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Hello Mastodon Science. My lab at Yale studies innate immune defense against respiratory viruses. Some of our recent work has focused on viral interference, a phenomenon in which one viral infection can temporarily protect from another. This article discusses the field, and is thought provoking in light of the current resurgence of multiple viruses. science.org/content/article/co

'We previously showed that delaying macrophage recruitment by clodronate liposome (CL) treatment compromises neutrophil resolution and heart regeneration, even when the infiltrating macrophage number was restored within the first-week post injury (Lai et al., 2017). Here, we examined the molecular mechanisms underlying the cardiac repair of regenerative PBS-control hearts vs. non-regenerative CL-treated hearts.'

biorxiv.org/content/10.1101/20

"More importantly, lecanemab might not work very well. From the data released so far, it is unclear what difference it could make to the devastating burden inflicted by Alzheimer’s. Some doctors warn that the benefits of the drug seem so small, patients may not even notice. But others counter that any effect on Alzheimer’s deserves celebration: it proves the disease can be beaten, or at least slowed down. It’s a start, a concrete foundation to build on."

theguardian.com/society/2022/n

#IDMastodon #Eosinophils participate in the critical Th2 arm of immunological control of helminthic infections through Fc-receptor-mediated IgE approximation to worm tegument followed by degranulation. Most labs & literature define eosinophils as ⬆️ when they are bw 0.4-0.5 bil/L
twitter.com/boggildlab/status/ 🧵 by @BoggildLab

#TCells + #Genomics + #Oncology!

Please enjoy this LJI External Seminar from Hongbo Chi, Ph.D., of St. Jude's Research Hospital.

"Functional genomics of T cell metabolism and immuno-oncology:" youtu.be/rTd1gHQuMhg

#Cancer #CenterResearch #Immunology #Immunotherapy #Metabolism #SystemsBiology #ProteinSignaling #CARTCells #TCellMemory

We are pleased to announce the 2023 R. C. Lewontin Early Award competition! These awards provide up to $2,500 USD for first and second year PhD students. Proposals due February 15!
evolutionsociety.org/content/s

I guess I should introduce myself #onhere: I am a postdoc in the Schier Lab at the Biozentrum (Switzerland). I am using #zebrafish to understand the #development of the nervous system. I love developmental biology of classic and non-canonical organisms, microscopy, loud music and comic books. Very much looking forward to meeting other scientists and cool people!
PS: I also help co-managing @ZebrafishRock , so make sure to give them a follow for the latest zebrafish community news

I've closed my Twitter account, leaving behind almost 11,000 followers in favor of the 210 I have here. This decision was tough to make, but it was principled. Elon Musk is trying hard to open the door for the DTs and MTGs of the world, and if they seize more control, he will have something to do with it. It's time to wound him, even if that means wounding Twitter first. I've had enough.

#Introduction

I’m a Post-doc at the University of Oxford, working on the evolution of bacterial genomes and pangenomes. I’m interested in bacterial cooperation and ecology, and how these might interact with horizontal gene transfer.

I’m on the train to Manchester for the #MicroEvo22 meeting, where I’ll be presenting a poster (no. 17). Looking forward to seeing lots of you there!

#Bacteria #SocialEvolution #Plasmids #HorizontalGeneTransfer #Pangenomes #ComparativeGenomics

I’m a little late with an introduction post but we study #malaria transmission, particularly how changes in mammalian host #immunity and #metabolism control parasite transmission to and infection of the #mosquito host. We’re also interested in how malaria-induced activation of #basophils and #mast cells disrupts #intestinal barrier integrity. I’m passionate about #training that highlights the direct connections among #plant, #animal and #human health from the #cellular to the #ecosystem scales.

Do diverse microbial exposures inhibit type 2 immunity to allergens?

Recent paper from the Jameson lab suggests that co-housing SPF mice with pet store mice only temporarily inhibits ILC2 function.

nature.com/articles/s41590-022

The Coquet lab also has a preprint suggesting that high microbial content/diversity in mice does not inhibit allergic immune responses.

biorxiv.org/content/10.1101/20

A simplified view of the hygiene hypothesis has not been supported by these approaches #Immunology

Job ad: PostDoc Computational Metabolomics – Kiel Germany 

Do you enjoy #ComputerScience and want your work to have an impact on #plants #microbiome research?

Join the team of Eva Stukenbrock and me in #Kiel as a #PostDoc! Fully funded #job for 3 years in a beautiful place.

Apply ➡️ jobrxiv.org/job/kiel-universit

@jobsecoevo
(Photo: Jürgen Haacks / #KielUni)

'I also knew from Elmyr’s story that provenance—the history of who had owned an artwork and where it had been—could be a problem. So, rather than do a Chagall or Monet or Picasso painting, I decided to do a little drawing that was meant to be a fake Chagall, signed by de Hory, who, with the release of Fake!, had become notorious. '

lithub.com/how-a-forgery-of-a-

If you’re a shareholder in Tesla (auto maker), how do you feel about your staff working for Twitter? (On the team returning hate speech to the platform.)
washingtonpost.com/technology/

"A study has now linked APOE4 with faulty cholesterol processing in the brain, which in turn leads to defects in the insulating sheaths that surround nerve fibres and facilitate their electrical activity. Preliminary results hint that these changes could cause memory and learning deficits. And the work suggests that drugs that restore the brain’s cholesterol processing could treat the disease."


nature.com/articles/d41586-022

Hey there! I'm an Assistant Professor at #UCLA studying mouse and human #innateimmunity using #systemsimmunology and #crispr to find new targets for chronic viral infections, #T2D and #cancer. I mainly focus on #type1 immune responses including #NKcells #cDC1 and #ILC1. I started #earlycareerimmunology in 2021 to highlight underrepresented scientists early in their career. I'm here to post about #science, #art, #travel, #cat photos, and congratulate you on your wins 🥳🎉.

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