Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'But increasingly the American mortality anomaly, which is still growing, is explained not by the middle-aged or elderly but by the deaths of children and teenagers. One in 25 American 5-year-olds now won’t live to see 40, a death rate about four times as high as in other wealthy nations.'

https://www.nytimes.com/2023/04/06/opinion/deaths-life-expectancy-guns-children.html

TRIM21 is a fascinating molecule - it's basically an intracellular Fc receptor. Here, Mukadam et al show that it plays a role in antibody mediated prevention of tau protein aggregate formation in neurone.

https://www.science.org/doi/10.1126/science.abn1366

The jump to MHC alleles without described ligands is a promising sign that MixMHC2pred-2.0 could be a powerful tool for both basic and clinical research. Very curious to see if other groups validate and adopt it.

"Within humans, our work revealed that MHC-II binding motifs and MHC-II ligands could be accurately predicted even for alleles without known ligands. This is an important improvement of MixMHC2pred-2.0 compared with MixMHC2pred-1.2 and NeonMHC2, which were not applicable to most patients and could not be included in our benchmarks."
#Immunology

https://www.sciencedirect.com/science/article/pii/S1074761323001292?dgcid=coauthor#sec4

Frustrated phagocytosis is such an excellent term

Rapid redistribution of clathrin onto macrophage plasma membranes in response to Fc receptor-ligand interaction during frustrated phagocytosis. https://rupress.org/jcb/article-abstract/102/1/55/13322/Rapid-redistribution-of-clathrin-onto-macrophage/

Significant detail regarding #ClarenceThomas failure to disclose multiple gifts of travel from Harlan Crow over the years. In 2004, the LA Times reported on gifts Thomas disclosed he had received from Crow. After this reporting, Thomas didn’t stop accepting gifts from Crow; he just stopped disclosing them. https://www.latimes.com/politics/story/2023-04-06/the-times-reported-about-justice-thomas-gifts-20-years-ago-after-he-just-stopped-disclosing-them #JudicialEthics

We provide sample datasets for microbiology- or developmental biology-centered courses. You can use our cartoons or draw your own for your discipline 3/

Students receive figures with cartoon datasets. They interpret the results, decide on figure order, make a model figure, then write a manuscript explaining the findings. Peer review steps included! 2/

Teaching students to interpret data and write their first scientific paper can be hard!
Our new publication provides all the materials you need to teach these skills in graduate or upper-level undergraduate courses. 1/
https://doi.org/10.24918/cs.2023.14

Eadweard J. Muybridge, Untitled (Landscape near Watsonville, California), c. 1879

NPR has not tweeted since Musk put a “state media” tag on their account on April 5.

#Twitter #NPR