Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Final call: my #cellbiology lab has a #postdoc #vacancy. If you are into #microscopy #remixing cell biology and figuring out how cells and neurons do stuff, take a look!

https://tinyurl.com/roylePostDocJob

Closing date is TODAY!

#paperoftheday

Amazing work showing that #genetic #disruption of the #kinase module (CDK) of Mediator complex in chimeric #antigen receptor T cell (CAR T) resulted in enhanced effector function and increased #antitumor activity (disruption of CDK module increases core Mediator #chromatin occupancy at #enhancers)

https://www.science.org/doi/10.1126/science.abn5647

Nice piece by @HelenBranswell on #COVID mitigation strategies this festive season. My plans: celebrate but #vaccinate (and boost!); fest but #test (just before gathering); reduce chance of exposure in week leading up to Thanksgiving; #maskup in public places indoors still. Not a big pain for us, not absolutely fool-proof, but where I ended up. And importantly I have the resources to do this. Had COVID in October, RAT-positive for three weeks! I do not want this again.

https://www.statnews.com/2022/11/21/how-infectious-disease-experts-are-responding-to-covid-nearly-three-years-in/?utm_source=STAT+Newsletters&utm_campaign=c5966cffd4-MR_COPY_01&utm_medium=email&utm_term=0_8cab1d7961-c5966cffd4-149665941

My #introduction is overdue. I’m a professor at Penn who studies memory using systems and computational approaches. I’m also writing a book: When it comes to understanding the brain, what are we trying to achieve? What’s our plan to get there? What challenges do we face? #neuroscience #author

Writing has deepened my appreciation for community-based progress. I’m excited to be on this inclusive platform where we can leverage collective intelligence, and work through conceptual blocks together.

The lab of Jonathan Rodenfels at MPI-CBG is looking for a postdoctoral researcher in the Energetics of Biological Systems. The research group pursues interdisciplinary experimental research at the interface of cell & developmental biology, metabolism, biochemistry, and physical bioenergetics. https://www.mpi-cbg.de/join-us/open-positions/job-offer/postdoctoral-researcher-energetics

Hello world, it's time to do an #introduction! I'm a neuroscientist (postdoc) currently based in Göttingen, Germany. I have broad interests in #neuroscience, including sensory coding, neural circuits, and sensorimotor transformations.

So far, I studied how the retina processes natural scenes using a combination of large-scale electrophysiology and computational modeling.

I'll be soon leaving the tidy entryway to the visual system to venture into understanding cortical processing during decision-making.

Very cool paper on ML interpretability and explainability.
I was surprised I hadn't come across it before https://arxiv.org/abs/2012.01805

#machinelearning #ai #explainable #eth

so cool. it looks like diet can drive recovery from flu in this model of grain vs proccessed food https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01509-1#%20

Last chance to apply for a #paleovirology #postdoc position in my group, today and tomorrow!

https://www.nature.com/naturecareers/job/postdoctoral-research-assistant-university-of-oxford-765579

Having a look through the axolotl genome and it seems there are two copies of Brachyury present. Does anybody have examples of this in other species not due to whole are partial genome duplication? #DevBio

Hi it's me - hoping all of my great tweeps are here somewhere

The single best thing written on endemicity & #COVID is by @ariskatzourakis from last January.

"Thinking that endemicity is both mild and inevitable is more than wrong, it is dangerous: it sets humanity up for many more years of disease, including unpredictable waves of outbreaks. It is more productive to consider how bad things could get if we keep giving the virus opportunities to outwit us. Then we might do more to ensure that this does not happen."

@epidemiology

https://www.nature.com/articles/d41586-022-00155-x

Thanks to CZI funding, we will soon have a Research Software Engineer (#RSE) position at the UCL Sainsbury Wellcome Centre to work on #BrainGlobe (https://github.com/brainglobe) and develop #napari plugins.

The post will be based in my RSE team and collaborate with the UCL Centre for Advanced Research Computing.

Happy to chat informally to anyone interested.

Official advert will follow soon. The salary will be UCL Grade 8 (£47k+) for a fixed term of two years in the first instance.

As additional Appendix to my #introduction, I would like to #boost our recent #DrugDiscovery efforts in the field of #CysticFibrosis: we have developed #MultiTarget compounds acting at the same time as #CFTR #Correctors and #Antibacterials or #Antivirals depending on the specific functionalization of the same chemotype.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202200277
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01416