Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
This is *not* the way scientific papers typically begin:
_________________________
We are running out of time. Ecosystems across the planet are being destroyed at an accelerating rate. The life sciences – once a field dedicated to the study of living systems and our interactions with them – are increasingly becoming sciences of the dead. Up to one million species are currently threatened with extinction, many of them within decades.
_________________________
It's a very good sign, however, an indication that at least some scientists are now ready to speak boldly and unequivocally about the greatest emergency our species has ever faced.
SEE THE FULL PAPER -- https://elifesciences.org/articles/83292
If you're applying for funding via the EU Horizon program have a look at this: the European Commission has posted a list of common do's & don'ts.
"El laboratorio de David Baker en la Universidad de Washington (Estados Unidos) va un paso más allá. Ha desarrollado varios sistemas de inteligencia artificial abiertos que crean proteínas que nunca han existido en la naturaleza."
Le Floc’h et al at Regeneron generated an anti-common gamma chain monoclonal that blocks signaling.
"Treatment of nonhuman primates with REGN7257 suppressed NK cells and T cells without affecting granulocytes, erythrocytes, or platelets."
Thiago Carvalho
boosted
RT @sivajothy
The call for symposia at ICE (The International Congress of Entomology) in Kyoto 2024 is now open. ( http://shorturl.at/cxyA8 ). please retweet.
Thiago Carvalho
boosted
📢 Don't miss: Tuuli Lappalainen @tuuliel_lab (@nygenome @KTHuniversity @scilifelab) will speak at our #DahlemColloquium!
📜 Functional variation in the human #genome: lessons from the #transcriptome
📆 27. FEB, 11:00 AM (CET)
📍 @MPI_MolGen, #Berlin
🔗 https://www.molgen.mpg.de/events/33625/3967495
Thiago Carvalho
boosted
Deadline for applications to the Summer internship for INdigenous peoples in Genomics (SING) workshop to be held this year together with Diné College and Northern Arizona University is extended to February 28.
Apply here: https://singconsortium.org/
#NativesInSTEM #IndigenousSTEM #IndigenousScience #IndigenizeSTEM
Thiago Carvalho
boosted
MDPI's IJMS just sent me an email just to say they published a paper and I could read it if I wanted to. Heck, if I wanted to submit an article, they'd be pleased as punch.
I wasn't a reviewer. I had no involvement at any point. This is just spam. Specifically, it's "rent-seeking" behaviour from a publishing group nearly everyone deems "predatory."
See: bit.ly/1yrPredPub
Thiago Carvalho
boosted
Postdoctoral Research Scientist (Metagenomics) @EarlhamInst
We’re looking for a well-rounded Bioinformatician to join a collaborative research group at the Earlham Institute.
#ScienceJobs #job
Norwich #UnitedKingdomUK #Bi...
https://jobrxiv.org/job/earlham-institute-27778-postdoctoral-research-scientist-metagenomics/?feed_id=38592
Thiago Carvalho
boosted
Some objects you have to share immediately after seeing it: a Roman flask in the shape of a fish.
We don't know what flaks in the shape fishes were used for, maybe the shape relates to the content (garum/fish sauce), maybe it was used to hold oil.
On display at Pierides Museum, Larnaka, Cyprus.
Photo: Jeff Amadon via Flickr
Thiago Carvalho
boosted
Structural basis for binding of Smaug to the GPCR Smoothened and to the germline inducer Oskar
Smaug no longer desolate thanks to #StructuralBiology
#crystallography @strucbio #Science #Research
http://biorxiv.org/cgi/content/short/2023.02.19.529116v1?rss=1
Serendipity & the discovery of tyrosine kinases:
"In analysing the phosphoaminoacids released by partial acid hydrolysis of polyoma virus middle T phosphorylated in vitro, Hunter used an old batch of pH 1.9 electrophoresis buffer; it so happens that phosphothreonine and phosphotyrosine do not separate on electrophoresis at pH 1.9 in acetic acid/formic acid/water buffer, but do separate at the lower pH of ‘aged’ buffer, from which the more volatile acetic acid has escaped (T Hunter, personal communication; Ushiro and Cohen, 1980)."
Hallmarks of neurodegenerative disease
"In this review, we argue that a set of hallmarks define NDDs, namely: pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy metabolism, DNA and RNA defects, inflammation, and neuronal cell death"
"In the early 1950s, Dulbecco had been convinced by Max Delbrück, one of the founders of molecular biology, that animal viruses could be studied by the same quantitative approaches that had been used to study the replication of bacteriophages."
(From 'The Road to Src'
Thiago Carvalho
boosted
Svante Arrhenius was born #OTD in 1859. He's famous for his work on solution chemistry and his eponymous equation linking the temperature of a chemical reaction with its rate: https://www.compoundchem.com/2023/02/19/arrhenius/
"(...) but given that the Nobel Committee had a maximum of two names to award for the discovery of HIV, the choice of the 5′ and 3′ authors on the first paper (Barré-Sinoussi et al., 1983) seems just."
Thiago Carvalho
boosted
RT @grnfluoresceblg
Wow, from the abstract this paper from @Mayr_Christine lab looks super interesting!
"mRNA interactions with disordered regions control protein activity"
#mRNA #translation #mRNALocalization #ProteinStructure #RNAbinding
Thiago Carvalho
boosted
'Surprisingly, DAF-2 degradation specifically in the hypodermis improves memory in both young and aged C. elegans through the hypodermal expression of the diffusible Notch ligand, OSM-11.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
