Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Madalena has been on a #ceramics rampage for a few months now.
Here's a cephalopod for the New Year.

#ArtMastodon

More at the link below

https://madalenaparreira.com

The team at STAT picked this NYT piece on the opiod crisis as one of the top stories of the year.

Surprising absolutely no one, McKinsey made a buck from it

'Opana’s manufacturer, the pharmaceutical company Endo, had scaled back promotion of the drug. But months later, the company abruptly changed course, refocusing resources on the drug by assigning more sales representatives.

The push was known internally as the Sales Force Blitz — and it was conducted with consultants at McKinsey & Company, who had been hired by Endo to provide marketing advice about its chronic-pain medicines and other products.'

#Opiod #OpiodCrisis

https://www.nytimes.com/2022/06/29/business/mckinsey-opioid-crisis-opana.html?partner=slack&smid=sl-share

A bit outside what we normally get, but a very nice white from Pico, in the Azores.

#WinesOfMastodon

'Goethe considered the Newtonian theory to be a mathematical abstraction in contrast with the testimony of the eyes, and thus downright absurd. In fact, he claimed that light is the most simple and homogeneous substance, and the variety of colours arise at the edges where dark and light meet. Goethe set the Greeks’ approach to colour against Newton’s for their having caught the subjective side of colour perception. The Greeks already knew, Goethe wrote, that: ‘If the eye were not Sun-like, it could never see the Sun.’

https://aeon.co/essays/can-we-hope-to-understand-how-the-greeks-saw-their-world

"Extensive studies have highlighted the importance of ApoE, Trem2, and the complement pathway in aspects of AD pathological development and progression. There is increasing evidence that immune signaling pathways are also prominent in AD-associated immune cellular changes and play potentially important roles in AD pathology."

#Alzheimer #AlzheimersDisease
#Immunology #Neuroimmunology @ImmunityCP

https://www.cell.com/immunity/fulltext/S1074-7613(22)00557-X

You can add Lisbon to this 'unlike' list.

"But the thing that really surprised me when I moved here was how reasonable the rents are compared with London, New York and most other European capitals. The reason for this is Vienna City Council’s radical social housing policy. It is the largest property owner in Europe. Some 60 per cent of the population live in high-quality subsidised housing, including middle-class families and young professionals. Unlike London, nurses, teachers and public servants can afford to live in the centre."

https://www.ft.com/content/05719602-89c6-4bbc-9bbe-5842fd0c3693

As @miguelgf pointed out to me years ago, this trend in telomere length variation is also seen between wild populations and lab mice

"We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strains than in the established strains."

https://academic.oup.com/nar/article/28/22/4474/2383801

"A strange text first found embedded in the Alexander Romance, and later in stand-alone Latin and Old English versions, purports to be a letter from Alexander to Aristotle describing the wonders of ‘India’ (a term that, in this context, denotes a vaguely defined Far East). Manuscript illustrators delighted in the plethora of fabulous beasts and human grotesques that the letter records: dragons, griffins, sirens, wild men and women, and the comical Sciapods (‘shadow-feet’), contorting themselves to hold a single huge foot up in the air to act as a parasol"

https://www.lrb.co.uk/the-paper/v45/n01/james-romm/at-the-british-library

"Adulthood-only downregulation of insulin/IGF-1 signaling (IIS), an evolutionarily conserved pathway regulating resource allocation between somatic maintenance and reproduction, increases life span without fecundity cost in the nematode, Caenorhabditis elegans. However, long-term multigenerational effects of reduced IIS remain unexplored and are proposed to carry costs for offspring quality."
cc @Odedrechavi
#Celegans #Epigenetics #Insulin

https://onlinelibrary.wiley.com/doi/10.1111/evo.14640?af=R

'The recent publication of the genomes of over 1000 S. cerevisiae strains enabled us to explore telomere DNA length variation at an unprecedented scale. Here, we developed a bioinformatic pipeline (YeaISTY) to estimate telomere DNA length from whole-genome-sequences and applied it to the sequenced S. cerevisiae collection. Our results revealed broad natural telomere DNA length variation among the isolates. Notably, telomere DNA length is shorter in those derived from wild rather than domesticated environments.'

#Telomeres #Domestication

https://academic.oup.com/genetics/advance-article-abstract/doi/10.1093/genetics/iyac186/6958701?redirectedFrom=fulltext