Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'Mississippi is one of 10 states, all with Republican-led legislatures, that continue to reject federal funding to expand health insurance for the poor, intensifying financial pressure on hospitals.'

https://www.nytimes.com/2023/03/28/us/politics/mississippi-medicaid-hospitals.html

'Estas bolsas apoiam a realização de mestrado em instituições de ensino superior portuguesas para nacionais dos Países Africanos de Língua Oficial Portuguesa – Angola, Cabo Verde, Guiné-Bissau, Moçambique e São Tomé e Príncipe – nas áreas das ciências exatas (matemática, física e química) e ciências da saúde (medicina clínica).'

https://gulbenkian.pt/bolsas-lista/bolsas-de-mestrado-para-estudantes-dos-palop/

"The induction of cellular cytotoxicity requires that the NK cell contacts its target cell and establishes a lytic immunological synapse. Previous reports have revealed that membrane protrusions may be a component of immune synapses. Here, we explored whether changes in the topology of intratumoral NK cell membranes relate to the formation of lytic immunological synapses."

#Immunology #TumorImmunology

https://www.nature.com/articles/s41590-023-01462-9

" Estimates on non-adherence to treatment regimes are generally around 50% (!) for chronic illness in the US, for example, and it’s believed that poor adherence is one of the major reasons for the disparities in outcome that are seen between controlled clinical trials and real-world prescriptions."

https://www.science.org/content/blog-post/take-your-meds

'The world’s scientific publishers are becoming increasingly alarmed by the scale of fraud. An investigation last year by their joint Committee on Publication Ethics (Cope) concluded: “The submission of suspected fake research papers . . . is growing and threatens to overwhelm the editorial processes of a significant number of journals.”

https://www.ft.com/content/32440f74-7804-4637-a662-6cdc8f3fba86

'Dr. Gopnik compared the theory of mind of large language models to her own understanding of general relativity. “I have read enough to know what the words are,” she said. “But if you asked me to make a new prediction or to say what Einstein’s theory tells us about a new phenomenon, I’d be stumped because I don’t really have the theory in my head.”

https://www.nytimes.com/2023/03/27/science/ai-machine-learning-chatbots.html

Sounds familiar

"After his indictment Netanyahu became “a lot more aggressive and belligerent vis-à-vis Israel’s judiciary and law and enforcement agencies,” said Yohanan Plesner, president of the Israel Democracy Institute, a think-tank. “He also increasingly allied himself to the most marginal and extreme elements of Israeli society.”'

https://www.ft.com/content/e4524be8-c9b9-4879-8593-5d0e5543d708

"Here we show that metabolic conditioning of CD8+ effector T cells induces an oxidized cellular redox balance at least in part mediated by increased mitochondrial reactive oxygen species (ROS). This redox shift contributes to enhanced in vivo persistence and tumor clearance."

#Preprint #Immunology #metabolism #TumorImmunology

https://www.biorxiv.org/content/10.1101/2023.03.27.533229v1

The FDA is considering changes to the accelerated approval process for oncology.

"In draft guidance, the agency outlined plans to move away from single-arm studies and instead favor randomized controlled trials that can potentially serve as the basis for both accelerated and full approval."

https://www.fiercebiotech.com/biotech/fda-floats-oncology-authorization-shake-pitching-one-trial-model-accelerated-and-full