Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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@cyrilpedia @MarkHanson I usually discuss it my genomics class after I introduce junk DNA just to emphasize all the raw material available for evolution.
Thiago Carvalho
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Alito is being paid to recreate the 19th century on behalf of Republican billionaire donors.
Slavery. Disenfranchisement. Robber barons & aristocracy controling everything.
No taxes on the rich. Public corruption. Patriarchy. Jim Crow. Nazis. Two tier justice. Civil rights rollbacks.
Women dying in childbirth leaving 11 orphans. Pollution. Disease. Contaminated air & water. Theft of tribal lands. Poverty. Tenements. Children in coal mines.
Thiago Carvalho
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#Profiteering
The Guardian view on pricing power: it’s about firms’ strength and profiteering
https://www.theguardian.com/commentisfree/2023/jun/27/the-guardian-view-on-pricing-power-its-about-firms-strength-and-profiteering?CMP=Share_AndroidApp_Other
Thiago Carvalho
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Expand your connections at the hybrid networking event of the LMU Open Science Summer School. Engage in speed networking discussions and exchange your ideas whether you're attending in person or joining virtually.
Apply before July 17!
https://malikaihle.github.io/OSC-Open-Research-Summer-School-2023/
Thiago Carvalho
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Now out in @PLOSBiology - "A biologist’s guide to planning and performing quantitative bioimaging experiments"! Check out our getting-started guide designed to help you learn what you'll need to learn, as well as the interactive version at bioimagingguide.org. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002167 1/2
The spandrels essay always resurfaces
'A germline-encoded specificity might have arisen as an evolutionary spandrel, a byproduct of immunoglobulin gene diversification in vertebrates, and then been selected (Gould and Lewontin, 1979; Sangesland and Lingwood, 2021; Pennell et al., 2023). For instance, germline alleles with innately high affinity for bacterial antigens might be favored if they protect against commonly encountered pathogens and commensals via broad classes of epitopes shared by these organisms (Yeung et al., 2016; Collins and Jackson, 2018; Sangesland et al., 2020).'
Thiago Carvalho
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@voron @mariyadelano @thomholwerda @Yup_Its_Holly
We are overlooking how the negativity of social media is funded. Targeted harassment campaigns are funded. Malign influence campaigns aren't organic or natural
Troll farms like Prigozhin's don't come cheap. Larry Elliison and Google are opening new "data centers" in Saudi Arabia for a reason
https://www.axios.com/2022/07/29/doj-russian-inductment-kremlin-influence-campaign
There's a semi-orchestrated effort to drive prominent women and POC off social media for political gain
https://theintercept.com/2023/05/05/foreign-malign-influence-center-disinformation/
Thiago Carvalho
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They were here indeed .
A great week teaching MD PhD students of the multi-institutional EMERALD MD PhD program for the second year, this time at the Instituto Gulbenkian de Ciencia in Lisbon (last year at Centre for Genomic Regulation (CRG) Barcelona). Thanks to David Brena, PhD, Damjana Kastelic, Luis Moita, Gabriel G. Martins, Tiago Paixao & Ricardo Leite for making it all happen.
The first part was a one day workshop on modern scientific publication that David del Álamo and I designed. The rest was discussing the interplay of basic science and medical progress with a wonderful group of students.
Thiago Carvalho
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Regulation of #LRRK2 mRNA stability by ATIC and its substrate #AICAR through ARE-mediated mRNA decay in #Parkinson's disease
Yulan Xiong and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022113410
Warm-blooded mega sharks
"To address these uncertainties, we present unique geochemical evidence for thermoregulation in O. megalodon from both clumped isotope paleothermometry and phosphate oxygen isotopes. Our results show that O. megalodon had an overall warmer body temperature compared with its ambient environment and other coexisting shark species, providing quantitative and experimental support for recent biophysical modeling studies that suggest endothermy was one of the key drivers for gigantism in O. megalodon and other lamniform sharks."
Thiago Carvalho
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Alito bought the Catholic church a pass on federal lawsuits on child sex abuse and domestic abuse. Ditto the Southern Baptist Convention & Mormons & Tech.
https://gizmodo.com/reddit-scotus-declines-child-sex-abuse-case-section-230-1850488651
Yes, the "family values" party thwarts RICO prosecution of mass child abuse cover ups by organizations.
The only ideology followed by the GOP is "The Golden Rule: Whomever has the gold, makes the rules."
"Might makes Right" fascism
Thiago Carvalho
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In their JEB100 Editorial Craig Franklin & Pat Wright introduce the Perspective by CoenHird & co discussing Indigenous insights and providing questions for comparative physiologists to consider
https://journals.biologists.com/jeb/article/226/12/jeb246317/319903
"Here, we performed an extensive profiling of systemic myeloid cell populations and plasma soluble factors in NSCLC patients undergoing PD-L1/PD-1 blockade therapies, before and during treatment. Responder patients showed an elevated diversity of myeloid cell types, enriched in activated monocytic cells, and decreased granulocytic populations. Plasma FKN concentration correlated with myeloid cell diversity and response to PD-L1/PD-1 blockade."
Bocanegra et al @emboreports
#Immunology #immunotherapy
"There’s an old adage that to write a good novel, you should write a complete draft, put it in a drawer, then forget about it and start work on what will become the real book. Nonfiction is similar. Writing takes a huge amount of practice, which means it’s a good idea to first build up a portfolio of articles, stories, and blog posts."
I love Current Biology - probably my favorite journal ever since I haunted the university library waiting for each new issue to read Sidney Brenner's Loose Ends. But maybe "Free Vaginas" is not the best layout option for their webpage.
Thiago Carvalho
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Correlated Protein Modules Revealing Functional Coordination of Interacting Proteins Are Detected by Single-Cell Proteomics | https://pubs.acs.org/doi/10.1021/acs.jpcb.3c00014 #proteomics
"Because Proteromonas is a member of the sister lineage to Blastocystis, structurally a more typical stramenopile, and yet is also a member of the anoxic animal intestinal microbiome, we have investigated the genome and cell biology of P. lacertae to better understand the reductive evolution and genomic peculiarities accompanying the transformation of Blastocystis into the highly divergent but dominant member of the protistan community in the human and animal gut #microbiome today."
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00620-6
Thiago Carvalho
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Hi everyone. We’re #Co_Biologists, a not-for-profit #publisher dedicated to inspiring the #biology community:
- We publish five #journals: @Dev_journal @J_Cell_Sci @J_Exp_Biol @DMM_Journal & @BiologyOpen
- We facilitate scientific #meetings & provide #grants for #researchers
- We run three #community sites: @the_node @preLights @focalplane_jcs
- We are committed to #OpenAccess
- We have initiatives to support early-career researchers #ECRs
Last two days to check out "Oubliette", a collective show by
@anaanajottajotta @consta_arouca @jorgenesbitt @madparreira at Biblioteca Camoes, Lisbon.
#Art #exhibition #artgallery
#sculpture #printmaking and more.
Thiago Carvalho
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... then it was the MHC, and then they came for CD38. Neuroscientists are pillaging the immune system for molecules again :)
Astrocyte CD38, neuronal circuit formation & social behavior in adults. Hattori et al @embojournal
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
