Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'Our current study detects chronic low-level type I interferon (IFN) activation in the cancer cells and the reciprocal astrocytes throughout the brain metastatic process. IFN responses in astrocytes promote brain metastasis by enhancing the recruitment of monocytic myeloid cells in both breast cancer and melanoma models'
#Immunology #immunotherapy #immunooncology

https://www.nature.com/articles/s41467-023-38252-8

🎂 🎉 Today is the 108th birthday of Dichaete, my favourite fly mutation and the first fly Sox gene.

Full or Associate Professorship in Molecular Biology of Plants

University of Zurich, Faculty of Science

The Faculty of Science at the University of Zurich invites applications for the Full or Associate Professorship in Molecular Biology of Plants

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-zurich-faculty-of-s...
https://jobrxiv.org/job/university-of-zurich-faculty-of-science-27778-full-or-associate-professorship-in-molecular-biology-of-plants/?feed_id=48978

Charles Micou & Timothy O'Leary discover that representational drift in #neuralactivity and physiological changes, observed over extended periods, suggests the continuous application of a #learningrule at the #cellular and #populationlevel. This phenomenon serves as a measurable signal to uncover system-level properties of biological #plasticity mechanisms, such as precision and effective #learningrates.

📔 https://doi.org/10.1016/j.conb.2023.102746

#computationalneuroscience #compneuro

Decoding the Fundamental Drivers of Phylodynamic Inference https://doi.org/10.1093/molbev/msad132 #science #evolution #biology #genome #evolgen_paper

Looking for more people on Mastodon who are working in fisheries or oceanography? @Huia_fishocean has a list going!

PhosphoDisco: a toolkit for co-regulated phosphorylation module discovery in phosphoproteomic data | https://www.mcponline.org/article/S1535-9476(23)00107-X/fulltext #proteomics

RT @: Last chance to apply for our #systemsbiology course where you'll learn about:

– #machinelearning
– #multiomics data integration
– functional inference
– network inference and signal propagation
– executable modelling

Applications close 9 July: https://ebi.ac.uk/training/events/systems-biology-large-datasets-biological-insight-1/…

#IDMastodon #Viralimmunity #CovidIsNotOver @medrxivpreprint
Apparently #Omicron sub variants is not mild and the only way to protect your loveones from #COVID19 severity is vaccination . 2 doses of mRNA-1273 vaccine effectiveness is initially strong against symptomatic #SARSCoV2 infection & hospitalization in children aged 6 mth -5 yr.
📌 https://www.medrxiv.org/content/10.1101/2023.06.27.23291933v1.full.pdf
📌 https://www.rcpch.ac.uk/resources/covid-19-vaccination-children-young-people

Hi, since I just moved instance an #introduction is in order.
I am a research software engineer #rse working on #OpenScience for #microscopy (aka #openmicroscopy).

I am also working on #PhysicsOfLife through the development of the #tyssue simulation library.

Super cool overview on the design on of #neuromorphic #computing systems:

Bottom-Up and Top-Down Approaches for the Design of Neuromorphic Processing Systems: Tradeoffs and Synergies Between Natural and Artificial Intelligence

By Charlotte Frenkel, David Bol & @giacomoi

https://ieeexplore.ieee.org/document/10144567

#neuroscience #AI #ML #silicon

Our birds are vanishing. #biodiversity #birds https://nautil.us/a-third-of-north-americas-birds-have-vanished-340007/

Explorer of the immunopeptidome Michal Bassani-Sternberg’s pioneering work on the recognition of cancer antigens is being applied to the design of novel immunotherapies | https://www.ludwigcancerresearch.org/success-story/explorer-of-the-immunopeptidome/ #proteomics

Pictures Considered #60: Vibrio cholerae harpooning DNA

by Christoph
Let me start with an adage: a picture is worth a thousand words. Can this also be valid for video snippets? I think so. Here you see a few seconds of a looping video in loop showing how a cholera bacterium extends a pilus, attaches the tip to DNA in the environment, and then retracts it. Worth a thousand words? Yes, sure, but also deserving 1,000 words...

Read more → https://schaechter.asmblog.org/schaechter/2023/07/pictures-considered-60.html

#microbiology

Onesimus, a Boston enslaved man saved hundreds of people from the horrors of smallpox in 1721. His contributions to science reverberate to this day b/c his knowledge led to what became the 1st vaccine-related study in America. Onesimus’s story illustrates the degree to which reputable men of science de­pended on the testimony & experience of Africans in dealing with a dreaded disease.

1/15

#StillWeRise #Medicine #BlackHistory
#BlackMastodon
#Histodons #History

@blackmastodon@a.gup.pe @BlackMastodon@chirp.social

Issue 12 is complete!

On the cover: skeletal staining of a Xenopus laevis at stage 62. Stage 51 larva was treated with a Cyp26a inhibitor during forelimb regeneration. Notice left forelimb proximo-distal duplication. Image from J.C. Marin-Llera & M.V. Chimal-Montes de Oca

Also in Issue 12:
▪Research Highlights on heart regeneration & hair cell development
▪Interviews with Evgeny Kvon & Hernan Garcia
▪Non-canonical imprinting Spotlight
▪Transcriptional bursting Review
https://journals.biologists.com/dev/issue/150/12

New #PLOSBiology Consensus View provides a guide to the cellular and spatial approaches used in cell type surveys by the BRAIN Initiative Cell Census Network, as well as information on using #BICCN data and resources. #neuroscience
https://plos.io/3CVLbaz

If you are interested in #PhD #AI #machinelearning #retina #ophthalmology #ukbiobank

Check out this fully funded PhD at University of Leicester working with Dr Mervyn Thomas

Institute for Precision Health PhD Studentships | Postgraduate research | University of Leicester
https://le.ac.uk/study/research-degrees/funded-opportunities/iph

Deadline approaching this weekend

Use of non-conventional amino acids for in-cell structural studies

Institut de Biologie Intégrative de la Cellule (I2BC) CEA, CNRS, Univ. Paris Sud, Universite Paris-Saclay

See the full job description on jobRxiv: https://jobrxiv.org/job/institut-de-biologie-integrative-de-la-cel...
https://jobrxiv.org/job/institut-de-biologie-integrative-de-la-cellule-i2bc-cea-cnrs-univ-paris-sud-universite-paris-saclay-27778-use-of-non-conventional-amino-acids-for-in-cell-structural-studies/?feed_id=48950

In the most recent episode we spoke with Claudia Keller Valsecchi from the Institute for Molecular Biology in Mainz about her work on gene dosage alterations in #evolution and #ageing. #womeninstem #epigenetics #podcast

Listen here: https://www.activemotif.com/podcasts#claudia-keller-valsecchi