Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Their work paved the way for companies such as GSK, Pfizer and Moderna to develop the RSV vaccines in the pipeline today. “This is my lifetime's work. It’s very gratifying to see this finally happening,” Graham says. “It’s a good day for RSV.”
I wrote about RSV vaccines in my #NatureMedicine column in February.
Very good news this week with the FDA approval of GSK's RSV vaccine for adults 60 and over - it's the first approved RSV vaccine.
https://edition.cnn.com/2023/05/03/health/first-rsv-vaccine-approved/index.html
Several other candidate RSV vaccines are at a late stage of development, including mRNA based vaccines. The next big thing to watch for are those seeking to protect newborns and infants by maternal immunisation.
#RSV #Vaccine #RespiratoryVirus #drugdevelopment #Pharma #Immunology
Thiago Carvalho
boosted
'GSDM (the gene encoding gasdermin) and GSDM-like genes are evolutionarily ancient and have been identified across a wide range of animal and nonanimal species, including fungi and bacteria.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002103
Thiago Carvalho
boosted
'A similar percentage of deaths from the same side effect followed in the clinical trial of Leqembi, an F.D.A.-approved Alzheimer’s drug from the company Eisai. A third drug, Aduhelm, was also approved by the F.D.A., but is rarely used because of concerns about its effectiveness and its high price. Brain swelling was reported in its clinical trial and deaths were reported in patients taking Aduhelm after it was approved.'
https://www.nytimes.com/2023/05/03/health/alzheimers-drug-eli-lilly-trial.html
From Oliver Sacks, "River of Consciousness".
#Books #Bookshelf #BookClub #consciousness #SciComm #readerlife #bookstodon
Thiago Carvalho
boosted
Post-doctoral position - Oligodendroglial cells - Moyon lab @inp @NeuroSarah
Looking for a postdoctoral fellow to join a new neuroscience lab
#ScienceJobs #job @inp_marseille
Marseille #France #PostdoctoralFellow
https://jobrxiv.org/job/institute-of-neurophysiopathology-27778-post-doctoral-position-oligodendroglial-cells-moyon-lab-inp/?feed_id=44672
Thiago Carvalho
boosted
Remembering the one and only George Orson Welles (1915-85), the mercurial, Oscar / Grammy-winning film, radio and theatre actor, writer, producer and director, born in Wisconsin on this day. Pictured here, with Edward G. Robinson and Loretta Young, in his third film as director, the stunning noir The Stranger (1946).
#OrsonWelles #Actor #Director #MercuryTheatre #GoldenEraHollywood #ClassicHollywood #FilmNoir #BornOnThisDay #BOTD #OTD #OnThisDay
Herd- or group-think in drug development:
"Large companies are the biggest contributors to this phenomenon, with an estimated 68% of the portfolios of the top 10 companies going after targets with a significant amount of herding. And one of the reasons mentioned for this is the increasing number of combination therapies (especially in oncology), where organizations want their own drug candidates in that mix, rather than relying on having their new drug dosed with somebody else’s."
'Soon, telomeres were hailed as a secret to aging — companies advertised that they could tell your biological age by measuring the length of your telomeres. Others said that you could extend your life by preserving your telomeres with supplements.
But Dr. Armanios and other researchers had noticed that telomere lengths seemed constrained to a narrow range, indicating there is a price to pay for very long or very short telomeres.'
https://www.nytimes.com/2023/05/04/health/long-telomeres-age-longevity.html
Thiago Carvalho
boosted
The birth of molecular oxygen in Photosystem II!
Wonderful work from our institute, my colleagues Athina Zouni, Holger Dobbek (and friends!) in the Leonor Michaelis Haus.
Still astounding to me that for PSII, the O2 is a waste product! It only wants the electrons...
'In Japanese, human survivors of the atom bomb are called hibakusha. These surviving trees have a name as well: hibakujumoku.'
https://www.nytimes.com/2023/05/05/opinion/hiroshima-japan-trees.html
Thiago Carvalho
boosted
"Covid was the fourth leading cause of death in the United States last year, dropping from its place as the third leading cause in 2020 and 2021, when virus fatalities were superseded only by heart disease and cancer, the National Center for Health Statistics reported on Thursday."
https://www.nytimes.com/2023/05/04/health/covid-deaths-2022.html
Thiago Carvalho
boosted
'But Eli Lilly’s preliminary donanemab results also reveal a sobering risk of brain swelling and hemorrhaging, side effects that the company disclosed may be linked to two—perhaps three—deaths in the clinical trial and that echo hazards seen with lecanemab, which is being marketed by Eisai and Biogen.'
Thiago Carvalho
boosted
How do tumors promote #hematopoiesis outside the #BoneMarrow? @TheKingLab explores a new #PLOSBiology study of the mechanisms, which may hold the key to disrupting #immunosuppressive #tumor microenvironments. Primer: https://plos.io/3AYeiZY Paper: https://plos.io/41jMOJb
Thiago Carvalho
boosted
Postdoc in genomic recording, epigenomics, and cell fate (Kalhor Lab) @kalhorlab
Postdoc positions in Synthetic Biology, Genomics, and Developmental Biology
for candidates with experience in Synbio, Omics, Devbio, or related fields
What a great cover.
From the NYT obit for artist Bruce McCall
Thiago Carvalho
boosted
If you have a billion dollars, covering a $6,000-a-month tuition is the same relative cost as someone with $60,000 being asked to pay 36 cents.
If you could earn the close friendship of a Supreme Justice for 36 cents a month, wouldn't you?
https://www.washingtonpost.com/politics/2023/05/04/clarence-thomas-supreme-court-harlan-crow/
Thiago Carvalho
boosted
Hey #Drosophila folks: EDRC early bird registration deadline is coming up (May 15th)! Register now to get early bird pricing! And maybe I'm biased, but looking forward to some great immunology-related submissions 😛
Thiago Carvalho
boosted
RT @HarmitMalik
Every student in molecular biology should learn about Hal and just the remarkable science and spirit of science that still shapes the @HutchBasicSci division @fredhutch even today. Here is one article that captures his uniqueness: https://www.fredhutch.org/en/news/center-news/2015/04/remembering-harold-weintraub-20-years-later.html
Thiago Carvalho
boosted
Good stuff from The Onion but I straight up heard this talk from some evolutionarily psychologist in around 2004.
https://www.theonion.com/anthropological-research-reveals-ancient-cultures-used-1850387152
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
