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The effects of the CTLA4 deletion were not very surprising, what's fascinating here is how it compares to the double mutants (PD1/CTLA4).

"CTLA4 disrupted CART19 cells display prolonged surface CAR expression, increased proliferation, and enhanced CART19 effector function supported by unopposed CD28 co-stimulation, which is lost in CART19 cells deficient for both PD-1 and CTLA4"

cell.com/immunity/fulltext/S10

@alexblock Serotonin is known to play a role in the regulation of the sleep cycle, so that's definitely possible.

"Future outbreaks are inevitable. How do we ensure that research systems are in place and work when we next need them? In 2022, when the global outbreak of mpox emerged, clinical trialists had new tools for rapid rollout of trials; however, the system failed another stress test. In this Viewpoint, we highlight areas for improving implementation of future epidemic clinical trials"

jamanetwork.com/journals/jama-

"In this review, we discuss key advances that highlight mechanisms used by T cell subsets to populate the epidermis and dermis, maintain skin homeostasis, and regulate wound repair."

journals.aai.org/jimmunol/arti

'Before it released the A.I. chatbot ChatGPT last year, the San Francisco start-up OpenAI added digital guardrails meant to prevent its system from doing things like generating hate speech and disinformation. Google did something similar with its Bard chatbot.
Now a paper from researchers at Princeton, Virginia Tech, Stanford and IBM says those guardrails aren’t as sturdy as A.I. developers seem to believe.'

nytimes.com/2023/10/19/technol

What might #OpenScience look like in the future?

By examining past initiatives, this #PLOSBiology Essay offers recommendations to funders, institutions, journals, and stakeholders to create an environment conducive to open science.

plos.io/3QnfyhQ

"Oito funcionários doutorados da Fundação para a Ciência e a Tecnologia (FCT) assinam uma carta enviada a esta instituição em que reclamam salários iguais aos trabalhadores com contratos a prazo e que têm as mesmas funções. Em causa está a “discriminação subjectiva” na principal instituição que financia a ciência em Portugal: as diferenças salariais rondam, no mínimo, cerca de 500 euros, reclamam."

publico.pt/2023/10/20/ciencia/

On
nitter.cz/search?q=%23EurStats
, explore our dashboard & discover all the info you need on ERC-funded projects. 📊🔍
The platform allows you to filter projects by funding scheme, country, year, panel, & export results and graphs.
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erc.europa.eu/projects-statist
nitter.cz/search?q=%23datavisu
nitter.cz/search?q=%23research

🐦🔗: nitter.cz/ERC_Research/status/

[2023-10-20 07:00 UTC]

📣 Calling on Africa-based researchers. We need your input!

Voice your opinion in our survey: "Awareness and perception of #preprints amongst African-based researchers" to help direct efforts towards expanding the adoption of preprints in the African region.

asapbio.org/perceptions-of-pre

Molecular #phylogeny of #Formica #ants!

Parasitic colony founding is likely to be an intermediary step between free-living hosts and slave-maker parasites

ncbi.nlm.nih.gov/pubmed/295927

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@josemanuel A more predatory aspect in mining genetic/population data in the developing world & then enmeshing it in patents & other forms of IP protection. In which case there is no sharing at all, it's just strip mining genetic resources.

@josemanuel What you're missing is the focus of the piece: the lack of data sharing and credit for the communities where the data was mined.

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