Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Tsuba, oil & goldleaf

#Art #ArtGallery #artmastodon

https://madalenaparreira.com

"When applied to a KRASG12D small molecule inhibitor I observe a wide degree of intracellular levels of the drug, and that proteomic responses largely stratify based on the concentration of drug within each single cell"

#Preprint #Pharmacology

https://www.biorxiv.org/content/10.1101/2023.11.18.567669v1

"I strongly endorse this piece by @gregggonsalves at The Nation. I've been hitting on some of the same themes here on the blog and elsewhere - that the FDA is becoming too lenient in drug approvals, that advocacy groups are abetting this too often, and that patients are not actually served by allowing them to take drugs that don't work."

https://www.science.org/content/blog-post/getting-accelerated-approval-wrong

"Built in 2000, this seed bank is one of as many as 1,700 worldwide, otherwise known as ‘“doomsday vaults”: facilities intended to safeguard humanity in the event of civilisation’s collapse. It isn’t just about seeds – researchers are preserving everything from DNA to data, and even faeces. Should it all go wrong, these Noah’s Arks could provide the blueprints for our recovery."

https://www.theguardian.com/environment/2023/nov/19/the-doomsday-vaults-storing-seeds-data-and-dna-to-protect-our-future

"So far, much of the news coverage of Ozempic and similar drugs has focused on whether they work—and what their side effects might be. But the real story will begin when this emergent form of treatment becomes utterly routine, as it almost certainly will. Most people in America, the richest country in the world, are fat. Almost three-quarters of adults older than 20 live with obesity or overweight. And given the popularity of existing weight-loss treatments, we can deduce that most of those people would rather not be fat. The consequences of the Ozempic revolution will be economic and social, as well as medical. The new drugs will transform people’s relationship with eating—and with one another."

https://www.theatlantic.com/ideas/archive/2023/11/ozempic-wegovy-social-revolution-weight-loss/676002/

'Desde luego, la confusión, la incertidumbre e incluso la apatía en medio del caos dan una enorme ventaja a una persona tenaz y decidida, ya sea Napoleón después de la Revolución Francesa o Lenin tras la Revolución Rusa de febrero de 1917. Los dos se hicieron con el poder durante un interregno, que Alexander Herzen denominó “la viuda encinta”: el periodo posterior al derrocamiento de un antiguo régimen y anterior a que nazca su sucesor.'

https://elpais.com/cultura/2023-11-19/napoleon-y-la-teoria-del-gran-hombre-de-la-historia.html

"Inmet thermometers repeatedly registered temperatures above 40C across the centre-west and south-east, with a peak of 43.3C in Corumbá on the border with Bolivia on Wednesday. With temperatures hitting 37.7C and 42.6C, respectively, São Paulo and Rio de Janeiro broke records for the year. In Rio, affectionately nicknamed “Hell de Janeiro” by locals, feels-like temperatures reached a staggering 59.7C on Saturday."

https://www.theguardian.com/global-development/2023/nov/19/brazil-temperatures-extreme-heat-danger-climate-change-inequality

"One of the issues that is certain to be explored is whether the scientists were adequately consulted at key moments, including about the eat out to help out scheme, in which the public were offered a discount on restaurant bills to encourage them to eat out."

https://www.theguardian.com/uk-news/2023/nov/19/scientists-set-to-expose-chaos-and-disagreement-in-uk-government-at-covid-inquiry

News to me:

"Although described mostly in the context of lymphocytes, recent studies by our laboratory showed that IL-2R is expressed in smooth muscle cells."
#Preprint #immunology

https://www.biorxiv.org/content/10.1101/2023.11.03.565571v2