Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'He added that Bayer was “deprioritising Europe to some degree” and focusing on the US and China, where its pharma division has already established a significant market presence.'

https://www.ft.com/content/f2f7ee6f-0d81-419a-b8e8-da2d3919cf47

"Adolfo Kaminsky’s talent was as banal as could be: He knew how to remove supposedly indelible blue ink from paper. But it was a skill that helped save the lives of thousands of Jews in France during World War II."

https://www.nytimes.com/2023/01/09/world/europe/adolfo-kaminsky-dead.html

"In the current study, we compared three different formulations for saRNA, a cationic polymer (pABOL12), a lipid emulsion (nanostructured lipid carrier, NLC13), and three lipid nanoparticles (LNPs). We investigated the early inflammatory profile after immunization and explored how that related to downstream adaptive immune responses. We then explored the role of RNA sensing on the adaptive immune response to vaccination."

#InnateImmunity #Immunology #RNAVaccine #Vaccines

https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(22)00316-X

"The US National Science Foundation (NSF) has decided not to include a question about sexual orientation on one of its workforce surveys, setting off a social-media firestorm. More than 1,700 researchers have now signed an open letter urging the agency’s director to reconsider the decision. They argue that it is crucial to collect such information to understand the makeup of the scientific community and craft policies that lessen disparities for sexual minorities."

https://www.nature.com/articles/d41586-023-00082-5

"It will take months for Medicare to determine which price increases will prompt rebates and how much the rebates will amount to. But the Congressional Budget Office has estimated that this provision will save Medicare more than $56 billion over 10 years."

https://www.nytimes.com/2023/01/14/health/medicare-drug-prices.html?action=click&module=Well&pgtype=Homepage&section=Health

From "Dreyer's English", by Benjamin Dreyer.

Rood et al in #NatureMedicine on the 'Impact of the Human Cell Atlas on medicine'.

"The healthy reference atlas, diseases atlases, and underlying lab and computational methods should allow for the development of new assays with higher resolution and broader molecular scope, as well as improved interpretation of results from individual patients "

I discussed the topic with Steve Quake on the most recent episode of the #EMBOPodcast.

https://www.embo.org/podcasts/the-biologists-were-pretty-darn-good-with-their-microscopes/

https://www.nature.com/articles/s41591-022-02104-7

"Colograph

The works presented here are created with alternative materials rather than etched on copper. From squashed paper costumes to packaging and leather book covers, objects are inked with different processes, both intaglio and planographic. Scales vary and are usually life-size. The paper costume prints are mostly made from real costumes (with the exception of the long dress, which is a smaller scale model) , worn by actors in a film project and subsequently smashed, inked and printed on cotton paper."
https://madalenaparreira.com/Colographs

"Loss of function screens using shRNA and CRISPR are routinely used to identify genes that modulate responses of tumor cells to anti-cancer drugs. Here, by integrating GSEA and CMAP analyses of multiple published shRNA screens, we identified a core set of pathways that affect responses to multiple drugs with diverse mechanisms of action."

#preprint

https://www.biorxiv.org/content/10.1101/2023.01.02.522527v1?med=mas