Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
'Mavericks, also known as Polintons, are unique because they share features of both transposons and viruses. Like transposons, Mavericks are flanked by terminal inverted repeats and can readily jump and insert into genomes. Like viruses, they code for a large number of proteins, including a type-B DNA polymerase, a retroviral-like integrase, as well as major and minor capsid proteins'
Thiago Carvalho
boosted
Big Journalism's abject capitulation to Musk, despite his loathing of their work and promotion of democracy's enemies, will not change unless he makes Twitter unusable.
Given the latest fail, perhaps practicality will prevail over honor.
But this would require work on the part of journalists and their employers. They may consider that to be an insurmountable barrier.
This is not good.
"Changes to the primary end point during or after recruitment were omnipresent in randomized clinical trials with immune checkpoint inhibitors for patients with UC, RCC, and NSCLC. Most common were switching to or adding OS as an outcome measure and subpopulations based on PD-L1 expression. Ultimately, published data often do not allow readers to infer what the results would have been if the primary outcome had not been changed."
#Immunology #Immunotherapy #immunooncology #checkpointinhibitors
Thiago Carvalho
boosted
My take on the importance of igniting curiosity to fight #disinformation.
#teaching #education #medicine #universities #FactsMatter #scicomm
#misinformation #Canada #USA #academia #Science
https://www.universityaffairs.ca/opinion/in-my-opinion/the-importance-of-curiosity/
Thiago Carvalho
boosted
Instead of the classic smell of burning wood in a fireplace or campfire, things are starting to smell more like burned plastic so what is going on? It turns out that when smoke stays in the air for prolonged periods of time, the UV radiation from the sun interacts with all the volatile organic compounds (VOCs) to form even more toxic gases. 3/
Thiago Carvalho
boosted
Ecological associations among gut bacteria are largely consistent across hosts in a population of wild baboons. https://elifesciences.org/articles/89468?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights
'To address the gap, the FAIRplus consortium – a unique initiative that brought together partners from academia, including EMBL-EBI, and major pharmaceutical companies – launched a new FAIR Cookbook and FAIRification framework, supporting organisations and projects undertaking a FAIR transformation.'
Thiago Carvalho
boosted
Politics
Thank goodness #university tuition is free in #Scotland. The #Tories are engaged in class war, now showing their contempt for #students who don’t vote #Tory.
Rishi Sunak told meeting he’d 'get tough on universities full of non-Tory voters' https://www.mirror.co.uk/news/politics/rishi-sunak-told-meeting-hed-30370275
Thiago Carvalho
boosted
Identification of the bacteriophage nucleus protein interaction network | bioRxiv
Thiago Carvalho
boosted
I haven’t been that active on the main timeline here, so a bit of an update on where I am at the moment: I’ve joined up with a partner and we are working towards a bigger company than just me, myself and I. The product of the company will be accurate anatomical models of animals. With the emphasis on accurate. At first mainly the animals used in biology education and later maybe other animals. We are teaming up with several scientists, in the Netherlands, Germany and more. 1/2
Thiago Carvalho
boosted
@cyrilpedia
Notwithstanding the caveats of mouse #TB models, that looks worth a read especially as it embraces heterogeneity of responses and outcomes.
Also, a new hashtag i should use more often! 😉 #hostpathogen
Thiago Carvalho
boosted
Paul McDonough, New York, 1968 -1978
https://www.lensculture.com/books/7281-paul-mcdonough-new-york-photographs-1968-1978
Thiago Carvalho
boosted
#Sunak U-turn on #WindFarms in #England draws wrath of green #Tories | #Wind{ower | The Guardian
With one or two exceptions, the #Tories have no interest in tackling #GlobalWarming.
#Environment #RenewableEnergy #Renewables #ClimateChange #RishiSunak
O sonho da IL
"Another busy week for Britain’s Ministry of Metaphor, as the country’s largest supplier of that luxury product “water” teeters on the brink of collapse."
'Tuberculosis (TB) is a heterogenous disease in humans with individuals exhibiting a wide range of susceptibility. This heterogeneity is not captured by standard laboratory mouse lines. We used a new collection of 19 wild-derived inbred mouse lines collected from diverse geographic sites to identify novel phenotypes during Mycobacterium tuberculosis (Mtb) infection.'
#Preprint #Tuberculosis #Immunology #HostPathogen #InfectiousDisease
'São cerca de 52 mil estudantes com prestações atrasadas, dos quais quase 6000 já têm os seus processos entregues à Autoridade Tributária para cobrança coerciva.'
'In an uncanny anticipation of his subsequent reception history, Johannes Vermeer made one of his first appearances in the printed record in the guise of a phoenix, the mythical bird that regenerates itself from its own ashes.'
https://www.nybooks.com/articles/2023/07/20/life-made-light-johannes-vermeer/
Thiago Carvalho
boosted
Twitter, once the most powerful real-time information system ever built, so much so someone accidentally live tweeted the death of bin Laden, now not only can’t be used to save lives from bad weather, but won’t even let the existence of bad weather be seen by the weather people.
'In patients with resectable stage IIIA or IIIB NSCLC, perioperative treatment with nivolumab plus chemotherapy resulted in a higher percentage of patients with a pathological complete response and longer survival than chemotherapy alone.'
#immunotherapy #Immunology #immunooncology #LungCancer
Thiago Carvalho
boosted
THREAD: Bias and disparity in a causal modeling framework.
1. A few months ago, @vtraag and @LudoWaltman@social.cwts.nlposted a superb paper to the arXiv.
arxiv.org/abs/2207.13665
I've been meaning to write about it for a while and finally found the time.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
