Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Preliminary results from the Denver Basic Income Project that's providing cash to hundreds of unhoused people for one year, using the first 6 months of data:
• NO ONE receiving $1,000/mo still sleeping outside
• Full-time employment increased
• Fewer visits to the ER
• Fewer nights spent in jail
• Reduced use of social and public services
Read the full report: https://drive.google.com/file/d/1gqtOfZG2sSanWgUdzn-lx-pwSXZKabj-/view?pli=1
Thiago Carvalho
boosted
Great interview in Science with my friend, the artist Rob Kesseler. I still remember a great exchange with a student at Instituto Gulbenkian de Ciencia who watched how Rob created art starting from images collected in collaboration with labs and let out an exasperated "You cant do that!".
Rob calmly replied "I can, I'm an artist".
https://www.science.org/content/blog-post/no-one-ever-asked-monet-if-they-were-false-colors
Thiago Carvalho
boosted
"La vacuna comenzó a inocularse en abril en Ghana. Y hay 18 países africanos que ya están solicitando dosis a través de GAVI. La OMS espera que con la mayor producción que comenzará a mediados del año que viene, más Estados se sumen a esta lista."
Thiago Carvalho
boosted
'If Sunak had pissed about any longer, the Netflix doc about the decision could actually have come out while he was still droning on about not having decided it. This would have ripped a tear in the events-to-content continuum, reversing the natural direction of travel, and effectively ceding control of the UK to Netflix CEO Ted Sarandos. Then again, maybe it would be an upgrade. At this rate, the best hope for the country might be for Ryan Reynolds and the other one to buy us and use us as a content farm.'
Thiago Carvalho
boosted
Thiago Carvalho
boosted
On this day in 1930: June Almeida born, electron microscopy pioneer, took first image of human coronavirus, rubella virus and uncovered hepatitis B virus s
Gene therapy targeting regulatory elements to promote fetal hemoglobin expression in sickle cell disease.
My latest Clinical Pipeline column at Nature Medicine
Thiago Carvalho
boosted
Shocking story about mRNA pioneer/Nobel winner Katalin Karikó, whose early advisor at Temple tried to have her deported & derailed her career because she dared to look for a better-paying job.
Later, UPenn demoted her, then forced her out, because her research wasn't bringing in enough funding. #NobelPrize #science [HT Paul Novosad]
Thiago Carvalho
boosted
#^Pomological
This Aeon Video exclusive explores the history and legacy of a beautiful project to record thousands of new fruit varieties
- by Aeon Video
Watch at Aeon
This Aeon Video exclusive explores the history and legacy of a beautiful project to record thousands of new fruit varieties
- by Aeon Video
Watch at Aeon
Boar candlestick holder by @hunchbacksociety
#Ceramics #stoneware #pottery #Handmade #Art #stoneware #artgallery #artmastodon
Thiago Carvalho
boosted
#IDMastododon #Viralimmunology #Immunology #Drugdevelopment The activation of #Bcells upon the binding of antigens to the B cell receptor (BCR) is important for vaccine-based #antibody production. B cells are more strongly activated by membrane-bound than by soluble antigens 🧵
Thiago Carvalho
boosted
Single-cell impedance cytometry of anticancer drug-treated tumor cells exhibiting mitotic arrest state to apoptosis using low-cost silver-PDMS microelectrodes https://www.biorxiv.org/content/10.1101/2023.10.04.560818v1?med=mas
Evolution strikes again
"One of the most uncommon hinges of vertebrate Ig is that exclusively found in Antarctic fishes: IgM H chain has a remarkably long hinge region, ranging from 14 to 22 amino acid residues, highly polymorphic, and rich in prolines and glycines (Coscia et al, 2000; Coscia et al, 2011; Coscia et al, 2012). Given these peculiar features, the hinge region has been suggested to provide the cold Ig molecule with higher flexibility to exert its function at very low kinetic energy in the Antarctic environment."
#Preprint #Immunology
https://www.biorxiv.org/content/10.1101/2023.10.04.560855v1.full.pdf
Thiago Carvalho
boosted
STAT+: Failed biotech gives a rare peek inside the tough breaks -- and tough choices -- that led to its demise
'RNA’s fleeting nature isn’t a big problem for a vaccine: it needs to encode proteins only for a short time to trigger an immune response. But for most therapeutic applications, it would be much better to have RNA that could stick around for longer.'
Thiago Carvalho
boosted
Ph.D. position in Plant Molecular Biology
University of Lausanne
Ph.D. position in Plant Molecular Biology - mechanisms of root system development and physiology
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-lausanne-27778-ph-d-position-in-plant-molecular-biology/?feed_id=60832
#ScienceJobs #hiring #research
Lausanne #Switzerland #PhDStudent
https://jobrxiv.org/job/university-of-lausanne-27778-ph-d-position-in-plant-molecular-biology/?feed_id=60832
Bernd has been pushing this point for a while, and I think he is right. Self correction is an important part of the scientific process and journals, funders, and institutions need to do more to encourage it.
'What can journals do to support both self-correction by authors and by the community? We have discussed this matter for a decade at EMBO Press, culminating in a workshop that recommended to make an explicit distinction between an author initiated- and an externally initiated- or even forced retraction. We use the term “withdrawal” for the former and reserve “retraction” for the latter.'
#scientificpublication #ResearchIntegrity
@emboreports
'In a bid to stem the resurgence of sexually transmitted infections, the Centers for Disease Control and Prevention plans to recommend doxycycline, a widely used antibiotic, for use after an unprotected sexual encounter.'
https://www.nytimes.com/2023/10/03/health/doxycycline-syphilis-gonorrhea-chlamydia.html
'Disinformation campaigns — some armed with AI-generated deepfakes — are likely to be rampant in the coming months, says Ulrike Klinger, who studies political communication at the European University Viadrina in Frankfurt (Oder), Germany. “And we cannot monitor them because we don’t have access to data.”
Tools
"CompRELEASE enables complex control of protein secretion and enhances the potential of synthetic protein circuits for therapeutic applications, while minimizing the overall genetic payload."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
