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RT @pabloimmune
Happy to share our small contribution to the IgA2 mystery ⁦@MehandruLab⁩ ⁦@SinaiImmunol⁩ for now in preprint form ⁦in @medrxivpreprint⁩ medrxiv.org/content/10.1101/20

"Here, Sarden et al. aimed to characterize the mechanism by which resistance to Af fails in some individuals. The authors found that an axis consisting of innate B1a cells, natural IgG antibodies, and neutrophils is essential for maintaining protection against Af infection in preclinical models. This axis can be disrupted by factors ranging from influenza A and SARS-CoV-2 infection to corticosteroid treatment. Importantly, the authors showed that re-establishing this axis, including by administration of Af¬-reactive antibodies, can protect mice, highlighting a potential treatment"

science.org/doi/10.1126/scitra

How did I not know about this movie?

"8. True Confessions (1981)
Duvall and Robert De Niro get the best out of each other in Ulu Grosbard’s intelligent movie, co-written by Joan Didion and John Gregory Dunne, and based on Dunne’s novel inspired by the Black Dahlia case. Duvall plays a tough LAPD detective in the 40s, haunted by a corrupt past that he has put behind him. His younger brother is De Niro’s idealistic young catholic priest, who receives donations from a somewhat shady businessman. A gruesome murder brings the two into a mutually anguished confrontation."

theguardian.com/film/2022/dec/

In honour of tonight's gorgeous #FullMoon, here is one of my favourite Japanese #ukiyoe prints: 'Bat Before the Moon' - Biho Takashi, 1910.
#JapaneseArt #japodon #bat #moon

'Sadly, my colleagues and I were to become far more familiar with life-threatening parasitic infections. In the early years of the aids epidemic, I lost many of my patients to them. An aids patient’s devastated immune system might allow the parasite Toxoplasma gondii, carried by cats, to form brain abscesses; Cryptosporidium infection, which normally infests cattle, caused wasting from relentless diarrhea.'

newyorker.com/magazine/2022/12

The Department of Defense doesn't want this, but some want to go after vaccination for personal, political gain. This is a non-issue manufactured by bad people.

vox.com/policy-and-politics/20

The lab is hiring a 3 year #postdoc for a new project aiming to use HUGE language datasets from digital therapy to (i) understand fundamentals of depression and its temporal dynamics and (ii) use these data to measure and predict responsiveness to therapy.

@NicoleCRust @complexsystems @cogneurophys @PessoaBrain @SussilloDavid @carlosbrody @Neurograce @neuralreckoning @tyrell_turing @DrYohanJohn @cian @WiringtheBrain @tdverstynen @neuralengine

For modeling complex behavior, I've been really excited about frameworks coming out of computer animation, such as Zhang et al 2018 "Mode-adaptive neural networks for quadruped motion control" dl.acm.org/doi/10.1145/3197517

The architecture and training protocol are relatively simple, but produce complex and qualitatively accurate behavior!

Of course this kind of network is not biologically plausible, but I think you can start from it and add more and more biology while preserving the ability to model complex motion. Combining this kind of model but using one of the models in this thread as a base could work well, for instance, or (as in my work) adding more realistic sensors and actuators for the network and seeing the limit of movement.

Hi all! I'm an Assistant Professor at Dickinson College in the chemistry department. I make new bioluminescent proteins, probes, and tools. I'm interested in better ways to teach Organic Chemistry. I saw that @bertozzi was here (my academic grandmother via Jenn Prescher, lol) and decided to join! Excited to become a part of science mastodon!

#introductions #chembio #chemicalbiology #bioluminescence #organic #python #glycotime

“But I’m #newhere / will you show me around”
(Bill Callahan, 2006)

Ok, after looking around a bit, finally time for proper #introduction

I am a #biochemist and former #researcher, still fond of #ubiquitin and #cellcycle stuff!
I work now as full-time #LifeScience #editor for @embojournal, interested in #scicomm #reproducibility #researchintegrity

I may not directly toot about them, but other things I am looking for here are #cycling, #photography, #outdoors, #languages, #history, #music…

in Switzerland

The Federal health authority has mistakenly declared only half of the COVID-19 hospitalisations of the past 2 years.
Almost one in 100 swiss has been hospitalized due to covid19 so far.

tagesanzeiger.ch/neue-daten-ze

Here we go, it’s time:

I’m currently a second year student at the University of Pennsylvania! Broadly interested in and with my current research studying higher-level vision in the with the goal of learning about visual 🧠

I also love talking/reading/posting about and 🌎, hanging out with my dog 🐕‍🦺, and playing soccer ⚽️

Looking forward to (re)connecting with other scientists on here!

'What do you give the queen who has everything? When Mark Antony was wondering how to impress Cleopatra in the run-up to the battle of Actium in 31BC, he knew that jewellery would hardly cut it. The queen of the Ptolemaic kingdom of Egypt had recently dissolved a giant pearl in vinegar and then proceeded to drink it, just because she could. In the face of such exhausted materialism, the Roman general knew that he would have to pull out the stops if he was to win over the woman with whom he was madly in love. So he arrived bearing 200,000 scrolls for the great library at Alexandria.'

theguardian.com/books/2022/dec

#^Why did consciousness evolve?


How the advent of consciousness 500 million years ago gave way to an evolutionary ‘arms race’ in sophisticated thinking
- by Aeon Video

Watch at Aeon

We are recruiting!
Two openings for a scientific #editor to join our team. Applications close December 11th.
@EmboMolMed @MolSystBiol @embojournal
For more info and to apply: embo.org/about-embo/work-for-u

We are now on Sciencemastodon! #Introduction

We are a peer-reviewed #openaccess journal dedicated to high quality research at the interface between clinical & basic science.

We publish primary research and reviews on translational research in the fields of #cancer, #neurodegeneration, #MetabolicDiseases, #GeneticDiseases, #Immunology, #CardiovascularDiseases, and more!

Check us out: embomolmed.embopress.org

RT @NCIResearchCtr@twitter.com

#NowHiring Dr. Samira Sadowski @samira_sadowski@twitter.com is recruiting for a post-baccalaureate fellow to join her lab @NCICCR_SurgOnc@twitter.com. Learn more about this #CCRTraining opportunity here: ccr.cancer.gov/careers/post-ba

🐦🔗: twitter.com/NCIResearchCtr/sta

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