Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"In the case before the US Supreme Court, Amgen is appealing against a federal court ruling that struck down one of its key patents on Repatha. The patent claims not only a handful of specific antibodies, as defined by their amino-acid sequence, but also any other antibodies, regardless of their structure, that bind to the same region of the PCSK9 protein."

https://www.nature.com/articles/d41586-023-00911-7

"Collectively, our findings demonstrate HCMV reactivation in senescent cells, which CD4 CTLs can directly eliminate through the recognition of the HCMV-gB antigen."

https://www.cell.com/cell/fulltext/S0092-8674(23)00211-8

'Immunological adaptations occur in response to nutritional status: Undernutrition impairs immunity, causing inefficient responses to infections and vaccinations. Conversely, overnutrition favors chronic activation of both innate and adaptive immune cells, with subsequent (low-grade) systemic inflammation.'

https://www.science.org/doi/10.1126/science.ade0113

The silence of the lettuces

"Stressed plants show altered phenotypes, including changes in color, smell, and shape. Yet, airborne sounds emitted by stressed plants have not been investigated before. Here we show that stressed plants emit airborne sounds that can be recorded from a distance and classified."

https://www.cell.com/cell/fulltext/S0092-8674%2823%2900262-3?dgcid=raven_jbs_etoc_email

"The data had been temporarily obscured pending what Gisaid said were “newer and additional data as part of a manuscript under review” by Chinese CDC researchers. But the restoration of access will help scientists globally discern whether the findings on a potential zoonotic link, first reported in The Atlantic, offer a credible theory on the pandemic’s origins."

https://www.ft.com/content/f0733683-cb6d-4578-915a-aa60d7ba4c1d

'In detailing Eratosthenes’ ingenious methods, Sagan provides a fascinating science history lesson that doubles as a tribute to the remarkable ingenuity of ancient thinkers, who were able to uncover extraordinary truths with the simplest of tools.'

https://aeon.co/videos/how-an-ancient-polymath-first-calculated-earths-size-as-told-by-carl-sagan

"Hours before his departure for Brazil, federal police summoned him to give evidence on April 5 in an investigation into at least two sets of jewellery, worth millions of dollars, given to the president and his family purportedly by the Saudi government."

https://www.ft.com/content/e261421c-905e-47fd-8918-b12b128cadea

"In a 2004 paper, the World Health Organization’s former director of evidence, Chris Murray, and other researchers described the agency’s estimates as “serial guessing.” Without that baseline data, progress toward any given goal — to halve hunger, for example — could not be measured."

https://www.nytimes.com/2023/03/29/magazine/birth-death-tally.html

Gut tregs:

"Thus, Helios+ effector tTregs proliferate via CD28 and require neither ICOS nor MHCII for maintenance. In contrast, RORγt+ pTregs utilize CD28 and ICOS."

cc @mucida

https://www.mucosalimmunology.org/article/S1933-0219(23)00017-X/fulltext