Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"The vaccine, called Qdenga and developed by the pharmaceutical company Takeda, headquartered in Tokyo, is particularly significant because it is the first for people who have not been exposed to dengue. The virus infects up to 400 million people a year. The Indonesian drug regulator approved use of the vaccine without testing for previous exposure in August. Europe’s drug regulator is also considering approving the vaccine without testing."
#Dengue

https://www.nature.com/articles/d41586-022-03546-2

If you can take a 5 minute break, here's Gillian Anderson reading Helen Keller's letter to the New York Symphony Orchestra

https://www.youtube.com/watch?v=CQIWnphdx2Q

"Schools across Uganda will close two weeks before the scheduled end of term after 23 Ebola cases were confirmed among pupils, including eight children who died.

Education Minister Janet Kataha Museveni said on Tuesday that the cabinet had taken the decision to close preschools, primary schools and secondary schools on November 25 because densely packed classrooms were making students highly vulnerable to infection."
#Ebola

https://www.aljazeera.com/news/2022/11/8/uganda-to-close-schools-early-after-eight-children-die-of-ebola

"Within the last few decades, the public health community saw a path toward global eradication of polio, especially with the World Health Organization declaring wild poliovirus eradicated in Africa in 2020. It would have followed #smallpox, which was declared to have been eradicated worldwide in 1980. That didn’t happen, in large part due to the effects of global under-vaccination caused by a combination of mistrust, poor implementation, lack of access in conflict zones, insufficient funding, loss of global momentum, and work suspended because of the #Covid19 pandemic."
#Polio

https://www.statnews.com/2022/11/09/shoe-leather-public-health-efforts-respond-polio-reemergence/?utm_campaign=twitter_organic&utm_medium=social&utm_source=twitter

"The small suggestions of something wrong will amplify and multiply as time goes on, he predicts—in part because the skeleton staff remaining to handle these issues will quickly burn out. “Round-the-clock is detrimental to quality, and we’re already kind of seeing this,” he says."

https://www.technologyreview.com/2022/11/08/1062886/heres-how-a-twitter-engineer-says-it-will-break-in-the-coming-weeks/?fbclid=IwAR0p61EDOWyT4NvVwCMMAFEmQfwhIu-Q5TxEtm2_EkcnVBTgYSRUcM1q7nI

"Many of the earliest lanterns were made in Germany in the workshops of the Nuremberg toy makers. Early allusions to projection devices can be found in Giovanni Fontana (c.1420) and Giovanni della Porta (1589), but the first printed description appears in the second edition of Ars magna lucis et umbrae by Athanasius Kircher, published in 1671. "

https://www.lrb.co.uk/the-paper/v44/n21/chloe-aridjis/at-the-swedenborg

"We postulate the existence of a protective down-regulated state in specific clinical scenarios in humans similar to that observed in anoxia-tolerant vertebrates. Induction of this state suggests new approaches to enhancing coma recovery."

https://www.pnas.org/doi/10.1073/pnas.2120221119

An interesting question from the POV of the coevolution of symbiont genomes:

"One of the unsolved mysteries of kleptoplasty, particularly in animal cells, is how the host is able to maintain algal chloroplasts in a photosynthetically competent state for long periods, after stripping them of their nuclear entourage."
#Evolution #Symbiosis #Genomics

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001857

Word of the day:

"Kleptoplasty, the process by which a host organism sequesters and retains algal chloroplasts, is relatively common in protists"
#chloroplast

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001857

Also a huge problem in the US. We were very lucky to have access to outstanding subsidised daycare at Rockefeller when we were in NY.

"To anyone without children, nursery fees may not feel like an immediate and overwhelming threat to 21st-century feminism. But a brief look at the numbers is sobering. The costs of childcare in the UK today are higher than the majority of other high-income economies. Staggeringly, one analysis reports that the nursery bill for families with a child under two has risen by 44 per cent since the Conservatives have been in power"

https://www.newstatesman.com/quickfire/2022/11/childcare-costs-women-back-to-1950s?utm_medium=Social&utm_source=Twitter#Echobox=1667808633

"We find the preferential expansion of a population of HA-binding atypical memory phenotype B cells in younger adults (22–36 years old) that does not occur to the same extent as in older people (67–86 years old). These atypical memory B cells show evidence of positive selection by the location and burden of somatic hypermutation in younger, but not older, adults, suggesting an impaired GC response in older persons"
#Immunology #Germinal Center #Bcells #influenza

https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01482-6