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"The insect compass system: From theory to circuitry" by Vilimelis et al. 2023 biorxiv.org/content/10.1101/20

Interesting insight on extra-genomic contributions to neural circuit architecture:

"we demonstrate that our predicted circuit can emerge naturally using Hebbian plasticity, which means the neural connectivity does not need to be explicitly encoded in the genetic program of the insect but rather can emerge during development."

And particularly:

"we now address another question: whether there might be a reason that insect head direction circuits typically have an eight-column architecture [...] powers of two are easier to generate with replication dynamics than other numbers, because they just require each cell to divide a set number of times."

"The circuits for N = 2 and N = 4 are degenerate – either producing a single dimensional encoding, or two disconnected circuits that do not enforce the required circular topology. N = 8 is the smallest power of two that could result in a non-degenerate circuit. This hints at the possibility that the eight-column architecture is not a chance evolutionary artefact, but rather that it is the genetically simplest circuit capable of performing heading integration."

#neuroscience #Drosophila #CentralComplex

'Neisseria gonorrhoeae is a leading cause of sexually transmitted disease and a concern due to increasing AMR. It contains a restricted repertoire of plasmids, including a conjugative plasmid, pConj, which disseminates plasmid-mediated AMR. We show that, in contrast to broad host range plasmids, pConj is largely restricted to and adapted to N. gonorrhoeae, and has been remarkably conserved since it first emerged over 80 years ago.'

journals.plos.org/plosgenetics

@PapyrusBrigade

A group of american disability advocates made a short film about how bikes & trikes work well for people with a wide range of disabilities.

usa.streetsblog.org/2020/07/27

In a mouse breast cancer model

"Age had no effect on tumor growth but increased lung and liver metastasis after 16 weeks. Obesity increased tumor growth starting at 12 weeks, increased liver metastasis only at 4 weeks, and weight gain correlated to increased lung but not liver metastasis"

biorxiv.org/content/10.1101/20

So now the deadbird site, formerly known as Twitter, is inviting developers to come back and "build what's next" with the much abused API.

Twitter (and Reddit)'s greed-infused API restrictions wrecked a project we (ASU News Co/Lab) were doing to help journalists send corrections down the same social media pathways as the original journalism.

The idea what we'd ever work with them again is a sick joke.

'Pulse oximeters routinely overestimated levels of oxygen in the blood in darker-skinned Covid patients, leading to delays in treatment and hospital readmissions, according to a research article published on Thursday.'

nytimes.com/2023/08/24/health/

🚀 Exciting News! Join us for a transformative Math Summit sponsored by the Institute of Education Sciences (@IESResearch). Let's improve #math outcomes for our children! 📚 Mark your calendars for Sept 12, 19, & 26. Register now: #education registration.socio.events/e/ie
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Great news: Free KN95 masks are now available from public health vending machines in NYC.

This is amazing work! Not everyone can afford to buy high quality masks regularly. If we want more people to wear masks, high quality masks should be available for free everywhere. Having them in public health vending machines in NYC is a great first step!

Emulsifiers are widely present in ultra-processed foods. A new #PLOSBiology study reveals that, in mice, maternal #emulsifier consumption during gestation and lactation leads to metabolic and neural impairments in the offspring. #metabolism #diet
plos.io/3YRBjbX

Mangrove #killifish are usually solitary but Chloe Melanson Simon Lamarre & Suzanne Currie found that having social experiences helps them stay in warm waters longer before leaping out in search of a new home

journals.biologists.com/jeb/ar

Read the full research here:
journals.biologists.com/jeb/ar

#biology #Zoology #science

Come join us! Lots of interesting livestock virus sequencing and genomics projects!

Research Technician, Bioinformatics | The Pirbright Institute
pirbright.ac.uk/jobs/research-

In 1975, Icelandic women earned 40% less than men; today it is only 10%. A "Women's Day Off" strike was held in 1975; 90% of women refused to work. It shut down the country. In response Iceland passed a Gender Equality Act & elected a female president.
vox.com/videos/23842984/icelan

I've gone through 3 million manuals in the Internet Archive's collections and produced a "Manuals Showcase", a few dozen manuals that are sure to catch your eye here and there. Readable online, downloadable, and ad-free.

archive.org/details/manuals_sh

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