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Closing a loop: The entire modern field of regulatory T cells emerged from the ashes of the suppressor T cell field because of experiments showing destruction of the reproductive system following neonatal thymectomy.

"We found that Treg depletion induces severe autoimmune orchitis and epididymitis, manifested by an exacerbated immune cell infiltration [CD4 T cells, monocytes, and mononuclear phagocytes (MPs)] and the development of antisperm antibodies (ASA)."

pnas.org/doi/10.1073/pnas.2306

A woman walks up a hill in Lanzarote, 2006. The sun is beating down, but she'll be walking into the small shade afforded by the wall of a house.

inphotos.org/2023/09/08/from-l

#Lanzarote #CanaryIslands #StreetPhotography #Photo

In #JapaneseFolklore rokurokubi are a type of #yokai appearing as regular women but with the ability to extend their necks to extraordinary lengths (or sometimes completely detach) so their heads can wander around without their bodies. Most rokurokubi just scare people rather than being dangerous. It is believed they were once real women who were transformed into yokai as a result of either a curse or punishment. I have written more about them here: curiousordinary.com/2023/06/ro
#folklore @folklore

"Why aren't people leaving Twitter?" - I had a call today with a colleague in Europe who manages Twitter ads (among many other tasks) and asked her our plans in light of what's been going on with the platform.

She was completely unaware of what's been going on at Twitter in recent months 🤯. It's a US thing to her so she didn't really pay attention. I'm sending her some links.

Lesson: Don't assume everyone is equally aware of what's going on.

#IDMastodon #virology These observations suggest that BA.2.86 is more closely related to sequences from Southern Africa than other regions & so may have evolved there, and that evolution led to escape from #neutralizingantibodies similar in scale to recently circulating strains of #SARSCoV2.
medrxiv.org/content/10.1101/20

"One group was not strongly represented in the streets of Chicago: African Americans. They knew firsthand how well the city police deserved their reputation for brutality. When Daley spoke of the police adopting a “shoot to kill” approach to disorder, their experience taught that he was not kidding."

nybooks.com/articles/2023/09/2

@medrxivpreprint
BA.2.86 showed extensive escape both relative to ancestral virus in sera from pre-Omicron vaccinated individuals and relative to Omicron BA.1 in sera from Omicron BA.1 infected individuals.
medrxiv.org/content/10.1101/20

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"Journalism’s crisis began many years ago, but in her new book, When the News Broke, Heather Hendershot identifies a specific moment when broad public regard for the news media gave way to the widespread belief that they could not be trusted. This was in August 1968, during the infamous Democratic National Convention in Chicago"

nybooks.com/articles/2023/09/2

Her work paved the way for blockbuster obesity drugs. Now, she’s fighting for recognition

Svetlana Mojsov helped discover the hormone GLP-1. Why has she been excluded from its history?

science.org/content/article/he

Elon Musk turning off Starlink to prevent an attack by Ukrainians defending themselves from Russian state aggression is as clear and devastating an indictment of the ancap dream of a stateless but fully-privatized world as I could have ever imagined.

"Antiretroviral therapy regimens containing two active drugs rather than the traditional three are efficacious in treating HIV, but are not suitable for people with HIV and hepatitis B co-infection."

Here's what you should know about these regimens
bmj.com/content/382/bmj-2022-0

'We’re speaking out—despite pressure from the WVU administration to remain silent—because we’re impelled by our responsibility as employees and stewards of this public university to safeguard its integrity and its future.'

bostonreview.net/articles/an-o

“Esse cenário começou a ser previsto em 2014/15 ou 2016. No tempo da crise, cerca de metade dos professores contratados que estavam na escola foram embora. Até foram aconselhados a emigrar porque não havia lugar para eles. O efeito nefasto é que as universidades e as Escolas Superiores de Educação começaram a ficar sem candidatos e a fechar os cursos."

publico.pt/2023/09/07/sociedad

PhD-position in cancer biology

University of Bergen

Come join us At The Department of Biomedicine, University of Bergen. A second full-time PhD-position in Cancer Biology is now available!

See the full job description on jobRxiv: jobrxiv.org/job/university-of-

#ScienceJobs #hiring #research
Bergen #Norway #PhDStudent
jobrxiv.org/job/university-of-

@Kaetchi The initial hypothesis was that the thymus was exerting an endocrine function on gonad development:

"In view of our results, it seems plausible to propose that the thymus has the newly described function of controlling the reproductive faculty in the female mouse."

science.org/doi/abs/10.1126/sc

"Although marketed CAR-T therapies have shown transformative efficacy for certain blood cancers, widespread adoption, as well as applicability to solid tumours and autoimmune indications, have been limited by safety, efficacy and operational hurdles. These hurdles include high rates of adverse events such as cytokine release syndrome (CRS), inability to overcome the immunosuppressive microenvironment typically found in solid tumours, and antigen escape and cell exhaustion that reduce durability."

nature.com/articles/d41573-023

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