Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
My latest column for #NatureMedicine is a look at early human results of a new class of #antibiotics for #tuberculosis
The mechanism of action is essentially to clog the #mycobacterium's tRNA synthetase - the result of two decades of research on boron-based compounds.
Thiago Carvalho
boosted
Listening to @FeministKelly Unsung History podcast and especially the episode about chef Lena Richard's story left me deeply touched, inspired and euphoric. If I wasn't already a food historian, I would have become one at this point 🤯
https://www.unsunghistorypodcast.com/lena-richard/
#FoodHistory #Herstory #UnsungHistory #FoodStudies #WomenHistory #BlackHistory
'Fifteen scientific journals published a total of 812 (68.7%) of all 1182 papers retracted for being paper mill papers, and 166 (14.0%) were published in one journal, the European Review for Medicaland Pharmacological Sciences. Of these, all journals appear to be non-predatory journals.'
#ScientificPublication #PaperMills #ResearchIntegrity #PeerReview
Thiago Carvalho
boosted
Faculty at more prestigious universities publish more bc they have funded Ph. D. students and postdocs to do the work.
In fields where advisors aren't put on Ph. D./postdoc research pubs, there is no relationship between university prestige and faculty productivity.
Mid-career faculty, matched, who move to institutions with more funded Ph. D./postdocs publish more.
Counting pubs is a poor method of judging a researchers quality.
It seems the Times has found your timeline, @christlet
"Gritty Marseille, France, Is Now a Haven for Creatives"
https://www.nytimes.com/2022/12/02/t-magazine/wanderlust-marseille-france.html
Thiago Carvalho
boosted
Thanks so much to everyone who has said hi to me here, so nice to have a warm welcome. To those who are reading me here for the first time, I'm a science writer and author of "NeuroTribes: The Legacy of #Autism and the Future of #Neurodiversity." I'm also a music writer, #Deadhead, #BeatGeneration enthusiast, and @osiris podcaster. Hey all! #introduction
The S in Stanford's original SAB did not stand for "Scientific":
'Among her advantages in their increasingly frosty relationship was her continued communication with her dead husband and son – ‘my two spiritual advisers’, as she called them – whose deceased status rendered them infallible. Under their guidance she laid out a pedagogic vision requiring Stanford students to be taught that ‘every one born on earth has a soul germ’
https://www.lrb.co.uk/the-paper/v44/n23/james-lasdun/stop-all-the-cocks
'A pulse/chase experiment comparing chronically infected to treated animals showed that recently divided Ifng+ T cells, particularly IFN-γ+TNF+IL-2− T cells, are promoted by persistent infection. These data suggest that low-level persistent infection reduces CD4+ Tmem survival and multi-functional Teff but promotes IFN-γ+TNF+IL-2− Late Effector Memory and Terminally Differentiated Effector T cells and prolongs immunity.'
https://www.biorxiv.org/content/10.1101/2022.12.01.518804v1?med=mas
Thiago Carvalho
boosted
#Drosophila #Advent Day4: On with the obscura group! Drosophila tristis is also a sap-flux feeder, but is less common than Dobs https://www.nature.com/articles/1721155b0. I think it likes older yeast baits, and it’s reported to prefer canopy traps. Males are distinctively melancholy in their dark mourning dress, but female ID requires a microscope (palps and oviscapt). It has potentially interesting P-elements https://cdnsciencepub.com/doi/abs/10.1139/g96-122 , Wolbachia https://resjournals.onlinelibrary.wiley.com/doi/full/10.1111/j.0307-6946.2005.00715.x and viruses https://journals.sagepub.com/doi/10.4137/EBO.S39454
Thiago Carvalho
boosted
RT @HaoYin20@twitter.com
A mind-blowing Science paper from Dr. Bin Zhou lab🤯
Genetically Labeling/Tracing Cell Contact events & post-contact consequences
Tigre-SynNotch + Cre & Dre transgenic🐭
One can track Ongoing+History of Contact (likely minimal 2-h) b/w 2 cell types
https://www.science.org/doi/10.1126/science.abo5503
Thiago Carvalho
boosted
#IDMastodon #Immunology Understanding #SarsCoV2 shedding characteristics is relevant for public health interventions. viral load and shedding kinetics is influenced by biological characteristics of🦠 , host factors & pre-existing immunity (previous infection or vaccination) of the infected individual.
@Nature
https://www.nature.com/articles/s41579-022-00822-w?utm_source=twitter&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_NATUREPORTFOLIO
Thiago Carvalho
boosted
Hello Mastodon!
Thiago Carvalho
boosted
Expansion microscopy is one of the best things to come along in #cellbiology. A new preprint from Ons M’Saad in the Bewersdorf lab at Yale describes methods for ~8000-fold volumetric expansion and labeling that deals with the dilution problem associated with such huge expansion. Cell-level details can be observed with a cell phone camera!
Thiago Carvalho
boosted
Introducing @emboreports to the fediverse!
We are a society-owned primary @EMBOPress #research #journal publishing papers, reviews and science & society commentaries from all areas of molecular #LifeScience #cellbiology #biochemistry #molecularbiology #immunology #microbiology #cancer #development #structure #signaling and many more.
Check us out: https://embor.embopress.org
Thiago Carvalho
boosted
Hecatomb: An End-to-End Research Platform for Viral Metagenomics | bioRxiv
"To me, one of the outstanding, clear failures in this pandemic—one that is fixable—is the way the vaccine rollout went. We were in an emergency and there was a limited supply and it meant rich countries were going to get vaccines first. To me, it is such an obvious problem to have a pandemic continue to surge for more than a year in a large part of the world, despite the availability of vaccines in a select number of countries."
Thiago Carvalho
boosted
Le #CNRS demande désormais à ses chercheurs et chercheuses d’appliquer la stratégie de non-cession des droits d’auteur (CC-BY 4.0) lors du dépôt de leurs articles auprès d’éditeurs.
Thiago Carvalho
boosted
RT @leslievosshall
Pls RT: the 2024 @HHMINEWS Investigator Competition officially opens for applications on Tuesday December 6. Check embedded 🧵 below for major enhancements that align with our values: open science, DEI, mentoring 1/4 https://twitter.com/leslievosshall/status/1585798911754530816
Thiago Carvalho
boosted
Intro post: We are a #Immunology lab at the Rockefeller University in NYC. We're interested in B cells and the #antibodies they make. We also develop LIPSTIC technologies to study how immune cells interact.
Shamelessly plagiarizing @ct_bergstrom, here's a perfect germinal center for your trouble.
Thiago Carvalho
boosted
An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
