Thiago Carvalho @cyrilpedia@social.cleverlibre.org

My latest Clinical Pipeline column for Nature Medicine: second generation anti-CD40L drugs for #MultipleSclerosis. A really cool story of deciphering the biology of adverse effects.

#Immunology #autoimmunedisease #drugdevelopment #monoclonalantibodies

https://www.nature.com/articles/d41591-023-00060-4

Sorcery!

"Thousands of genes were simultaneously mapped in intact cells & tissues at molecular resolution, revealing the regulatory principles that specify the location and efficiency of protein production for functionally relevant gene programs across different cell types & tissue regions"

https://www.science.org/doi/10.1126/science.add3067

New paper: Sofia Masuelli, Sebastian Real, Patrick McMillen, Madeleine Oudin, Maria Roque, and I: #bioelectricity, #cancer, and #leftrightasymmetry
https://www.mdpi.com/1422-0067/24/13/11121
"The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left–Right Functional Differences"

Taiwan 🇹🇼 reports its first severe cases of dengue fever in 3 years.

According to CDC physician Lin Yung-ching, four of the 101 domestic cases reported across the country between June 27 and July 3 have been classed as severe.

Quoi?

'We find that at least half of TFs also bind RNA, doing so through a previously unrecognized domain with sequence and functional features analogous to the arginine-rich motif of the HIV transcriptional activator Tat.'

https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00434-3?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

'A qualitative study found that many adults, after receiving a diagnosis of autism, feel a sense of relief3. The diagnosis is a moment of identity-making; genes and biology make phenomena real.'

https://www.nature.com/articles/s41591-023-02403-7

The Reddit AMA as we know it is dead. "The decade-old team of moderators running Reddit AMAs (short for “Ask Me Anything”) are hanging up their boots and will no longer organize the popular Q&As. [They] think Reddit’s poor site management is beyond repair." https://qz.com/reddit-amas-r-iama-protest-api-changes-steve-huffman-1850600843

If you missed it, many! amazing responses in this thread about metaphors in science.

Thanks everyone.

https://neuromatch.social/@NicoleCRust/110639412714199900

#science #metaphor

"If you have expertise in these fields yet don’t combat publicly stated falsehoods, then you’re basically saying that the status quo is acceptable."

- Scott Gilbert

https://thenode.biologists.com/interview-with-scott-gilbert/interview/

"What could possibly go wrong? More than three hundred overprivileged American students travelling the world on a hastily converted troopship, led by a recently sacked university professor determined to prove that travel could be as educational as any university course and keen to make money in the process."

https://literaryreview.co.uk/the-students-who-went-to-sea

'Peering over a conference table in Stockholm, Osswald admits #neuroscience is risky for drugmakers. “It’s a difficult area. But the benefit can be so huge when you have something which is successful,” she says.'

https://www.ft.com/content/28bd7d74-75c9-48d6-8505-717e9f56ca98

'To study regulators of bacterial pathogenicity that are the major drivers of infectious disease outcome, we developed scPAIR-seq, an approach to functionally analyze the effects of bacterial mutants on host immunity at single-cell resolution.'

#Immunology #HostPathogen

https://www.pnas.org/doi/10.1073/pnas.2218812120

Great article by Charlie Warzel at The Atlantic