Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
γδ T cells are effectors of immunotherapy in cancers with HLA class I defects
Thiago Carvalho
boosted
RT @stephaniehicks@twitter.com
I taught two 8-wk courses this fall @JohnsHopkinsSPH@twitter.com and wanted to share the resources (built in #quarto!) in case others starting in #Rstats #DataScience find it useful
🤩 Intro to R
https://www.stephaniehicks.com/jhustatcomputing2022/schedule
💃 More adv R #Git #CommandLine #SQL #APIs
https://www.stephaniehicks.com/jhustatprogramming2022/schedule
🐦🔗: https://twitter.com/stephaniehicks/status/1613500868271161346
Thiago Carvalho
boosted
A nucleosome is a structural unit of a eukaryotic chromosome, consisting of a length of #DNA coiled around a core of histones. Explore the x-ray crystallography data and #3Dprint the #Nucleosome COMPASS Complex. #genetics #biotech #CRISP https://buff.ly/3Xo6Dx3
ON meeting your heroes
(From Gabriel Byrne's "Walking with Ghosts: A Memoir")
Thiago Carvalho
boosted
A critical period of prehearing spontaneous #calcium #spiking is required for #hairbundle maintenance in inner hair cells
Walter Marcotti and colleagues Sheffield University
https://www.embopress.org/doi/full/10.15252/embj.2022112118
Thiago Carvalho
boosted
🎉 Included in our Top 100 Downloaded Articles in 2022 Collection. Explore 'Whole Inactivated Virus and Protein-Based COVID-19 Vaccines' by Maria Elena Bottazzi and Peter J. Hotez, either #OpenAccess or freely available to download through the collection https://arevie.ws/3X9pD2A
'On June 28, 2022, researchers from Pfizer–BioNTech and Moderna presented data on their bivalent vaccines to the FDA’s Vaccines and Related Biological Products Advisory Committee (of which I am a member). The results were underwhelming. Bivalent boosters resulted in levels of neutralizing antibodies against BA.1 that were only 1.5 to 1.75 times as high as those achieved with monovalent boosters.'
Thiago Carvalho
boosted
Great collaborative effort with the Laurent Terradot team on two new #Brucella effectors modulating nuclear proteins just published in Nature Communications. Massive work by outstanding young scientists Arthur Louche and Amandine Blanco who combined #StructuralBiology, #InfectionBiology and a bit of mythology for naming the proteins, and ended up with a lot more questions than when we started!
Congrats to all involved
#Microbiology #Bacterial #Pathogenesis
https://www.nature.com/articles/s41467-022-35763-8
Thiago Carvalho
boosted
A review paper from @lapassmore on transcription termination @MolecularCell
"Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII"
https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01178-9
Thiago Carvalho
boosted
New open access review out by Paddy Gibson and myself in Current Opinion in Microbiology on bacterial/#pneumococcal cell wall biology and penicillin/amoxicillin resistance. Issue edited by @goleylab Peter Chien. Lot's of new insights into bacterial cell wall biology have been made recently and we tried to cover it all. I really like this figure as it nicely highlights our current knowledge gaps and big open questions in the field.
https://www.sciencedirect.com/science/article/pii/S136952742200145X
Thiago Carvalho
boosted
RT @GuertinLab@twitter.com
The Cold Spring Harbor Gene Expression course is such an immersive experience, learning molecular biology and genomics methods, 2 hour interactive seminars with new and old scientists leading the field—apply: https://meetings.cshl.edu/courses.aspx?course=C-gnx&year=23
🐦🔗: https://twitter.com/GuertinLab/status/1613255371665055746
'Long-lasting sepsis-induced immunoparalysis has been principally studied in primary (1°) memory CD8 T cells; however, the impact of sepsis on memory CD8 T cells with a history of repeated cognate Ag encounters is largely unknown but important in understanding the role of sepsis in shaping the pre-existing memory CD8 T cell compartment.'
'A surge in winter sickness in the northern hemisphere and reduced exports from China have meant patients have found it difficult to get hold of some basic medicines such as penicillin and paracetamol. Almost all 27 EU member states and the UK have reported shortages.
Under pressure from governments, the commission has said it will intervene to ensure “strategic autonomy” in basic medicines through a “systemic industrial policy”.
https://www.ft.com/content/40de511f-7203-4d60-b33d-695d2360e349
'They found that the inner ears of small and young E. holgeri individuals were almost as large as those of their adult counterparts, and very similar in shape. Given that inner ears have roles in both audition and the sense of equilibrium, this suggests that E. holgeri babies were able to leave their nest very soon after hatching. This makes it likely that the babies of the species were highly developed when they hatched, and could probably feed themselves almost immediately, possibly similar to chickens'
#Evolution #Paleontology #Sauropods @elife
https://elifesciences.org/articles/82190
Thiago Carvalho
boosted
Hi @Quartzy - is it true that from July onwards you will be charging also academic labs for using your basic order tracking system ($79/5 users)? Do I remember your #freeforever pledge correctly? Thanks for clarifying. #AcademicChatter
Thiago Carvalho
boosted
OK sounds like #EvolgenPaper is good hashtag for adding to toots and threads on Evolutionary and Population Genetics papers
We could use #EvolutionPaper for papers more generally associated with Evolutionary Biology.
Please RT this and consider using these for tooting about papers, your own of those of others. That way we'll be able to keep track of them all more.
Thiago Carvalho
boosted
How does neural activity relate to #perception?
Perceptography combines clever machine learning with #optogenetics to generate the pictures that are likely to be experienced during neural stimulation. Fascinating #preprint by Elia Shahbazi &
Afraz Arash!
Thiago Carvalho
boosted
As the U.S. pushed #Native Americans from their lands for westward expansion, museums and the federal government encouraged the looting of #Indigenous remains, funerary objects and cultural items. 30 years since passage of the Native American Graves Protection and Repatriation Act, @ProPublica investigates the #failure of federally funded universities and museums to expeditiously return human remains.
“We never ceded or relinquished our dead. They were stolen."
https://www.propublica.org/article/repatriation-nagpra-museums-human-remains
Thiago Carvalho
boosted
An extra layer lines the brain “similar to the mesothelial membrane lining of peripheral organs and body cavities, it encases blood vessels and harbors immune cells”
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
