Thiago Carvalho @cyrilpedia@social.cleverlibre.org

M. #tuberculosis (Mtb) resists killing by repressing the #autophagolysosome machinery. @imgsb show that NCoR1 regulates these processes in myeloid cells by fine-tuning ATP homeostasis via AMPK-mTOR-TFEB axis, so controlling Mtb #pathogenesis #PLOSBiology https://plos.io/3quNEGD

Watercolor of a malignant growth springing from the eye of a woman, 19th century. The eye protruded for two months. In the righthand corner, you can see a monochrome sketch of the eyeball and tumour after its removal. [Image: Wellcome Collection] #histmed #histodons #histodon #history #medhist #histsci #illustration

Analysis of superspreading was crucial for COVID (and for many other outbreaks). As part of Epiverse we've therefore been collating functionality to easily interpret and summarise key features.

Feedback/contributions/suggestions welcome! See here for more: https://epiverse-trace.github.io/superspreading/

#IDMastodon @cdcgov Effectiveness of Monovalent and Bivalent #mRNAvaccines in Preventing #COVID19 Associated ED & Urgent Care Encounters Among Children Aged 6 Months–5 Years .VISION Network 🇺🇸 Jul 22–Jun 23
https://www.cdc.gov/mmwr/volumes/72/wr/mm7233a2.htm

'HIV is the easy part now — it’s all the aging stuff that’s coming up, but we hit those markers earlier than people who are not living with HIV. We’re classified as the silver generation, because we’re really the first generation of long-term survivors. So a lot of this is new to everybody. It’s new to the patients, it’s new to the providers. So we have to take a step back every now and then just realize we’re all learning this together.'

https://www.nejm.org/doi/full/10.1056/NEJMp2307347?query=featured_home

If you're UK Apocalypse Horsemen watch, here's one:

"Private equity firms have bought up dozens of UK healthcare companies including ambulance fleets, eye-care clinics and diagnostics businesses over the past two years"

https://www.ft.com/content/94184d66-517b-4893-8e06-df16efd135b3

‘Kind of Blue’. Released August 17, 1959.

#jazz #otd #MilesDavis #MastodonMusic

'Of note, CD20+ T cells are enriched in individuals with MS and in mice with experimental central nervous system (CNS) inflammation, and they have a highly activated phenotype2,3. In a recent publication, we provide evidence that these CD20+ T cells develop by an undirected transfer of B cell membrane termed trogocytosis, which takes place when B cells activate T cells during antigen presentation'

https://www.nature.com/articles/s41577-023-00920-7?utm_source=dlvr.it&utm_medium=twitter

'As a child, I was taken to see an animated film version of George Orwell’s novel “Animal Farm.” Much too young to understand that I was watching an allegory about Stalinism, I assumed that Orwell was a sort of downbeat Disney, making scary kids’ cartoons featuring brutal, dictatorial pigs and overworked horses sent to slaughter.'

https://www.washingtonpost.com/books/2023/08/16/orwell-animal-farm-wife-biography/

'Prof Danny Altmann, an immunologist at Imperial College London, said: “JCVI have done their calculation in favour of a very limited vaccine offer for the elderly and immunosuppressed, leaving the bulk of the population way out from their last dose and poorly protected.”

https://www.theguardian.com/world/2023/aug/17/covid-vaccines-should-be-available-privately-uk-scientists-say?CMP=Share_iOSApp_Other

"But when Damon is asked if he would have approved Oppenheimer’s clearance again in 1954, he said no, but that he also wouldn’t approve clearances for any of the other scientists on the project. He had figured out from hanging around with these characters for three years that scientists couldn’t keep scientific findings to themselves."
@holden

https://holdenthorp.substack.com/p/oppenheimer-shows-scientists-humanity?r=nm6fe&utm_medium=ios&utm_campaign=post

First in human trials of a CART cell using a llama single domain ab construct targeting mesothelin in solid tumors.

#Immunology #Immunotherapy

https://www.nature.com/articles/s41591-023-02452-y

"Ventura divulgou factos falsos com o conhecimento de o serem e fê-lo de forma deliberada e apta a enganar as pessoas e - desta vez - com a agravante de ter feito passar os conteúdos que divulgou por notícias da Renascença e do PÚBLICO. E a divulgação que fez foi massiva. Isto merece tutela penal."

https://www.publico.pt/2023/08/16/opiniao/opiniao/andre-ventura-politico-mentiroso-2060310

"(...) the sole surviving manuscript of the Ethics was deposited in the archives of the Roman Inquisition by Steno, who also submitted an indictment of his former friend to the Inquisitors. They did their work well: their subsequent investigation provides one of the main sources for Spinoza’s life. "

https://thecritic.co.uk/issues/august-september-2023/a-brilliant-biography-of-an-elusive-genius/

The preclinical work on CD47, which binds SIRPα to deliver a 'don't eat me signal', was very compelling. But as a druggable target it's had a bumpy ride in clinical development.

'Pfizer executives were bullish during a second quarter earnings call Thursday that its two CD47 meds would not face the same setbacks seen from rivals Gilead and others. As a result, the New York pharma is staying the course.'
(HT Michael Tomasson)
#Immunology #immunotherapy #InnateImmunity

https://www.fiercebiotech.com/biotech/pfizer-undeterred-cd47-plans-competitors-face-pitfalls

We are delighted to welcome Renata Basto, Kairbaan Hodivala-Dilke and Megan King as new Editors at Journal of Cell Science.

Read more in the Editorial from our Editor-in-Chief Michael Way, including the importance of journal reputation: https://journals.biologists.com/jcs/article/136/16/jcs261519/325896/Say-hello-wave-goodbye

Thanks to Maria Carmo-Fonseca, David Glover and Arnoud Sonnenberg, who are stepping down as Editors, for their many years of service for the journal.

Health care CEOs hauled in $4 billion last year as inflation pinched workers

https://www.statnews.com/2023/08/17/health-ceo-salaries-compensation/?utm_medium=social&utm_source=mastodon&utm_campaign=mastodon_organic