Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Repeatability of adaptation in sunflowers: genomic regions harbouring inversions also drive adaptation in species lacking an inversion http://biorxiv.org/cgi/content/short/2023.02.17.528989v1?rss=1 #biorxiv #EvoBio #preprint
"Ever since, he has been exploring organoid opportunities — in drug screening, disease modelling, clinical trial design and personalized medicine — in his academic lab, through biotechs and via scientific advisory boards. When he was offered the job as the head of Pharma Research & Early Development (pRED) at Roche, he jumped at the chance to take this organoid research to the next level."
'Now, scientists have discovered that Leonardo did detailed experiments that sought to illuminate the nature of gravity a century before Galileo and some two centuries ahead of Newton’s making its investigation an exact science. The scientists’ study of his gravitational ideas and experimentation was published earlier this month in the journal “Leonardo.”
"Like London’s fabled buses, you wait an age for a good book on England’s 17th century of civil wars, regicide and revolution — and then two, even three, come along almost at once."
https://www.ft.com/content/4cc66568-c1b8-4d67-b076-db1654a41496
"The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly interrogate the role of γc cytokines in inflammatory and autoimmune disease settings. Here, we generated a γc cytokine receptor antibody, REGN7257, to determine whether γc cytokines might be targeted for T cell–mediated disease prevention and treatment."
'These findings support the continued development of mRNA-1893 against Zika virus, which was well tolerated at all evaluated dose levels and induced strong Zika virus-specific serum nAb responses after two doses, regardless of baseline flavivirus serostatus.'
#Zika #immunology #Virology #mRNA #Vaccine
https://www.sciencedirect.com/science/article/abs/pii/S1473309922007642
Thiago Carvalho
boosted
The case for free-range lab mice
https://www.newyorker.com/culture/annals-of-inquiry/the-case-for-free-range-lab-mice
Thiago Carvalho
boosted
Age old debate. When inferior may not really be inferior.
In this case, does a negative urine after treatment really indicate a better clinical outcome? (personally, no)
#IDMastodon #MedMastodon #AMR #antibiotics #microbiology #urine #academia
Antimicrobial for 7 or 14 days for febrile urinary tract infection in men: a multicenter noninferiority double blind placebo-controlled, randomized clinical trial | Clinical Infectious Diseases
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciad070/7035974
Thiago Carvalho
boosted
Hello, do you have a moment to talk about the battle of Armageddon?
Thiago Carvalho
boosted
My latest Clinical Pipeline column for #NatureMedicine is out, a look at Moderna's RNA vaccine for RSV & a survey of what's, well, in the pipeline, for RSV immunotherapies, including vaccines and monoclonals.
#Vaccine #drugdiscovery #drugdevelopment #mRNA #RSV #immunology #MonoclonalAntibody
Thiago Carvalho
boosted
Print by Madalena Parreira & Constança Arouca
“Map 10 The Turbulence Chart (Lviv, Ukraine, circa 1890)
This engraving was part of a set that illustrated the fabled, never published, “Order & Disorder” manuscript by Bronislaw Zamoyski (sometimes referred to as the “Leibniz of Lviv”). The text and all accompanying illustrations were thought to have been lost when the Russian Army captured Lviv in 1914. How it was obtained by von Willebrand remains unknown.”
Thiago Carvalho
boosted
RT @SocDevBio
Congrats to Anne Ephrussi @embl on receiving the 2023 @Dev_Bio_Journal-SDB Lifetime Achievement Award for her fundamental contributions to our understanding of RNA localization and translational control during development. http://bit.ly/3xtAMjM
Thiago Carvalho
boosted
Thiago Carvalho
boosted
In the context of within-host (intrahost) virus evolution, what are the best one-word terms for describing those single nucleotide variants (iSNVs) that were present in the infecting genotype, versus those derived via de novo mutation during infection? #virus #evolution
Fascinating host-manipulation story in @PLOSBiology
"Here, we characterise a plasmid translational regulator, RsmQ, capable of taking global regulatory control in Pseudomonas fluorescens and causing a behavioural switch from motile to sessile lifestyle."
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001988
"Together, our data suggest a model in which the hypodermis, a metabolic tissue, can non-autonomously regulate neuronal activity and function, indicating a systemic connection between metabolism and memory regulation."
#neuroscience #Celegans
"Preprint
Thiago Carvalho
boosted
On this day in 1971: Francis Peyton Rous died, won 1966 Nobel Prize for discovering first virus to cause cancer #NobelPrize #ThisDayInBiotech
Thiago Carvalho
boosted
Oxytocin is more than just the “love hormone” triggering prosocial behaviours, according to new research, writes @FlavorScience—it also sharpens our perception of social cues: https://t.co/CRIKBvJbSt https://t.co/tqB4OsCUae
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
