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❤️
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RT @LulaOficial
Hoje agradeci os trabalhadores que limparam e reergueram o Palácio do Planalto em pouquíssimos dias, depois do estrago feito por vândalos. Esse é um patrimônio do povo brasileiro, de todos nós. Muito obrigado.

📸: @ricardostuckert
twitter.com/LulaOficial/status

Here’s some cleared postnatal cerebellum #microscopy #EyeCandy to continue my #neuroscience #introduction. This image volume was acquired by Niraj Trivedi in my lab on an UltraMicroscope II. Magenta is the nucleus of all proliferating cerebellar granule #neurons in the external granule layer 🤩 These cells proliferate faster than a tissue culture cell line in a dish 🤯

Please feel free to reach out to me with any questions about the role, the journal or the team (also to eg @RoliRoberts if questions are about me 😉)
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RT @npariente
Are you an #editor with expertise in #neuroscience? Come join our team!
This might be the right next step for you -we are looking for our next Neurobiology Section Manager, key position in the @PLOSBiology team
To apply (considered upon receipt) plos.io/3kh5ARD
#ca…
twitter.com/npariente/status/1

California Attorney General Sues Drugmakers Over Inflated Insulin Prices khn.org/MTYwNjY3MQ via @khnews

Extraordinary claims require extraordinary evidence.
I wrote a review/comment on #biorXiv about the issues I see with this #cryoEM #preprint:

biorxiv.org/content/10.1101/20

Lots of questions about if future SARS-CoV-2 variants might be more or less severe.

I don’t have a crystal ball.

But in this thread, I’ll describe what happened w other rapidly evolving respiratory viruses after initial pandemic, & describe some relevant SARS-CoV-2 data.

Plot below shows mortality due to influenza virus in USA during and after 1918 H1N1 & 1968 H3N2 influenza pandemics.

Interactive version of plot is at jbloomlab.github.io/flu_mortal and data are taken from academic.oup.com/jid/article/1

"However, binding and neutralization have poorly predicted protection in the past, and accumulating data across epidemiologic cohorts and animal models collectively point to a role for additional antibody Fc-effector functions. To begin to define the humoral correlates of immunity against RSV, here we profiled an adenovirus 26 RSV-preF vaccine-induced humoral immune response in a group of healthy adults that were ultimately challenged with RSV."

cell.com/cell/fulltext/S0092-8

I’d been hearing about the coal-mine protests in Germany, but this photo by Sean Gallup is the first that gave me a real sense of the titanic size of the thing and what’s being protested. Just… unreal.

'The threat of this outbreak almost restarted efforts to test a new vaccine for the strain of Ebola that generated these infections. The work had previously been abandoned due to lack of financing, profit, and political will. The outbreak ignited a spark of hope, but it looks to have subsided before the vaccine trials could be implemented.'

statnews.com/2023/01/11/4-gaps

"We have discovered the Caenorhabditis elegans homeodomain-interacting protein kinase (HPK-1) acts as a key transcriptional effector to preserve neuronal integrity, function, and during ."

biorxiv.org/content/10.1101/20

" But once you experience #Mastodon, you suddenly realize just how much advertising, spam, and phishing you are being force-fed. I find Mastodon restful. Like the first time you realized that TV is possible without commercials. Also, because journalists and scientists are leading the charge to Mastodon, my feed seems to reflect a culture of knowledge, even leaning on peer-reviewed citations."

#TwitterMigration

psychologytoday.com/intl/blog/

RT @jwoodgett@twitter.com

Some thoughts on core facilities.
1. These are enormous all-boat lifters if supported well.
2. They should be run by experts who are commensurately valued and supported. This is a career path. Include names on papers if they’ve contributed insight, even if fee-for-service. /1

🐦🔗: twitter.com/jwoodgett/status/1

Our latest issue is full of wonderful #OpenAccess #DiseaseBiology science & a generous sprinkling of community spirit:

🦠Professors Pascale Cossart and Serge Mostowy reflect on Louis #Pasteur's legacy
🧠A Special article discusses the bench-to-bedside pipeline in #neuroscience
🐟A new way of seeing #disease processes in a transparent #fish D.cerebrum:

📖journals.biologists.com/dmm/is

Tools

"For a CRISPR guide RNA (gRNA) with a specific target but activity at known "off-target" sequences, we present a method to screen hundreds of thousands of gRNA variants with short, randomized 5' nucleotide extensions near its DNA-targeting segment"

biorxiv.org/content/10.1101/20

"Keaton had been on the stage longest, risen the highest, fallen the furthest, and, thanks to the medium of film which preserved his artistry, left the most indelible legacy. ‘He was,’ Orson Welles said, ‘as we’re now beginning to realise, the greatest of all the clowns in the history of the cinema.’"
John Lahr @lrb


lrb.co.uk/the-paper/v45/n02/jo

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