Thiago Carvalho @cyrilpedia@social.cleverlibre.org

[#VeilleESR #WRanking] L'Université d'Utrecht annonce son retrait du THE Ranking, souhaitant favoriser la collaboration plutôt que la compétition.

Elle est classée 66e mondiale dans ce classement.

https://www.timeshighereducation.com/world-university-rankings/utrecht-university

'Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors.'

https://www.nejm.org/doi/full/10.1056/NEJMoa2206916?query=featured_home

'The latest vaccine will now be rolled out on a wide scale to the countries in sub-Saharan Africa where children are at the greatest risk from malaria. Oxford university has a manufacturing agreement with the Serum Institute of India'
#Malaria #Vaccine #Immunology
https://www.ft.com/content/4a54139e-7da7-48d2-bba9-487bf88ed811

Evolution strikes again

"One of the most uncommon hinges of vertebrate Ig is that exclusively found in Antarctic fishes: IgM H chain has a remarkably long hinge region, ranging from 14 to 22 amino acid residues, highly polymorphic, and rich in prolines and glycines (Coscia et al, 2000; Coscia et al, 2011; Coscia et al, 2012). Given these peculiar features, the hinge region has been suggested to provide the cold Ig molecule with higher flexibility to exert its function at very low kinetic energy in the Antarctic environment."
#Preprint #Immunology

https://www.biorxiv.org/content/10.1101/2023.10.04.560855v1.full.pdf

Gene therapy targeting regulatory elements to promote fetal hemoglobin expression in sickle cell disease.
My latest Clinical Pipeline column at Nature Medicine

#DrugDevelopment #DrugDiscovery #Crispr #SickleCell

https://www.nature.com/articles/d41591-023-00088-6

On vaccines in today's Economist, worth a read https://www.economist.com/leaders/2023/10/05/in-an-ugly-world-vaccines-are-a-beautiful-gift-worth-honouring

The platform formerly known as Twitter has now removed headlines from article links. Because what people really want to do is waste time clicking a picture while completely uncertain about what’s behind it.

The most American story of all time. Grocery store and potato chip CEOs are worried about the impact of people taking recently FDA approved weight loss drugs on their profits.

A story where there’s no one to root for and whoever loses, greed wins.

Postdoctoral researcher position at Institut Pasteur in Paris

Institut Pasteur in Paris

Join us for a #postdoc at #institutpasteur. Learn about #immunogens and #herpesviruses, while having a ball and living in #Paris.

See the full job description on jobRxiv: https://jobrxiv.org/job/institut-pasteur-in-paris-27778-postdoctoral-researcher-position-at-institut-...
https://jobrxiv.org/job/institut-pasteur-in-paris-27778-postdoctoral-researcher-position-at-institut-pasteur-in-paris/?feed_id=60989

New article! Read Proof of concept for a single-dose Group B Streptococcus vaccine based on capsular polysaccharide conjugated to Qβ virus-like particles https://www.nature.com/articles/s41541-023-00744-5?utm_source=dlvr.it&utm_medium=mastodon in npj Vaccines

Tools

"CompRELEASE enables complex control of protein secretion and enhances the potential of synthetic protein circuits for therapeutic applications, while minimizing the overall genetic payload."

#Preprint

https://www.biorxiv.org/content/10.1101/2023.10.04.560774v1

Boar candlestick holder by @hunchbacksociety

#Ceramics #stoneware #pottery #Handmade #Art #stoneware #artgallery #artmastodon

https://madalenaparreira.com/Hunchbacksociety

In interviews, Katalin Karikó remarkably expresses no bitterness about her experiences. Just a clear focus on the goal of using mRNA to treat human disease. https://www.pnas.org/doi/10.1073/pnas.2119757118 #Nobel #science

'The snub was about more than just gender, according to Ms. Moss. “It’s easy to say she (Lise Meitner) didn’t get it because she was a woman,” Ms. Moss said. “One doesn’t think a woman is going to make noise about things.” Ms. Moss also believes Meitner’s heritage was at play: “This is a case where it was because she was a Jew.”

https://www.nytimes.com/2023/10/02/science/lise-meitner-fission-nobel.html

"Perhaps crypto was a legit fountain of wealth and success – perhaps it was moneyball for money, in which a new gang of smart rationalists were outfoxing traditional investors. Which made Sam Bankman-Fried, the lord and saviour of these renegades, a perfect Michael Lewis character."

https://www.theguardian.com/books/2023/oct/03/michael-lewis-sam-bankman-fried-crypto-going-infinite

"His book is a masterful demonstration of the great potential of the new military history that has emerged over recent decades as scholars, distancing themselves from an older generation mainly interested in chaps and maps, have begun to pay more attention to the social, economic, and political aspects of war."

https://www.nybooks.com/articles/2023/10/19/is-prussian-militarism-a-myth-iron-and-blood/