Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Most recent studies support the hypothesis that T cells worsen disease, but new research from Su et al.4 reported in this issue of Nature Immunology instead describes brain-infiltrating CD8+ T cells as protectors, not perpetrators, of #Alzheimer’s disease pathology."
#Immunology #Neuroimmunology
Thiago Carvalho
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'In addition to the complications that can occur during the acute phase of a Covid infection, there appears to be an increased risk of heart attacks, strokes and other problems up to a year after an infection. Experts are now trying to understand why.'
https://www.nytimes.com/2023/09/07/well/live/covids-heart-health.html
Thiago Carvalho
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'Mads Krogsgaard Thomsen, chief executive of the Novo Nordisk Foundation, which has the majority of voting rights in the company, described executives asking: “Why would we do such a trial with a high risk of maybe not showing anything? Maybe it’s just the anti-diabetic effect that is responsible for the benefits we’ve seen in diabetes. What if we don’t see anything in obesity, and the trial costs hundreds of millions of dollars?”
https://www.ft.com/content/d951de90-11cc-478b-8592-8312ab9204c7
Thiago Carvalho
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I've been comparing social media platforms for effictiveness at getting out a PhD advert. Comparing reposts not a like-for-like as TwiX and LinkedIn both use likes to populate your feed. On this basis, LinkedIn clear winner, X clear loser. LinkedIn stripped out links though, grr!
Thiago Carvalho
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New blogpost, inspired, as usual, by irritation.
http://deevybee.blogspot.com/2023/09/polyunsaturated-fatty-acids-and.html
I sometimes think the research literature is so mired by questionable research practices that there is really no hope.
#integrity #p-hacking #PublicationBias #QRPs #neurodevelopment
Thiago Carvalho
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Thiago Carvalho
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Spare you the click:
3 post-doc vacancies to join the Steventon Lab at the Dept. of Genetics in Cambridge, UK, on:
1. peripheral nerve regeneration;
2. zebrafish imaging;
3. bioengineering.
https://www.gen.cam.ac.uk/join-us/current-vacancies
Thiago Carvalho
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"Man lives consciously for himself, but is an unconscious instrument in the attainment of the historic, universal, aims of humanity."
War and Peace
Lev Nikolayevich Tolstoy was born #OTD in 1828. He is best known for his two longest works, War and Peace & Anna Karenina, which are commonly regarded as among the finest novels ever written. War and Peace in particular seems virtually to define this form for many readers and critics.
Leo Tolstoy at PG:
https://www.gutenberg.org/ebooks/author/136
Thiago Carvalho
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Cool new work lead by John H Wen:
One-shot entorhinal maps enable flexible navigation in novel environments
https://www.biorxiv.org/content/10.1101/2023.09.07.556744v1
Thiago Carvalho
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Typography: It Matters!
#typography #type #font #fonts #humor #humour #funny #writingcommunity #books #writing
"The importance of conformational ensembles to IDR function, coupled to the inherent sensitivity of IDRs to their physicochemical environment, gives rise to the possibility of IDRs acting as molecular sensors of their surrounding physicochemical environment"
https://www.sciencedirect.com/science/article/pii/S0968000423002049#s0005
Thiago Carvalho
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'In some cases, GWAS results have highlighted previously underappreciated mechanisms contributing to pathogenesis. For example, genetic variants associated with AD risk are enriched in genes and enhancers (regions in the genome that control gene expression) acting in myeloid cells, likely microglia. This indicated the important role of innate immune cells in AD. Therefore, the enrichment of risk variants in specific biological pathways can deepen our mechanistic understanding of neurodegenerative diseases and may even point to new therapeutic targets.'
Thiago Carvalho
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'Desde muy joven, Saura mostró su interés por diferentes disciplinas artísticas. La fotografía, la pintura y la música formaban parte del calor familiar. Pero la pasión por el cine nació en la calle, cuando en el Madrid pobre y apaleado de la posguerra el pequeño se escapaba a las sesiones de los cines de barrio cercanos a su casa familiar de la avenida de Menéndez Pelayo para ver una y otra vez la versión de los años treinta de El prisionero de Zenda.'
https://elpais.com/eps/2023-09-06/las-memorias-visuales-de-carlos-saura.html
You go through a lot of interns...
'Until recently, the only reliable way to determine the age of a polar bear has been to extract a premolar and inspect its growth rings. “No researcher wants to do it,” Dr. Woodruff said'
https://www.nytimes.com/2023/08/10/science/wildlife-aging-epigenetic-clocks.html
"Multivalent antigen display is strongly associated with higher antibody titers and therefore likely has a direct influence on the interaction with B cells. Yet, mechanistic studies in vivo of how antigen valency affects the B cell response are very limited."
#Immunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00367-9
"New York is home to six species of Chiroptera that overwinter in the state; the animals cope with the cold by hibernating, usually underground, in caves or abandoned mine shafts. Dangling from the ceiling by their toes, the bats descend into a state of torpor so complete it resembles suspended animation. Because they don’t move, hibernating bats are easy to census."
https://www.nybooks.com/articles/2023/09/21/spored-to-death-blight-fungi-and-the-coming-pandemic/
Closing a loop: The entire modern field of regulatory T cells emerged from the ashes of the suppressor T cell field because of experiments showing destruction of the reproductive system following neonatal thymectomy.
"We found that Treg depletion induces severe autoimmune orchitis and epididymitis, manifested by an exacerbated immune cell infiltration [CD4 T cells, monocytes, and mononuclear phagocytes (MPs)] and the development of antisperm antibodies (ASA)."
In case you missed it: Matthias Tschöp told me the story of the science behind the popular new class of anti-obesity drugs.
Listen to "Obesity is a Brain Disease" 🎧 👇
Thiago Carvalho
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'Under the terms of the deal, the United Kingdom will pay in €2.6 billion per year to be an ‘associate’ member of Horizon Europe for the rest of the scheme’s current term, set to end in 2027.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
