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'Daily oral orforglipron, a nonpeptide GLP-1 receptor agonist, was associated with weight reduction. Adverse events reported with orforglipron were similar to those with injectable GLP-1 receptor agonists.'

nejm.org/doi/full/10.1056/NEJM

"Corless is the local historian who a decade ago alerted Ireland, and the world, to a shocking truth about this Galway town: for decades an institution for unmarried mothers put the remains of dead babies and children in a disused subterranean septic tank."

theguardian.com/world/2023/jun

Water companies paid out more than £50bn in dividends to shareholders in the last 30 years. Thames Water is now £14bn in debt and the Government will probably have to bail them out.
Even then they’ll refuse to take the company back into public ownership and will basically give it back to their friends after paying off the debt.
And there’s billions that still needs investing in the water infrastructure itself.
Who ever thought privatising water monopolies was a good idea?

Me in 1994: I'm gonna be a physicist so I can solve the secrets of the universe!

Me in 2023: I'm gonna have to spend time online explaining to weirdos that vaccines don't make you magnetic

The key words here are "locally acquired".

'In the last two months, at least five people, four in Florida and one in Texas, have been infected with malaria in the United States, the Centers for Disease Control and Prevention said in a health advisory on Monday. These are the first known cases of locally acquired malaria in the country since 2003.'

nytimes.com/2023/06/27/health/

Os colegas do Montenegro

'Segundo o relatório, o partido “tem trabalhado para envenenar o discurso nacional com retórica racista, anti-LGBTQ+, anti-imigração e anticigana". Estou convicta de que os portugueses - os que não estão envenenados – não precisariam de que uma organização estrangeira viesse clarificar que é de cariz racista a retórica do Chega.'

publico.pt/2023/06/28/opiniao/

New TG mouse model for infection

"In this study, we report an inducible, transgenic hACE2 mouse line and showcase three examples for specifically expressing hACE2 in three different lung epithelial cells, including AT2 cells, club cells, and ciliated cells. Moreover, all these mice models develop severe pneumonia after SARS-CoV-2 infection."

pnas.org/doi/10.1073/pnas.2207

#Introduction

I am a #NewPI in stem cell & developed tan biology working at the Babraham Institute (Cambridge).
Will tweet about everything related with #devbio and life as an academic scientist.

Very excited that a community is built!

The current structure of science funding would make Max Perutz's work impossible and Perutz unemployed:

"Max, inspired by Bernal's vision that the structure of large and complex molecules such as proteins could be solved using X-ray diffraction, embarked on scaling a mountain in biology—solving the structure of haemoglobin. This was to take him more than 20 years."

embopress.org/doi/full/10.1093

Last few days to check out "Oubliette", a collective show by
@anaanajottajotta @consta_arouca @jorgenesbitt @madparreira at Biblioteca Camoes, Lisbon.

and more.

informacoeseservicos.lisboa.pt

Another famous passage from Dale. The ripple and shimmer!

"If 1 gamma of acetylcholine, for example, dissolved in 0.1 cc of Ringer’s solution, is thus injected suddenly into the artery supplying the frog’s gastrocnemius, the surface of the muscle, covered with its glistening aponeurosis, shows immediately the ripple and shimmer of innumerable, unsynchronized contractions, propagated along the fibres and fascicles of the muscle"

nobelprize.org/prizes/medicine

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Opinion in #TheGuardian : The #car is king in the #US – and #pedestrian deaths are rising. Where is the outrage?

"Pedestrian deaths are at a 40-year high and the number of #cyclists hit by #cars has increased since the pandemic. The most astounding part? These are preventable tragedies" writes Arwa Mahdawi

#cycling #walking #roadSafety

In flies:

"Using a transcriptomic analysis of over 37,000 nuclei, we identified twelve distinct clusters of cells corresponding to temperature-sensing arista neurons, humidity-sensing sacculus neurons, and support cells relating to these neurons."

biorxiv.org/content/10.1101/20

'Era una mujer sin nombre, de pie sobre una barricada en la Barcelona de 1936, una bandera rojinegra detrás. La imagen se imprimió en carteles y libros, se pintaron murales, y ella se convirtió en un icono de la Guerra Civil. Se desconocía su identidad. Y la del fotógrafo.'

elpais.com/cultura/2023-06-27/

#IDMastodon #Viralimmunology #Immunology #Cytokinebiology @CytokineSociety The delicate balance of the pro- & anti-inflammatory #cytokine responses that mediate effective clearance of viral titters is crucial for the effective resolution of #COVID19.
#Cytokinestorm results from disrupting this equilibrium, leading to uncontrolled immune cell responses.

'The Metropolitan police have admitted downloading the sim card from the phone of a radical French publisher who was arrested by counter-terrorism police at St Pancras station in April, his lawyer has claimed.

Officers returned the iPhone and laptop it had seized from Ernest Moret, 28, to his London lawyer on Tuesday after the Met announced late on Friday that no further action would be taken against him. He had been arrested on his way to the London book fair and held for almost 24 hours under schedule 7 of the Terrorism Act 2000.'

theguardian.com/uk-news/2023/j

RT @wrkclasshistory@twitter.com

#OtD 27 Jun 1869 Emma Goldman, the legendary Jewish writer, feminist, birth control advocate, and anarchist was born in what is now Lithuania. Some of her works, and items celebrating her life available here to help fund our work: shop.workingclasshistory.com/c

🐦🔗: twitter.com/wrkclasshistory/st

RFI: "Needs and Challenges in Obtaining and Testing Clinical-Grade RNA-based Cancer Vaccine Formulations to Support Translational and Clinical Research"

grants.nih.gov/grants/guide/no

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