Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
#DukeBrainJobs in neural engineering. Interested? Learn more n' apply below!
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RT @NikkiPelot
We are #hiring!
Have you heard that we're building some pretty epic computational models of neural stimulation to treat diseases?
Do you know anyone who might be interested in joining our team?
Apply here! https://academicjobsonline.org/ajo/jobs/24760
Please share!
https://twitter.com/NikkiPelot/status/1651753269931171846
Thiago Carvalho
boosted
A banca vai distribuir 1150 milhões pelos seus acionistas. Um resultado extraordinário construído em cima das dificuldades de quem vive do seu trabalho e de um Governo que preside a uma das maiores transferências de rendimento do trabalho para o capital de sempre.
🐦🔗: https://n.respublicae.eu/joseggusmao/status/1654467587483287555
Thiago Carvalho
boosted
RT @PessoaBrain
𝗕𝗿𝗶𝗱𝗴𝗶𝗻𝗴 𝗹𝗲𝘃𝗲𝗹𝘀 𝗮𝗻𝗱 𝗺𝗼𝗱𝗲𝗹 𝘀𝘆𝘀𝘁𝗲𝗺𝘀 𝗶𝗻 𝗻𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲: 𝗖𝗵𝗮𝗹𝗹𝗲𝗻𝗴𝗲𝘀 𝗮𝗻𝗱 𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝘀
(via @MillerLabMIT)
https://onlinelibrary.wiley.com/doi/10.1111/ejn.15990
"Covid was the fourth leading cause of death in the United States last year, dropping from its place as the third leading cause in 2020 and 2021, when virus fatalities were superseded only by heart disease and cancer, the National Center for Health Statistics reported on Thursday."
https://www.nytimes.com/2023/05/04/health/covid-deaths-2022.html
'A similar percentage of deaths from the same side effect followed in the clinical trial of Leqembi, an F.D.A.-approved Alzheimer’s drug from the company Eisai. A third drug, Aduhelm, was also approved by the F.D.A., but is rarely used because of concerns about its effectiveness and its high price. Brain swelling was reported in its clinical trial and deaths were reported in patients taking Aduhelm after it was approved.'
https://www.nytimes.com/2023/05/03/health/alzheimers-drug-eli-lilly-trial.html
'GSDM (the gene encoding gasdermin) and GSDM-like genes are evolutionarily ancient and have been identified across a wide range of animal and nonanimal species, including fungi and bacteria.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002103
Thiago Carvalho
boosted
#UExM
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RT @embl
EMBL’s Dey group embarked on 2nd annual ‘labbatical’ to step outside daily research tasks w/ help of single-celled model organisms.
The group applied its usual high-tech tools and world-class expertise, but with a totally different model organism.
https://www.embl.org/news/lab-matters/the-hairy-single-celled-tetrahymena-provides-a-work-reset/
https://twitter.com/embl/status/1654403181441347584
'The European People’s party, which has the most seats in the European parliament and is in power in nine countries across the EU, will call on Friday to scrap two flagship pieces of legislation put forward by their own European Commission president, Ursula von der Leyen. The move could torpedo the commission’s plans to cut pesticide use in half and rewild a fifth of damaged habitats across the bloc by 2030.'
https://www.ft.com/content/38f5801e-a68c-4328-b467-a07ee7fbd94d
'Why was the Celera compound initially neglected? Because it was only years later that researchers at the US government’s National Institutes of Health (NIH) showed that overactive BTK drove the growth of CLL and certain lymphomas, so blocking it would inhibit these cancers. When Celera sold it to Pharmacyclics, it didn’t have any apparent application.'
Thiago Carvalho
boosted
Transforming tuberculosis diagnosis - Nature Microbiology
#tuberculosis #MedMastodon #medicine #tb #diagnostics #diagnosis
'These distinct roles for EZH2 in promoting prostate cancer progression, metastasis, and AR independence raise the possibility that it could be a potential therapeutic target in advanced disease.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002038
Thiago Carvalho
boosted
We also have serial PCR evaluations showing that individuals who get HPV vaccines prevent HPV infections (or at least promote rapid clearance of the virus) which is a prerequisite for developing cancer:
https://academic.oup.com/jid/article/221/6/910/5648192
Thiago Carvalho
boosted
For our lab's weekly journal club covering classic papers in immunology, we discussed Zheng and Flavell's discovery of GATA3 as a critical transcription factor for Th2 cell cytokine expression.
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells. Cell, 1997.
Before microarray or RNA-seq, there was cDNA subtraction by representational difference analysis.
https://www.cell.com/action/showPdf?pii=S0092-8674%2800%2980240-8
Thiago Carvalho
boosted
Rifamycin based TB preventative therapy associated with less adverse events.
#IDMastodon #MedMastodon #TB #tuberculosis #antibiotics
'Britain’s biggest biomedical charity is to triple the size of its genetics and biological data facilities near Cambridge, in one of the largest investments in UK research infrastructure'
https://www.ft.com/content/b2d3f6a8-7e1f-48f3-a298-6588c56d91bc
Thiago Carvalho
boosted
#Gasdermins (GSDMs) are pore-forming proteins involved in #CellDeath & #inflammation. @jianbin_ruan explores a #PLOSBiology study of the evolution of GSDMs in metazoa, highlighting the role of GSDME in #pyroptosis. Primer: https://plos.io/3nyd4By Paper: https://plos.io/3p6klcm
Thiago Carvalho
boosted
RT @gyamey
A friend died from anal cancer, which could have been prevented with HPV vaccination, & I am tired of the “edgy” health professionals on Twitter who advise people to “exercise, sleep & eat good food” instead of getting HPV vaccination
Actually, not just tired, kinda angry
Thiago Carvalho
boosted
BREAKING: Leonard Leo (Federalist Society) paid tens of thousands of dollars to Ginni Thomas and omitted her name from the billings. https://www.washingtonpost.com/investigations/2023/05/04/leonard-leo-clarence-ginni-thomas-conway/
Thiago Carvalho
boosted
The cilium–centrosome axis in coupling cell cycle exit and cell fate
In their Opinion article, @priti_atmakuru and Jyotsna Dhawan discuss the role of the cilium-centrosome complex in tissue homeostasis.
Thiago Carvalho
boosted
Focussing on the past, the present and the future
Check out the latest in all things FocalPlane in our Editorial from @helenzsci and @seemasainson published in @J_Cell_Sci!
We look back over the three years since FocalPlane was launched and look forward to some exciting projects in 2023 and beyond, including working with our #FocalPlaneCorrespondents.
https://focalplane.biologists.com/2023/05/03/focussing-on-the-past-the-present-and-the-future/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
