Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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The field of synthetic biology has come a long way in the past 20 years. In this Perspective, @MatthewWChang &co at @nus_syncti look at how #machinelearning could help synthetic biology to achieve greater heights. #synbio
https://plos.io/3LbB7y6
Thiago Carvalho
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RT @williamnhutton
Ultra expensive housing is killing our civilisation- denuding cities of the young, making starting families ever harder, impacting the birth rate and hitting economic growth and social mobility. Hear Polly Neate on the We Society podcast set out the issues - and some answers https://twitter.com/acadsocsciences/status/1651499251585744897
Thiago Carvalho
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RT @denis_mogilenko
Systems Immunology Approaches to Metabolism – check out our new review in @AnnualReviews of Immunology! We discuss recent studies highlighting the complex physiological interplay between immune responses and metabolism.
https://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-101220-031513
Thiago Carvalho
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RT @solana_jordi
Proudly presenting our new bioRxiv:
The cell type atlas of the regenerating and asexually reproducing annelid Pristina leidyi
We show that a piwi+ cell population with a pluripotent stem cell signature underlies adult differentiation
https://www.biorxiv.org/content/10.1101/2023.04.25.537979v1
A tweetorial 🧵👇
Thiago Carvalho
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Aquatint & chine-collé with colours added through viscosity printing by @madparreira
https://madalenaparreira.com/Aquatints
#Prints #Printmaking #Print #artofinstagram #Aquatint
#Handmade #chinecollé #artmastodon
Thiago Carvalho
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PhD position - Molecular mechanisms of airway mucin secretion
PhD opportunity - Molecular mechanisms of airway mucin secretion
#ScienceJobs #job
Ulm #Germany #PhDStudent
https://jobrxiv.org/job/university-of-ulm-27778-phd-position-molecular-mechanisms-of-airway-mucin-secretion/?feed_id=43722
Thiago Carvalho
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An Interlude in Microbiology
by Elio
If before 1950 you had asked "are bacteria cells?" the chances are that you would be told "it depends…" In other words, no one knew for sure. It took Joshua Lederberg, who, upon discovering mating in E. coli, proposed that bacteria were indeed cells...
Read more → https://schaechter.asmblog.org/schaechter/2023/04/an-interlude-in-microbiology.html
Thiago Carvalho
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Corvos imaginários, papagaios estocásticos e outros animais que falam, de Manuel Arriaga, pretende apresentar algumas ideias em torno do tema ChatGPT, indo um pouco além das discussões que geralmente se encontram nos media:
https://almanaquemag.com/corvos-imaginarios-papagaios-estocasticos-e-outros-animais-que-falam/
📸 Alessio Ferretti
#almanaque #almanaquemag #manuelarriaga #chatgpt
Thiago Carvalho
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SSB is launching a new mentorship program to cultivate relationships among members of the systematics and phylogenetics community.
We're now recruiting a pool of mentees and mentors for our first group of participants!
Learn more: https://www.systbio.org/mentoring-program.html
Enroll here: https://forms.gle/mc2gPDwaTGYvcR1k7
'A key feature of the accelerated approval system is that manufacturers are required to conduct post-approval studies to demonstrate the drug’s therapeutic value. Among 93 cancer drug indications granted accelerated approval between 1992 and 2017, confirmatory trials reported an overall survival improvement in only 20% of them.'
'Discounts or rebates (a subcategory of so-called “managed entry agreements”) on drug prices are negotiated between governments and manufacturers, and a growing number are confidential.7 Confidential rebates are especially applied to cancer drugs.8 In consequence, countries using the external reference pricing system overestimate actual prices, triggering an upward spiral of drug prices.'
Thiago Carvalho
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Postdoctoral Fellow
The de Cubas Lab in the Department of Microbiology & Immunology at the Medical University of South Carolina and the Hollings Cancer Center has an open
#ScienceJobs #job #CancerImmunology
Charleston #U...
https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=43710
'After a public dispute with NPR, which Twitter falsely labeled state-affiliated media, the platform last week removed all labels that had identified state-owned media, including those controlled by authoritarian states like Russia, China and Iran.'
https://www.nytimes.com/2023/04/26/technology/twitter-verification-problems.html
Thiago Carvalho
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RT @NatMetabolism
Online now! Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction http://dlvr.it/Sn6VKR
Thiago Carvalho
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New preprint from Geert Kops and co. on the role of CENP-E in building the kinetochore corona expansion. I've always been intrigued by the farnesyl (lipid) modification on CENP-E, identified years ago by Stephen Taylor's lab. This new preprint suggests that this modification and CENP-E have a structural (non-motor) role in stabilising corona expansion.
https://www.biorxiv.org/content/10.1101/2023.04.26.538394v1.full
Thiago Carvalho
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Structure determination of a DNA crystal by MicroED - 1.1Å Resolution, nice.
@strucbio #crystallography #MicroED #structuralBiology #Science
http://biorxiv.org/cgi/content/short/2023.04.25.538338v1?rss=1
Thiago Carvalho
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"Transplantation of hNSCs has been shown to increase the number of CD4+CD25+Foxp3+ T regulatory cells (Tregs) in the spinal cords of murine models of MS, which is correlated with a strong localized remyelination response. However, the mechanisms by which hNSC transplantation leads to an increase in Tregs in the CNS remains unclear."
'In briefing documents published ahead an advisory committee meeting, FDA staffers argue that in metastatic castration-resistant prostate cancer (mCRPC), Lynparza has only showed a favorable benefit-risk profile in patients with BRCA mutations.'
Thiago Carvalho
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Paired peripheral and central blood cultures are worth it!
#IDMastodon #MedMastodon #medicine #microbiology
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad225/7123639
Thiago Carvalho
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@cyrilpedia Their observations show no change in the percentage of total #tumor associated #macrophages (TAMs) in the tumor tissue but a markedly increased percentage of NOS2+TAMs with no significant changes in arginase I expression...raising the question, which cell type would be the corresponding human counterpart? Macrophage or #monocyte ?
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
