Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated glycolysis, and blockade of glycolysis by DC-specific Ldha/Ldhb double deletion resulted in defective antitumor immunity."
#Immunology #TumorImmunology #Immunotherapy #Metabolism
#InnateImmunity
'I came away from Athens struck by the sheer quantity of theatre available – this week alone there are 284 shows on offer – as well as by the quality of the acting and the capacity of the National Theatre to surmount the recent crisis. But as Moschos reminded me there is still much work to be done: the National urgently needs more money, more new writing and, not least, more female directors.'
"South Korean biotech companies are working to diversify from China in anticipation that the US could tighten export restrictions on the sector to bolster its domestic industry and curb Chinese growth."
https://www.ft.com/content/49870c62-4be2-453b-a93d-fe8cb59bdd35
Thiago Carvalho
boosted
Accidental science art: witness the pixel value difference between two different non-linear transformations of the same image, one where the image used for computing the deformation field with a thin-plate spline was filtered with a Gaussian and another with a bandpass filter – two different approaches to mitigate an invariant grid pattern that would foul the image registration.
Licence: CC-BY
Thiago Carvalho
boosted
“Drenched in British purples, I have offered up my tones: pigeon breast, hind belly, balky mule lung, monkey bottom pink, lapis lazuli and malachite, excited nymph thigh, panther pee-pee, high-smelling hen hair, hedgehog in aspic, barrel-maker’s brothel, revered rose, monkeybush, turkey-like white, sly violet, page’s slipper, immaculate nun spring, unspeakable red, Ensor azure, affected yellow, mummy skull, rock-hard gray, brunt celadon, shop soiled smoke ring.”
James Ensor
'But increasingly the American mortality anomaly, which is still growing, is explained not by the middle-aged or elderly but by the deaths of children and teenagers. One in 25 American 5-year-olds now won’t live to see 40, a death rate about four times as high as in other wealthy nations.'
https://www.nytimes.com/2023/04/06/opinion/deaths-life-expectancy-guns-children.html
" Treatment of nasal cultures with type 2 cytokine IL-13 to mimic asthmatic airways differentially impacts HCoV receptor availability as well as replication. MERS-CoV receptor DPP4 expression increases with IL-13 treatment, whereas ACE2, the receptor used by SARS-CoV-2 and HCoV-NL63, is down-regulated. IL-13 treatment enhances MERS-CoV and HCoV-229E replication but reduces that of SARS-CoV-2 and HCoV-NL63, reflecting the impact of IL-13 on HCoV receptor availability."
Thiago Carvalho
boosted
JOB ALERT: The Marseille Rare Disease University institute is hiring a Junior Professor Chair to conduct a research program aimed at developing innovative cellular models in the field of rare diseases. It's a tenure-track position with 200K in startup funds and a teaching program you can shape a lot as it's in its infancy. Your research colleagues would be here: https://www.marseille-medical-genetics.org/. Teaching can be in English (administrators are French) but great students! Contact me for more info.
'We reveal that tonic IFN-I expression characterizes osteoclast precursors prior to receptor activator of NF-kappaB ligand (RANKL) exposure and that many tonic ISGs are repressed by RANKL signaling. In addition, the ISG response to RANKL is complex and multifaceted.'
'But the rise of microtargeting has come with a staggering price tag. “There is limited evidence to suggest that the efficiency and efficacy gains to advertisers and publishers of this system outweighs the societal impact,” concludes a 274-page study published by the European Commission this year. It calls for reforming the surveillance business model.'
'“Success would be … if not exponential, at least some logarithmic progression towards more and more gene therapies being approved,” he said. The agency has approved 12 gene therapies to date, according to Marks, five of which came in 2022.
To get there, Marks and CBER have a four-poin plant: improve manufacturing through new research, clarify the use of the accelerated approval pathway for gene therapies, coordinate regulatory decisions with other regulators and launch an Operation Warp Speed for rare diseases. Easy, right?'
Thiago Carvalho
boosted
How did #COVID19 affect the seasonality of other respiratory viruses?
It is widely known that what we call the "flu season" results from several different viruses including #influenza #RSV #corona ...
These mostly infect(ed) during the winter but the pandemic seriously disrupted their dynamics:
1) During the lockdowns/stringent NPIs they basically disappeared
2) When the measures were loosened, the viruses re-appeared off-season (surges in spring, summer, fall)
https://www.medrxiv.org/content/10.1101/2023.03.28.23287799v1
Thiago Carvalho
boosted
DYK fake news spreads faster and further than real news? Joana Gonçalves de Sá @SpacLab is using #datascience and #behaviouralpsychology to understand why some people are more likely to share #disinformation.
@mjoanasa #InternationalFactCheckingDay
🐦🔗: https://n.respublicae.eu/ERC_Research/status/1642436762034401285
Thiago Carvalho
boosted
"O que é que é normal?", pergunta Joana Sá (@joanagsa).
"Este texto é sobre #normalidade, normalidade estatística e #normatividade. Vem a propósito do dia internacional da #mulher e das acusações de radicalismo que tendo a sofrer nesta altura por defender a #igualdade. Tentarei argumentar que conceitos simples de estatística são úteis para compreender que a normatividade não é “natural”.
E passa a explicar:
https://almanaquemag.com/o-que-e-que-e-normal/
🎨 #JoanaSá
Thiago Carvalho
boosted
ICYMI, the UK Reproducibility Network (UKRN) has issued a call for feedback to help formulate robust indicators of open research. Details are below. It's a problemtic area that requires as much participation as possible.
Indicators of Open Research: UKRN call for priorities https://www.ukrn.org/2023/03/15/or-indicators-call-mar23/ #OpenResearch #UKRN #OpenScience
Thiago Carvalho
boosted
Welcome @jomcinerney to Mastodon #MolecularEvolution #ecoevo
Thiago Carvalho
boosted
Antigen independent metabolic effects of CAR constructs:
"Here we show that CARs differing only in the scFv reprogram T-cell metabolism differently. Even in the absence of antigens, some CARs increase proliferation and nutrient uptake in T cells."
#immunology #Preprint #Immunotherapy #CARTcells
Thiago Carvalho
boosted
"Clarifying how the pandemic genome first came to the world’s attention is important not just for the sake of record-keeping: if science forgets how fraught and politically messy data-sharing became, it may not learn lessons from that process."
https://www.ft.com/content/18a643df-a1d8-41bb-acd0-46d2c768bd40
Thiago Carvalho
boosted
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
