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Obituary for Jeffrey Pollard at Nature Cancer

"His landmark discovery in 2001 on the tumor-promoting role of macrophages in breast cancer propelled the cancer research field into studying the pro-tumoral roles of the immune compartment."

nature.com/articles/s43018-023

'Richard Estes, ‘M Train on Route to Manhattan Approaches the Williamsburg Bridge’ (1995) © Richard Estes, courtesy Louis K Meisel Gallery'

ft.com/content/0f7b0a94-029b-4

'Discussions now taking place at the World Health Organization seek to reach consensus on a new pandemic agreement. The intention is to learn from mistakes made during Covid-19 to better prepare for the future. Unfortunately, a key intellectual property problem remains unaddressed, threatening to limit the scope of what the agreement can achieve in assuring timely and equitable access to pandemic countermeasures.'

ft.com/content/c76d6f5a-0d82-4

'This paper reports the results of mutant screens of carried out in 1988 at Caltech and several years subsequently at Monash University that focused on flower and how they helped build a foundation for our understanding of this process'

academic.oup.com/genetics/arti

"Although RBP-J is recognized as a key inhibitor of TNF-mediated osteoclastogenesis, the precise mechanisms that restrain TNF-induced differentiation of macrophages into osteoclasts are not fully elucidated. In this study, we identified that the Notch ligand Jagged1 is a previously unrecognized RBP-J target."

journals.aai.org/jimmunol/arti

This week is National Inclusion Week (25th Sep - 2nd Oct), the theme for this year is 'Take Action, Make Impact.'

We have a number of resources to support diversity and inclusion within your organisation.

View EEDI resources: lnkd.in/eGxhhK_U

Watch co-production webinar: lnkd.in/eb94ipiN

#Inclusion #Diversity #NationalInclusionWeek #Research

Dear microbial bioinformaticians. I have developed a cool genomes-to-report pipeline which I have named "assemblycomparator2" for prokaryotic genomes. (I think of it as a potential successor to Nullarbor.)

I'm thinking about finishing it up with an easy-to-install conda package but I need some help to get started. Is anyone interested in testing my software and giving me some feedback on how to develop this further?

github.com/cmkobel/assemblycom

#bioinformatics #prokaryotes #kegg #phylogenetics

'Records that might have thrown a crucial light on key decisions taken by the UK government were mysteriously destroyed during the 1980s and 1990s when legal developments in other countries seem to have raised fears in Whitehall that officials might be found liable.'

ft.com/content/cd374a7f-69c3-4

Job at EMBL-EBI

"As Human Genomics Team Leader, you will be responsible for a multidisciplinary team of approximately 20 individuals, which includes software developers, bioinformaticians and data curators."

embl.org/jobs/position/EBI0217

'Unlike bread-and-butter issues like wages, benefits and the terms and conditions of employment — topics over which management, according to labor law, must negotiate “in good faith” — technology, like business strategy, constitutes managerial prerogative. This means that the use of technology, such as artificial intelligence, exists in a bargaining gray area. If workers bring it up, employers can either open a negotiation or reply with a simple “No, thanks.” But the W.G.A. deal put A.I. squarely on the table.'

nytimes.com/2023/09/29/opinion

Metz, with David del Alamo on the way to Luxembourg to kick off a new training module tomorrow.

🧪Anthony Domma’s paper from his PhD dissertation work in my laboratory is live at J Virol. Surprisingly, human cytomegalovirus (CMV) relies on PI3K/AKT being shut off via a well studied cell intrinsic mechanism (CMV rewires so much about mTOR!). The virus needs AKT “off” and FoxO transcription factors in the nucleus (AKT causes FoxO nuclear export) to efficiently replicate. #Virology #AKT #CMV #HCMV #LoveVirology journals.asm.org/doi/10.1128/j

"But a series of strikes in higher education has swept across the United States and other countries, amid a reckoning over low pay and poor working conditions. The burgeoning biotech industry now offers US salaries that average $94,000, outstripping early-career academic positions by tens of thousands of dollars."

nature.com/articles/d41586-023

The strain on scientific publishing 📄:

The publishing sector has a problem. Scientists are overwhelmed, editors are overworked, special issue invitations are constant, research paper mills, article retractions, journal delistings… JUST WHAT IS GOING ON!?

Myself, @pablo, @Paolo, and @Dan have spent the last few months investigating just that.
arxiv.org/abs/2309.15884

A thread🧵1/n

#AcademicChatter #PublishOrPerish #Elsevier #Springer #MDPI #Wiley #Frontiers #PhDAdvice #PhDChat #SciComm

“One man’s election misinformation is another man’s free speech” - Elon Musk

The other man happens to be Vladimir Putin.

theinformation.com/articles/mu

Metz, with David del Alamo on the way to Luxembourg to kick off a new training module tomorrow.

"Grand Cosmic Fireworks. Winner, Skyscapes. Sprites are an extremely rare phenomenon of atmospheric luminescence that appear like fireworks. An took this photograph from the highest ridge of the Himalaya mountains."

theatlantic.com/photo/2023/09/

"The Cell Biology Division of the MRC Laboratory of Molecular Biology (LMB), a research institute within UK Research and Innovation (UKRI), invites applications for a tenure-track Group Leader position."

nature.com/naturecareers/job/1

The GOP is out to undo the most positive contribution of any republican president in my lifetime.

"In 2003, nearly 30 million Africans had AIDS, including 3 million under the age of 15. In some countries, more than one-third of the adult population carried the disease. More than 4 million required immediate drug treatment, yet only 50,000 AIDS victims were receiving the medicine they needed."

theatlantic.com/ideas/archive/

'This paper reports the results of mutant screens of carried out in 1988 at Caltech and several years subsequently at Monash University that focused on flower and how they helped build a foundation for our understanding of this process'

academic.oup.com/genetics/arti

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