Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"More than 13 million SARS-CoV-2 genome sequences have been submitted to databases, such as Global Initiative on Sharing Avian Influenza Data (GISAID). The assignment of consistent metadata to these genome sequences facilitates data integration, accessibility and the re-use of data for insightful analysis in future studies"
#Covid19 #SARSCoV2

https://www.nature.com/articles/s41587-022-01538-1

In patients with advanced head and neck squamous cell carcinoma.
#Immunotherapy #TumorImmunology #Preprint

"Through a combination of single-cell analyses by mass cytometry (CyTOF), single-cell RNA-sequencing and TCR- sequencing (sc-RNA+TCR-seq), single cell RNA- and protein-sequencing (CITE-Seq), and multiplexed ion beam imaging (MIBI), we examined CD8+ T cells across tissues from patients treated with surgery as standard of care as well as patients treated with perioperative anti-PD-L1 ICB (atezolizumab)"

https://www.biorxiv.org/content/10.1101/2022.11.08.513062v1

"If you are looking to move away from a lecture podium—and we hope that you are— ASCB’s PALM (Promoting Active Learning and Mentoring) program offers an incredible list of resources encompassing biology topics to teaching techniques https://palm.ascb.org/resources/ " https://www.ascb.org/publications-columns/office-hours-with-edcomm/learning-to-teach-the-why-and-the-way/

"These peptides are translated from the same bicistronic transcript and share sequence similarities, suggesting that they encode paralogs. Yet, Sloth1 and Sloth2 are not functionally redundant, and loss of either peptide causes animal lethality, reduced neuronal function, impaired mitochondrial function, and neurodegeneration." https://elifesciences.org/articles/82709

"The book, which is a very personal guide to fiction writing peppered with biography and opinion, contains a handful of strange, and strangely revealing, moments such as these, when his experiences read more like passages from his novels than fact." https://www.theguardian.com/books/2022/nov/06/novelist-as-a-vocation-by-haruki-murakami-review-the-secrets-behind-the-literary-phenomenon

Meanwhile, in the Eastern US:

"Species considered human commensals like squirrels, and raccoons had high seroprevalence, ranging between 62%-71%, and sites with high human use had three times higher seroprevalence than low human-use areas."

https://www.biorxiv.org/content/10.1101/2022.11.04.515237v1.abstract

"Here, we combined pooled CRISPR-Cas9-based functional screening of 5,072 fitness-conferring genes in human HeLa cells with microscopy-based imaging of DNA, the DNA damage response, actin, and microtubules. Analysis of >31 million individual cells identified measurable phenotypes for >90% of gene knockouts, implicating gene targets in specific cellular processes"
https://www.cell.com/cell/fulltext/S0092-8674(22)01359-9

"Grunya Sukhareva published her findings about the children in two German papers — one in 1926, about the boys, and a 1927 paper about the girls — in which she stated that the cases represented a previously unrecognized group of disorders. Today, these case studies read as descriptions of children with autism"

https://www.spectrumnews.org/news/the-new-history-of-autism-part-i/

"On Monday, the universities in the Netherlands opened a hotline for scientists who receive threats. According to the universities, scientists have experienced “too much” online hatred, physical threats, and harassment in recent years. They hope the hotline will make it easy for them to find help."

https://nltimes.nl/2022/11/07/dutch-universities-open-hotline-threatened-scientists-academics