Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"Where Brod strove to clean Kafka up and foster a sense that he was, in Benjamin’s words, a “saintly, prophetic genius, whose purity places him at an elevated remove from the world,” this edition scuffs him up and returns him to earth, in an intimate manner that does no injury to our sense of his suffering, or his profound and original gifts."

https://www.nytimes.com/2023/01/11/books/kafka-diaries.html

"The differential effects of anti-CD20 treatment on CD4+ and CD8+ T cell subsets point to different contributions of direct removal of CD20-expressing T cells, as well as indirect effects likely reflecting the removal of B cells that alters in vivo T cell:B cell interactions."

#Immunology #MultipleSclerosis #Immunotherapy #Autoimmunity #CD20

https://www.pnas.org/doi/10.1073/pnas.2207291120

'Every sensitive reader has pet peeves. One of mine is attributing the power of sight to things that don’t have eyes, as in this sentence from the Wall Street Journal: “Restaurant sales are expected to see a warming trend this spring as menu prices rise and consumers spend more.”

https://www.newyorker.com/culture/annals-of-inquiry/the-objectively-objectionable-grammatical-pet-peeve

A shot from a spectacular film, Francesco Rosi's "Cristo si è fermato a Eboli" (Christ Stopped at Eboli).

'Mitonuclear interactions would therefore exert an influence on evolutionary trajectories. One prediction from this model is that the same nuclear genomes but evolving with different mitochondrial haplotypes would follow distinct molecular paths towards higher fitness peaks.'

#Evolution #EvolutionaryBiology #preprint #mitochondria

https://www.biorxiv.org/content/10.1101/2022.09.11.507487v3

Nautilus

“Anderson Torres took over as secretary of security, dismissed the entire command and travelled,” says Ricardo Cappelli, the federal government official who is temporarily in charge of security in Brasília. “If this isn’t sabotage, I don’t know what is.”

https://www.ft.com/content/a6143da4-50ae-4a69-ba29-190a8bfa37c1

"Here, we show that cGAMP delivery by intratumoral injection of virus-like particles (cGAMP-VLP) led to differentiation of circulating tumor-specific T cells, decreased tumor regulatory T cells (Tregs), and antitumoral responses that synergized with PD1 blockade."

#STING #Immunology #Immunotherapy #checkpointinhibitors

https://www.science.org/doi/10.1126/sciimmunol.abn6612#.Y8G4gZis1IU.twitter

'When ‘precolonial’ is used for describing African ideas, processes, institutions and practices, through time, it misrepresents them. When deployed to explain African experience and institutions, and characterise the logic of their evolution through history, it is worthless and theoretically vacuous. The concept of ‘precolonial’ anything hides, it never discloses; it obscures, it never illuminates; it does not aid understanding in any manner, shape or form.'

Olúfẹ́mi Táíwò @aeon_co

https://aeon.co/essays/the-idea-of-precolonial-africa-is-vacuous-and-wrong

'La petición se basa en que el político ultraderechista publicó este martes, dos días después de la invasión protagonizada por miles de sus seguidores, un vídeo en redes sociales que eliminó después. En el clip, un fiscal bolsonarista ponía en duda el resultado de las últimas elecciones, que Bolsonaro perdió frente a Luiz Inácio Lula da Silva, presidente desde hace 13 días.'

https://elpais.com/internacional/2023-01-13/la-fiscalia-de-brasil-pide-que-el-expresidente-bolsonaro-sea-investigado-por-el-asalto-en-brasilia.html

"This observation raises a question of fundamental importance: if natural mucosal respiratory virus infections do not elicit complete and long-term protective immunity against reinfection, how can we expect vaccines, especially systemically administered non-replicating vaccines, to do so? This is a major challenge for future vaccine development, and overcoming it is critical as we work to develop “next-generation” vaccines."

Perspective @cellhostmicrobe by David Morens, Jeffery Taubenberger & Anthony Fauci

#Vaccines #PublicHealth #Vaccine Development #Virus #Virology #Immunology #Coronavirus #Covid #Covid19 #Influenza #RespiratoryVirus #MucosalImmunology

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00572-8

"We found that TCR signal intensity coupled STING signal strength to the unfolded protein response (UPR) and T cell survival. Under strong STING signaling, Indoleamine-pyrrole 2,3-dioxygenase (IDO) inhibition also reduced apoptosis and led to a recovery of T cell memory in STING sufficient CD8 T cells."

#Immunology #STING #Tcells
#ImmunologicalMemory

https://www.pnas.org/doi/10.1073/pnas.2205049120