Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Using an inbred line from a natural population with high diapause plasticity, we demonstrate that diapause is determined epigenetically: only a subset of genetically identical individuals enter diapause and this diapause plasticity is epigenetically transmitted for at least three generations'
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010906
Thiago Carvalho
boosted
The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity https://www.biorxiv.org/content/10.1101/2023.09.23.559132v1?med=mas
Thiago Carvalho
boosted
#BBCNews - What you need to know about #Covid as new #variant rises
https://www.bbc.co.uk/news/health-66848549
Thiago Carvalho
boosted
Sex-specific differences in DNA methylation and gene expression in late-gestation mouse placentas https://www.biorxiv.org/content/10.1101/2023.09.23.559106v1?med=mas
Thiago Carvalho
boosted
Los dinosaurios eran endotermos como las aves actuales
Un trabajo internacional publicado en Nature utiliza por primera vez marcadores metabólicos de especies animales actuales y extintas. Sus altas tasas metabólicas sugieren que los dinosaurios eran endotermos como las aves actuales y permite desechar la hipótesis de que la ectotermia pudo estar detrás de su extinción.
Los dinosaurios y los pterosaurios tenían tasas metabólicas altas, lo que sugiere que eran endotermos –capaces de autorregular su temperatura corporal–, según concluye una investigación internacional publicada en Nature, liderada por la Universidad de Yale y en la que participa la Universidad Complutense de Madrid (UCM).
Este trabajo demuestra que los dinosaurios eran endotermos reales, rechazando ideas anteriores como que tenían una condición intermedia –mesotermia– entre los ectotermos y los endotermos o que podían mantener su temperatura corporal constante gracias a los grandes tamaños corporales, puesto que hay dinosaurios pequeños con altas tasas metabólicas.
En esta investigación se utiliza por primera vez un índice que permite evaluar directamente las capacidades metabólicas de los amniotas – mamíferos, aves, reptiles y grupos extintos como los dinosaurios o los pterosaurios–, tanto actuales como extintos, ya que utiliza marcadores metabólicos que se pueden encontrar fosilizados.
La producción de calor en endotermos se debe al metabolismo, que quema grasas y azúcares. En este proceso, se libera energía (calor) pero también otros productos.
Algunas de las moléculas que se producen pueden fosilizar, y esto está abriendo un nuevo campo en la paleontología, en la que geoquímicos y geoquímicas como Jasmina pueden obtener información de los tejidos originales. En este caso, se miden las señales que dejan molecularmente las altas tasas de metabolismo.
Lee la entrada completa en el blog https://lasendadeapolo.es/2022/06/14/los-dinosaurios-eran-endotermos-como-las-aves-actuales/
'Hopper once said, “There is a certain fear and anxiety and a great visual interest in the things that one sees coming into a great city.” Edward Hopper, “Approaching a City,” 1946 (Phillips Collection).
https://www.villagevoice.com/waiting-for-the-nighthawks-edward-hopper-and-the-denizens-of-new-york/
“La lógica o la ética pierden frente a la respuesta inmediata de los iguales. Ellos, que han crecido subiendo su vida a las redes, ni siquiera entienden lo que es su intimidad... no son nativos digitales, sino huérfanos digitales, los adultos de su entorno no han podido enseñarles a usar una tecnología que ellos tampoco dominan”.
“Finding dinosaurs in Alaska challenges everything we think we know about dinosaurs,” Fiorillo told me. “They’re described as warm-climate, swamp-going things. It’s clear they were way more adaptable than I think we appreciate.”
https://www.theatlantic.com/science/archive/2023/09/alaska-yukon-river-dinosaur-footprints/675429/
Thiago Carvalho
boosted
'This past May Brazilian police officers and officials from the Ministry of Labor rescued a sixty-three-year-old woman from the private home where she had worked, without pay, benefits, or vacation time, for forty-seven years.'
https://www.nybooks.com/online/2023/09/17/the-base-of-the-labor-pyramid/
'The presence of arsenic is not uncommon in antique artifacts. The element is prevalently found in green pigments that were once used to dye clothing, book covers and even artificial flowers, according to Ms. Ritchie. (In the Victorian era, she said, people even ate small amounts of the toxin, hoping to make their skin appear pale.)'
HT @mucida
https://www.nytimes.com/2023/09/23/science/museums-taxidermy-arsenic.html
'Temperature-sensitive (TS) alleles create tunable thermoswitches to deplete essential cellular activities and are used to dissect gene function. In their recent study, Link and colleagues (Schramm et al 2023) use a CRISPR-based approach to systematically create TS alleles across essential genes in E. coli.'
Thiago Carvalho
boosted
'Here, we have shown that IgA B cell receptor (BCR) is required for B cell fitness during the germinal center (GC) reaction in Peyer’s patches (PPs) and for generation of gut-homing plasma cells (PCs).'
#Immunology #MucosalImmunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00374-6
'São já 43% do total
Em apenas três anos, o peso dos professores do ensino superior em situação precária subiu de 39% para 43%. É o que mostra a evolução dos docentes nesta condição entre 2018/2019 e 2021/2022, o último ano com estes dados divulgados pela Direcção-Geral de Estatísticas da Educação e Ciência'
Thiago Carvalho
boosted
Checkpoint inhibitors beyond cancer: targets for restoring CD8 T cell function in people living with HIV.
"Our results demonstrated a marked and significant increase in TIGIT CD8+ T-cells, particularly within the central memory compartment, not ameliorated by long-term ART."
Thiago Carvalho
boosted
'For nearly a year, the painter — known for edgy images appropriated from art history and popular culture, as well as juxtapositions of voluptuous nudes and ham sandwiches — has attempted to defy conventional thinking about generative artificial intelligence by testing an A.I. program’s capacity to become a sophisticated creator of art.'
https://www.nytimes.com/interactive/2023/09/22/arts/design/david-salle-ai.html
Thiago Carvalho
boosted
'We found that Streptococcus pneumoniae, group B Streptococcus, and neonatal meningitis Escherichia coli commonly exploit a unique vesicle fusion mechanism to hitchhike on transferrin receptor (TfR) transcytosis to cross the BBB'
Thiago Carvalho
boosted
Can probiotics protect corals from problems like bleaching?
Lab experiments suggest that a dose of carefully selected microbes may boost the health of these reef-building creatures and their symbiotic algae
Marine microbiologist Raquel Peixoto explains, via @KnowableMag
🪸 Read the Q&A: https://arevie.ws/PeixotoQA
🪸 Read “Coral Probiotics: Premise, Promise, Prospects,” co-authored by Peixoto, in the Annual Review of Animal Biosciences https://arevie.ws/PeixotoReview
Thiago Carvalho
boosted
Discovery of #histidine methylation as a new post-#translational modification of #histone proteins.
https://phys.org/news/2023-09-discovery-histidine-methylation-post-translational-modification.html
'Thus, αCTLA-4 blockade in mesenchymal-like glioblastoma promotes a CD4+T cell-microglia circuit wherein IFNγ triggers microglia activation and phagocytosis and microglia in turn act as antigen-presenting cells fueling the CD4+ T cell response.'
https://www.cell.com/immunity/fulltext/S1074-7613(23)00328-X
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
