Thiago Carvalho @cyrilpedia@social.cleverlibre.org

First there were PAMPs (with a debatable 'P'). Then there were DAMPs. Somehow I'd missed plant HAMPs: herbivore-associated molecular pattern receptors

#PlantScience #InnateImmunity

https://elifesciences.org/articles/81050

"Here, we analyze the consequences for CD8+ T cells of STAT3 GOF SH2 (K658N) or TA (T716M) domain mutations in the mouse germline and in people with germline STAT3 GOF syndrome. The findings demonstrate that diverse STAT3 GOF mutations cause oligoclonal accumulation of T-LGL-like effector CD8+ T cells and that the accumulation of these rogue T cells contributes to autoimmune pathology."

#Immunology #Autoimmunity #immunity

https://www.cell.com/immunity/fulltext/S1074-7613(22)00591-X?rss=yes&utm_source=dlvr.it&utm_medium=twitter

From the Guardian's list of best science books 2022

'In This Mortal Coil (Bloomsbury), Andrew Doig, a biochemist at the University of Manchester, charts the fascinating history of how humans die. And if you think this might be a rather morbid topic, worry not. Despite some gruesome descriptions of disease and death, Doig tells an uplifting tale of how human ingenuity over the past few thousand years has allowed more of us to survive, and survive longer – first through innovations such as farming, and then by applying reason and evidence to health, defeating a host of major infectious diseases. For most of the history of our species, life expectancy was around 30. Today – thanks to the centuries of work by farmers, doctors, public health officials and others – people can expect to live to at least 70 or 80 in the world’s most developed nations.'

https://www.theguardian.com/books/2022/dec/03/best-science-books-of-2022?utm_term=Autofeed&CMP=twt_gu&utm_medium&utm_source=Twitter#Echobox=1670068856

'Farmer, who has doe eyes and a nonchalant smile, often wore scrubs on her sales routes, despite not having a medical background. That way, she said, “I would automatically be seen as a help.” She tried not to mention death in her opening pitch, or even hospice if she could avoid it. Instead, she described an amazing government benefit that offered medications, nursing visits, nutritional supplements, and light housekeeping—all for free. “Why not try us just for a few days?” she’d ask families, glancing down at her watch as she’d been trained to do, to pressure them into a quick decision.'

https://www.newyorker.com/magazine/2022/12/05/how-hospice-became-a-for-profit-hustle

'El colegio Colonial de Pirque fue uno de los cuatro establecimientos educacionales latinoamericanos premiados en la COP27 por su rol activo en responder a los desafíos del cambio climático. Entre los cuatro ganadores de este premio llamado “Guardianes del Clima” y otorgado por Unicef, la Fundación Meri y la Oficina de Educación Climática de la Unesco, se encuentran también un colegio de Honduras, otro de Colombia y otro más de Argentina. A nivel regional se presentaron 175 proyectos al certamen.'

https://elpais.com/america-futura/2022-12-02/el-exitoso-colegio-chileno-que-forma-agentes-frente-al-cambio-climatico.html

"Here, we developed a computational model to interrogate antibody evolution by affinity maturation after immunization with two types of immunogens: a chimeric heterotrimeric antigen that is enriched for the RBS epitope relative to other B cell epitopes, and a cocktail composed of three non-epitope-enriched homotrimeric antigens that comprise the chimera."

#Immunology #Preprint

https://www.biorxiv.org/content/10.1101/2022.12.02.518838v1?med=mas

'I remember as a young officer in Germany based next to Belsen concentration camp, being horrified by a memorial to the French Jews who had died there. It stated: “Aux Juifs français qui sont morts pour la gloire et la patrie.” I found the idea of French Jews dying for glory and the fatherland quite grotesque. Many years later I mentioned this to the French historian Henry Rousso. He replied: “I entirely understand your reaction, but you are completely wrong. It was the French Jews themselves who insisted after the war that memorials to their dead should have exactly the same wording as those of all the French. This was because they would never forgive Vichy for having tried to take away their French citizenship.”

#AntonyBeevor

https://www.prospectmagazine.co.uk/magazine/eurozone-democracy-antony-beevor?ref=the-browser