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'In conclusion, differences in hepatocellular iron handling between male and female account, at least in part, for sexual dimorphism in induced ferroptosis of the hepatocytes.'

biorxiv.org/content/10.1101/20

'If height is an indicator of social conditions in childhood, including nutrition, is it possible that social conditions for children in the UK are worse than in many other countries and deteriorated during the decade after 2010?

It is highly plausible.'

theguardian.com/commentisfree/

🚨NEW PREPRINT🚨
Michael Smutny's lab have a new paper on bioRxiv on the mechanics of the early neural plate. Check it out!

Inman et al.
A multi-tiered mechanical mechanism shapes the early neural plate

biorxiv.org/content/10.1101/20

#DevBio #cellbiology #biorxiv #papertoot #biophysics

Neuroscience vs Philosophy

'For many years, the bet was mostly forgotten. That is, until a few years ago, when it was resurfaced by Per Snaprud, a science journalist based in Stockholm who had interviewed Chalmers back in 1998. His recording of the chat reminded the pair of the terms they had set in the wager and the case of wine that was at stake.'

nature.com/articles/d41586-023

"As we embark on the journey for a First Nations Voice, the conversations we all have with our family, friends and work mates will be vitally important.

We're answering the major questions, to help you feel informed and comfortable to have those conversations."

From yes23.com.au/

'You might think you should run to one of England’s small villages, away from the densely packed medieval city. Don’t. While fleeing the city would be a wise choice when faced with most pathogens, human density doesn’t dictate the bubonic plague’s spread. Instead, it’s the ratio of fleas to humans that matters most. The result is that most rat-infested farming villages had higher mortality rates than England’s cities.'
(via The Browser)

smithsonianmag.com/history/cou

June 26, 1824, birthday of physicist William Thomson, better known as Lord Kelvin. His used thermodynamics to calculate #Earth's age* even if #geologists complained that "physics cannot be applied to #geology"* (*not exactly true) ⏰

americanscientist.org/article/

@Odedrechavi @marcrr Every organism is named according to the narrowest well-known taxonomic group it shares with humans.

A chimp is a primate, a mouse is a mammal, a zebrafish is a vertebrate, a lancelet is a chordate, a fly or worm is a metazoan, and trypanosomes or plants are eukaryotes.

This really weird title for a C. elegans scRNA-seq atlas reminds me of @Odedrechavi who said that "metazoan" in a paper abstract means the work is about fly or nematode.
science.org/doi/10.1126/sciadv
#SingleCell #nematode #Metazoa

“It’s stunning,” says the immunologist Barney Graham, the former deputy director of the Vaccine Research Center and a central figure in the development of mRNA vaccines, who has lately been writing about a “new era for vaccinology.” “You cannot imagine what you’re going to see over the next 30 years. The pace of advancement is in an exponential phase right now.”

nytimes.com/2023/06/23/magazin

Controlling for false discoveries subsequently to large scale one‐way ANOVA testing in proteomics: Practical considerations | analyticalsciencejournals.onli #proteomics

"Scientists warn that even a slight 0.8C (1.5F) increase in global #ocean temperatures represents “an enormous amount of #heat, large enough to transform marine #biodiversity, change ocean chemistry, raise #SeaLevels and fuel #ExtremeWeather”. "

theguardian.com/commentisfree/

Once someone makes the underlying assumptions explicit, you know what's coming next. Buckle up, tissue resident cell fate mapping, it's going to be a bumpy ride:

"Fate-mapping studies using conditional reporter genes and regulated expression of cre recombinase have led to the view that most resident tissue macrophage populations are established during embryonic development and maintained in the adult by self-renewal with minimal input from bone marrow progenitors or blood monocytes. The interpretation of fate-mapping studies depends upon multiple assumptions: (i) that expression of cre recombinase has no effect on monocyte-macrophage homeostasis, (ii) that tamoxifen is a neutral agonist, (iii) that life in an SPF animal facility reflects the normal life course of a mouse, and (iv) that the C57Bl/6J inbred mouse is a generalizable model and the biology of the MPS is unaffected by mouse genetic background or species."

onlinelibrary.wiley.com/doi/10

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