬 instrumentation development, 🧪 sample preparation & biology, and 🖥️ image analysis & software development ▶️ https://www.janelia.org/careers/scientific-imaging-careers-available-at-janelia
#ScienceJobs
Ancient shade
'Indeed, an anecdote that arose in antiquity paints exactly this picture: Dionysius, on the eve of the split, requested that Plato not speak ill of him back at the Academy, prompting Plato’s haughty reply: ‘May the gods forbid that we have any reason to speak of you at all.’'
https://aeon.co/essays/what-the-controversial-letters-of-plato-reveal-about-us
Thiago Carvalho
boosted
Endosome sorting sorted!
In their Review, Vaishnavi Ananthanarayanan and Greg Redpath discuss recent studies on the regulation of endosomal vesicle positioning and transport by motors and adaptors.
'In this study, we show that reversal of methylation silencing of STING in murine melanoma cell lines using a clinically available DNA methylation inhibitor can improve agonist-induced STING activation and type-I IFN induction, which, in tumor-bearing mice, can induce tumor regression through a CD8+ T cell-dependent immune response.'
Thiago Carvalho
boosted
Did you know that you can find and post jobs on our job board? It’s free and easy to do. Check out the current list of available positions here: https://thenode.biologists.com/jobs/
Thiago Carvalho
boosted
Patti Smith reads Oscar Wilde's stirring letter on suffering and transcendence, penned while imprisoned for loving whom he loved https://www.themarginalian.org/2016/11/07/patti-smith-reads-oscar-wilde-de-profundis/
What could possibly go wrong?
"Big Tech companies have been slashing staff from teams dedicated to evaluating ethical issues around deploying artificial intelligence, leading to concerns about the safety of the new technology as it becomes widely adopted across consumer products."
https://www.ft.com/content/26372287-6fb3-457b-9e9c-f722027f36b3
Thiago Carvalho
boosted
@k4tj4 @r3rt0 @AleAliSousa @sofievalk
Wow, that's impressive: cerebellar cross-sections for 56 mammalian species, and data showing that "Ancestral estimations indicate that size and folding of the cerebrum and cerebellum increase and decrease concertedly through evolution."
"Diversity and evolution of cerebellar folding in mammals", by Heuer et al. 2023 https://www.biorxiv.org/content/10.1101/2022.12.30.522292v2
Question: does the pachyderm's (elephant) cerebellum also follow the proportionality rule with the cerebrum? I recall a commentary (Herculano-Houzel https://doi.org/10.1016/j.cub.2022.01.058 ) on how the elephant's cerebellum is 96% of all brain cells, when normally it's "only" 80%, at least in primates.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
