Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Imitating each hormone individually can lead to weight loss, Tschöp says. But together, they work synergistically to keep each other in check. GIP activation suppresses GLP-1 activation’s side effects, and both of these hormone copycats stimulate insulin, preventing glucagon from raising blood glucose too high.'
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Not-so-creepy crawlies
Biotech is embracing insect protein as a meat alternative. Will the rest of the population follow? https://go.nature.com/3DFtzA3
Thiago Carvalho
boosted
Research Associate - Evrony Lab (NYU)
NYU - Evrony Lab
Come do exciting science at the Evrony Lab (NYU) as a Research Associate
See the full job description on jobRxiv: https://jobrxiv.org/job/nyu-evrony-lab-27778-research-associate-evrony-lab-nyu/?feed_id=53658
#ScienceJobs #hiring #research #genomics
New York City #UnitedStatesUS #ResearchTechnician
https://jobrxiv.org/job/nyu-evrony-lab-27778-research-associate-evrony-lab-nyu/?feed_id=53658
Thiago Carvalho
boosted
"Gov. DeSantis’ threat to ‘start slitting throats’ of federal employees is dangerous, disgusting, disgraceful, and disqualifying,” says AFGE President Everett Kelly. “No federal employee should face death threats from anyone, least of all from someone seeking to lead the U.S. government.” https://www.govexec.com/management/2023/08/desantis-vows-start-slitting-throats-federal-workers-day-one-presidency/389093/
'Most people who cast a ballot in the 2016 election voted against Trump for president. But in the American system, not all votes are equal. Instead, the rules of the Electoral College gave a small fraction of voters in a few states decisive say over who would win the White House. The will of the majority of the people as a whole — or at least the majority of those who went to the polls — meant nothing compared with the will of a select few who, for reasons not too distant from chance, could decide the election.'
https://www.nytimes.com/2023/08/04/opinion/trump-indictment-jeffrey-clark-insurrection-act.html
“Ah, o Papa Francisco teve um encontro com vítimas de abusos sexuais logo no primeiro dia de visita a Portugal? Mas em Oeiras seguimos outra orientação: retiramos a memória das vítimas do espaço público e fazemos de conta que está tudo bem.”
https://www.publico.pt/2023/08/04/opiniao/opiniao/oeiras-recordar-sofrimento-ilegal-2059148
Thiago Carvalho
boosted
Thiago Carvalho
boosted
According to the UN’s most recent climate assessment, temperatures today are on average higher than at any time in at least the last 100,000 years.
Given the burning of fossil fuels and clearing of land over the course of a century or so has pushed the climate beyond anything known by human civilisation, that is a long way from being meaningless.
#climateChange #climateCatastrophy #climateEmergency #climateBreakdown #tippingPoint
"This study highlighted a primordial PD-L1/BTLA coinhibitory axis that regulates CD8+ T cell activation in teleost fish and may act as an alternative to the PD-L1/PD-1 axis in mammals. It also revealed a previously unrecognized strategy for E. tarda immune evasion by inducing CD8+ T cell tolerance to target Mϕ cells through eliciting the PD-L1/BTLA checkpoint pathway."
#Immunology #zebrafish
Thiago Carvalho
boosted
The US American South and the "Lost Cause" of the Confederacy
@oliphant
Stuff I never learned in my History classes. And depending on where you lived, other states lied about this history.
Articles of Secession: https://web.archive.org/web/19980128034930/http://sunsite.utk.edu/civil-war/reasons.html
From this thread: https://hachyderm.io/@mekkaokereke/109789295728917242
"...I would get so mad at dudes I knew that downplayed the confederate flag, until I realized that their textbooks literally lied about the reasons for the civil war!
Showing them the articles of secession blew their mind. Some stopped rocking the flag.
Imagine how much less racist the US would feel if 10% of all confederate flags just disappeared."
Thiago Carvalho
boosted
What is mind/brain reductionism, in practice?
In Kandel's 2005 book, he lays out 5 tenants to "outline an intellectual framework designed to align current psychiatric thinking and training of future practitioners with modern biology". I regard this as a good snapshot of the "reductionism" that many quibble with, as it is practiced by the neuroscientists who adopt it. Would anyone disagree (either that this is reductionism or that this is a good snapshot of it?). Here are the principles.
Principle 1. All mental processes derive from operations of the brain.
Principle 2. Genes and their proteins are important determinants of the pattern of interconnections between neurons and how neurons function.
Principle 3. Alerted genes do not, by themselves, explain all of the variance of a given major mental illness. Social or developmental factors also contribute very importantly. Just as combinations of genes contribute to behavior, including social behavior, so can behavior and social factors exert actions on the brain by feeding back upon it to modify the expression of genes and thus the function of nerve cells. Learning, including learning that results in dysfunctional behavior, produces alterations in gene expression. Thus all of "nurture" is ultimately expressed as "nature".
Principle 4. Alternations in gene expression induced by learning give rise to changes in patterns of neuronal connections. These changes ... are responsible for initiating and maintaining abnormalities of behavior that are induced by social contingencies.
Principle 5. Insofar as psychotherapy or counseling is effective and produces long-term changes in behavior, it presumably does so through learning, by producing changes in gene expression ...
https://psycnet.apa.org/record/2005-05732-000
(Also available at archive.org).
"COVID-19 mRNA vaccination in pregnant people aids in preventing maternal SARS-CoV-2 infection and reduces risk of common adverse birth outcomes, with the booster conveying additional protection. We therefore recommend that pregnant people not only be vaccinated against COVID-19, but also stay up to date with their vaccination schedule."
#COVID #Covid19
https://www.thelancet.com/journals/landig/article/PIIS2589-7500(23)00093-6/fulltext
'According to Calvino, literature will continue to flourish in the next one thousand years and these six lines of literary heritage will expand far and wide. I have always liked Calvino and after reading this book, I like him even more.'
https://lithub.com/wang-xiaobo-on-the-limitless-mind-of-italo-calvino/
'We detected frequent introductions of multiple SARS-CoV-2 lineages in white-tailed deer, which subsequently became enzootic and co-circulated, and certain lineages persisted in white-tailed deer even after their decline in human populations. In addition, three cases of potential spillover from white-tailed deer back to humans were identified.'
Thiago Carvalho
boosted
ProMED warned the world about SARS, MERS and Covid-19. Now experts worry its future is in peril. https://www.statnews.com/2023/08/03/promed-early-warning-system-on-disease-outbreaks-appears-near-collapse/
"Mortality is contested ground, a place where different types of knowledge are in conflict. In Clark County, Nevada, for example, coroners spend weeks investigating possible heat-related deaths."
https://www.theatlantic.com/health/archive/2023/08/the-enigma-of-heat-related-deaths/674911/
'Proliferating cell nuclear antigen is critical to DNA replication and repair processes. Through a rational drug design approach, we identified a small molecule PCNA inhibitor, AOH1996, which selectively kills cancer cells.'
#Cancer
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00221-0
'The results indicate that there must be several different origins of these organic materials, and that the distribution and character of these on Mars is more complicated than we thought.'
https://www.science.org/content/blog-post/organic-compounds-all-over-mars
'Computerised chemical design is now well established, as AI drug discovery makes rapid progress in the pharmaceutical industry. What makes Chemify stand out, according to Cronin, is the way its “chemputer” technology extends to manufacturing the newly invented molecules.'
https://www.ft.com/content/be25204a-6ad6-4db5-bbf5-f819954d0ce5
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
