Thiago Carvalho @cyrilpedia@social.cleverlibre.org

LAG3 ICIs

"With this approval, LAG-3 became the third checkpoint inhibitor to show efficacy when targeted in the clinic, The response profile of Opdualag is comparable to the ipilimumab/nivolumab (anti-CTLA4/anti-PD-1) combination (47.7% versus 49% 12-month PFS), although 59% of patients had severe adverse events with ipilimumab/nivolumab compared with only 18.9% with Opdualag"

#immunology #Immunotherapy #checkpointinhibitors

https://www.nature.com/articles/s41590-023-01569-z

"Joining animals together, known as parabiosis, has a long history in science. In the 19th century, French scientists connected the blood vessels of two rats. To prove that the rats shared a circulatory system, they injected belladonna, a compound from the deadly nightshade plant, into one of the animals. The pupils of both rats dilated."

https://www.nytimes.com/2023/07/27/health/mice-blood-aging.html

As long as they cough up their share of the rent

"In June a Paris official made an announcement: the city would form a committee to look into the prospect of “cohabitating” with rats."

https://www.nybooks.com/articles/2023/08/17/whack-a-rat-the-rats-of-paris-vergopoulos/

BCMA targeting CARTs in #MultipleMyeloma

"At a median follow-up of 15.9 months (range, 0.1 to 27.3), the median progression-free survival was not reached in the cilta-cel group and was 11.8 months in the standard-care group (hazard ratio, 0.26; 95% confidence interval [CI], 0.18 to 0.38; P<0.001). Progression-free survival at 12 months was 75.9% (95% CI, 69.4 to 81.1) in the cilta-cel group and 48.6% (95% CI, 41.5 to 55.3) in the standard-care group."

#Immunology #immunotherapy #cartcells

https://www.nejm.org/doi/full/10.1056/NEJMoa2303379?query=featured_home

"Maps 1 & 4 The Conan Map (Brest, France, 16th Century)

This Renaissance print is a copy of a vellum drawn circa 1156 at the behest of Conan IV (“the Black”), Duke of Brittany, during a dynastic dispute with King Henry II of England, who was also Count of neighboring Anjou. As shown in the inset, the image’s purpose is solely to assert power and legitimacy. The multiple lines shown in the inset (the only remaining panel of a set of three) proclaim the conquest and rule of the corresponding regions by the Duke and his kinsmen in the House of Penthièvre."

#Art #Print #Printmaking #Etching #Handmade #Cartography#ArtGallery #Maps #artmastodon

https://madalenaparreira.com/SPAM

@NicoleCRust @DrYohanJohn

A big problem is that the field has always been dominated by a focus on physics - whether or not you agree with it, a small book I recommend is Mayr's 'What Makes Biology Unique'

Comparing autoimmune disease and the autoimmune side effects of checkpoint inhibitor therapy.

'Here, we compared T cells from the joints of 20 patients with an inflammatory arthritis induced by ICI therapy (ICI-arthritis) with two archetypal autoimmune arthritides, rheumatoid arthritis (RA) and psoriatic arthritis (PsA).'
#immunology #immunotherapy #autoimmunedisease #checkpoint

https://www.science.org/doi/10.1126/sciimmunol.add1591

'Radick uses counterfactual history to perform an experiment. He outlines a curriculum for an introductory biology class that does not begin and end with Mendelian inheritance, but instead emphasizes developmental contexts. Students who took this class — Radick ran the experiment at the University of Leeds, UK — came away with a less gene-centred and a more enquiring approach to biology than did those who took a more Mendel-focused course (A. Jamieson & G. Radick Sci. Educ. 26, 1261–1290; 2017).'

https://www.nature.com/articles/d41586-023-02310-4